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6KMR

Crystal structure of human N6amt1-Trm112 in complex with SAM (space group P6122)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006364biological_processrRNA processing
A0008276molecular_functionprotein methyltransferase activity
A0018364biological_processpeptidyl-glutamine methylation
A0030488biological_processtRNA methylation
A0031167biological_processrRNA methylation
A0032991cellular_componentprotein-containing complex
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0046982molecular_functionprotein heterodimerization activity
A0048471cellular_componentperinuclear region of cytoplasm
A0070476biological_processrRNA (guanine-N7)-methylation
A0141106molecular_functiontRNA methyltransferase activator activity
A2000234biological_processpositive regulation of rRNA processing
B0003676molecular_functionnucleic acid binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005829cellular_componentcytosol
B0006325biological_processchromatin organization
B0008168molecular_functionmethyltransferase activity
B0008276molecular_functionprotein methyltransferase activity
B0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
B0009007molecular_functionsite-specific DNA-methyltransferase (adenine-specific) activity
B0009404biological_processtoxin metabolic process
B0018364biological_processpeptidyl-glutamine methylation
B0018872biological_processarsonoacetate metabolic process
B0030307biological_processpositive regulation of cell growth
B0030791molecular_functionarsenite methyltransferase activity
B0032259biological_processmethylation
B0032775biological_processobsolete DNA methylation on adenine
B0032991cellular_componentprotein-containing complex
B0035657cellular_componenteRF1 methyltransferase complex
B0036009molecular_functionprotein-glutamine N-methyltransferase activity
B0042054molecular_functionhistone methyltransferase activity
B0045814biological_processnegative regulation of gene expression, epigenetic
B0045815biological_processtranscription initiation-coupled chromatin remodeling
B0140984molecular_functionhistone H4K12 methyltransferase activity
B1904047molecular_functionS-adenosyl-L-methionine binding
Functional Information from PDB Data
site_idAC1
Number of Residues1
Detailsbinding site for residue EDO A 201
ChainResidue
APRO101

site_idAC2
Number of Residues20
Detailsbinding site for residue SAM B 301
ChainResidue
BILE78
BASP103
BLEU104
BASN122
BPRO124
BALA140
BALA141
BARG154
BHOH422
BHOH437
BTYR23
BHOH442
BHOH449
BTHR29
BGLU51
BGLY53
BSER54
BGLY55
BVAL59
BASP77

Functional Information from PROSITE/UniProt
site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. LVFNPPY
ChainResidueDetails
BLEU119-TYR125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:31636962, ECO:0000269|PubMed:32969463, ECO:0007744|PDB:6K0X, ECO:0007744|PDB:6KMR, ECO:0007744|PDB:6KMS
ChainResidueDetails
BTHR29
BGLU51
BASP77
BASP103
BLEU104
BASN122

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:31636962, ECO:0007744|PDB:6KMR, ECO:0007744|PDB:6KMS
ChainResidueDetails
BGLY53

226707

PDB entries from 2024-10-30

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