6KYV

Crystal Structure of RIG-I and hairpin RNA with G-U wobble base pairs

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003676	molecular_function	nucleic acid binding
B	0005524	molecular_function	ATP binding
D	0003676	molecular_function	nucleic acid binding
D	0005524	molecular_function	ATP binding
F	0003676	molecular_function	nucleic acid binding
F	0005524	molecular_function	ATP binding
H	0003676	molecular_function	nucleic acid binding
H	0005524	molecular_function	ATP binding
J	0003676	molecular_function	nucleic acid binding
J	0005524	molecular_function	ATP binding
L	0003676	molecular_function	nucleic acid binding
L	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 1001

Chain	Residue
B	CYS810
B	CYS813
B	CYS864
B	CYS869

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 1001

Chain	Residue
D	CYS810
D	CYS813
D	CYS864
D	CYS869

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN F 1001

Chain	Residue
F	CYS813
F	CYS864
F	CYS869
F	CYS810

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN H 1001

Chain	Residue
H	CYS810
H	CYS813
H	CYS864
H	CYS869

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN J 1001

Chain	Residue
J	CYS810
J	CYS813
J	CYS864
J	CYS869

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN L 1001

Chain	Residue
L	CYS810
L	CYS813
L	CYS864
L	CYS869

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
B	ALA264
D	ALA264
F	ALA264
H	ALA264
J	ALA264
L	ALA264

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01125

Chain	Residue	Details
B	CYS810
B	CYS813
B	CYS864
B	CYS869
D	CYS810
D	CYS813
D	CYS864
D	CYS869
F	CYS810
F	CYS813
F	CYS864
F	CYS869
H	CYS810
H	CYS813
H	CYS864
H	CYS869
J	CYS810
J	CYS813
J	CYS864
J	CYS869
L	CYS810
L	CYS813
L	CYS864
L	CYS869

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: (Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:27866900

Chain	Residue	Details
B	ASN495
B	ASN549
D	ASN495
D	ASN549
F	ASN495
F	ASN549
H	ASN495
H	ASN549
J	ASN495
J	ASN549
L	ASN495
L	ASN549

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:21068236

Chain	Residue	Details
B	THR770
D	THR770
F	THR770
H	THR770
J	THR770
L	THR770

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:21068236

Chain	Residue	Details
B	SER854
B	SER855
D	SER854
D	SER855
F	SER854
F	SER855
H	SER854
H	SER855
J	SER854
J	SER855
L	SER854
L	SER855

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS858
D	LYS858
F	LYS858
H	LYS858
J	LYS858
L	LYS858

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q6Q899

Chain	Residue	Details
H	LYS812
J	LYS812
L	LYS812
B	LYS812
D	LYS812
F	LYS812

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