6KDN
HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:dGTP ternary complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 601 |
| Chain | Residue |
| A | ASP110 |
| A | VAL111 |
| A | ASP185 |
| A | DGT602 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue DGT A 602 |
| Chain | Residue |
| A | ASP113 |
| A | ALA114 |
| A | PHE115 |
| A | MET151 |
| A | GLY152 |
| A | MET184 |
| A | ASP185 |
| A | LYS220 |
| A | MG601 |
| E | DC0 |
| E | DG1 |
| E | DC33 |
| E | HOH104 |
| A | LYS65 |
| A | ARG72 |
| A | ASP110 |
| A | VAL111 |
| A | GLY112 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | TRP266 |
| A | HOH705 |
| A | HOH708 |
| E | DG30 |
| E | HOH124 |
| E | HOH125 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| A | GLN407 |
| A | ALA408 |
| A | THR409 |
| B | ILE393 |
| B | GLN394 |
| B | THR397 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| A | LEU92 |
| A | VAL381 |
| B | GLN23 |
| B | TRP24 |
| B | PRO25 |
| B | ASN137 |
| B | HOH604 |
| B | HOH611 |
| B | HOH619 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 601 |
| Chain | Residue |
| C | ASP110 |
| C | VAL111 |
| C | ASP185 |
| C | DGT602 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | binding site for residue DGT C 602 |
| Chain | Residue |
| C | LYS65 |
| C | ARG72 |
| C | ASP110 |
| C | VAL111 |
| C | GLY112 |
| C | ASP113 |
| C | ALA114 |
| C | PHE115 |
| C | MET151 |
| C | GLY152 |
| C | MET184 |
| C | ASP185 |
| C | LYS220 |
| C | MG601 |
| C | HOH739 |
| C | HOH791 |
| C | HOH793 |
| F | DC0 |
| F | DG1 |
| F | DC33 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| C | LEU92 |
| C | VAL381 |
| D | GLN23 |
| D | TRP24 |
| D | PRO25 |
| D | PRO133 |
| D | ASN137 |
| D | HOH601 |
| D | HOH606 |
| D | HOH613 |
| D | HOH655 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| C | GLN407 |
| C | ALA408 |
| C | THR409 |
| C | HOH740 |
| D | ILE393 |
| D | GLN394 |
| D | THR397 |
| D | HOH628 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for Di-nucleotide DG F 1 and OMC F 2 |
| Chain | Residue |
| F | HOH103 |
| F | HOH129 |
| C | ARG78 |
| C | ASN81 |
| C | GLU89 |
| C | GLY152 |
| C | LYS154 |
| C | PRO157 |
| C | GLN161 |
| C | MET184 |
| C | DGT602 |
| F | DC0 |
| F | DC3 |
| F | DG32 |
| F | DC33 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for Di-nucleotide OMC F 2 and DC F 3 |
| Chain | Residue |
| C | GLU89 |
| C | GLN91 |
| C | ILE94 |
| C | PRO157 |
| C | GLN161 |
| C | TYR183 |
| F | DG1 |
| F | OMC4 |
| F | DG31 |
| F | DG32 |
| F | HOH103 |
| F | HOH125 |
| site_id | AD3 |
| Number of Residues | 17 |
| Details | binding site for Di-nucleotide DC F 3 and OMC F 4 |
| Chain | Residue |
| C | GLU89 |
| C | GLN91 |
| C | LEU92 |
| C | ILE94 |
| C | TYR183 |
| C | HOH783 |
| D | LYS22 |
| F | OMC2 |
| F | DC5 |
| F | DG30 |
| F | DG31 |
| F | DG32 |
| F | HOH111 |
| F | HOH114 |
| F | HOH122 |
| F | HOH125 |
| F | HOH131 |
| site_id | AD4 |
| Number of Residues | 14 |
| Details | binding site for Di-nucleotide OMC F 4 and DC F 5 |
| Chain | Residue |
| C | LEU92 |
| C | ILE94 |
| C | HOH783 |
| D | LYS22 |
| F | DC3 |
| F | DC6 |
| F | DG29 |
| F | DG30 |
| F | DG31 |
| F | HOH111 |
| F | HOH114 |
| F | HOH116 |
| F | HOH122 |
| F | HOH131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 380 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"RT 'primer grip'","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | Motif: {"description":"Tryptophan repeat motif","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Site: {"description":"Essential for RT p66/p51 heterodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by viral protease; partial","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
