6KC4

Crystal structure of human Fer SH2 domain bound to a phosphopeptide (DEpYENVD)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005154	molecular_function	epidermal growth factor receptor binding
A	0008283	biological_process	cell population proliferation
A	0030335	biological_process	positive regulation of cell migration
A	0031532	biological_process	actin cytoskeleton reorganization
A	0042058	biological_process	regulation of epidermal growth factor receptor signaling pathway
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005154	molecular_function	epidermal growth factor receptor binding
C	0008283	biological_process	cell population proliferation
C	0030335	biological_process	positive regulation of cell migration
C	0031532	biological_process	actin cytoskeleton reorganization
C	0042058	biological_process	regulation of epidermal growth factor receptor signaling pathway
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0005154	molecular_function	epidermal growth factor receptor binding
E	0008283	biological_process	cell population proliferation
E	0030335	biological_process	positive regulation of cell migration
E	0031532	biological_process	actin cytoskeleton reorganization
E	0042058	biological_process	regulation of epidermal growth factor receptor signaling pathway
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0004713	molecular_function	protein tyrosine kinase activity
G	0005154	molecular_function	epidermal growth factor receptor binding
G	0008283	biological_process	cell population proliferation
G	0030335	biological_process	positive regulation of cell migration
G	0031532	biological_process	actin cytoskeleton reorganization
G	0042058	biological_process	regulation of epidermal growth factor receptor signaling pathway
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
I	0004713	molecular_function	protein tyrosine kinase activity
I	0005154	molecular_function	epidermal growth factor receptor binding
I	0008283	biological_process	cell population proliferation
I	0030335	biological_process	positive regulation of cell migration
I	0031532	biological_process	actin cytoskeleton reorganization
I	0042058	biological_process	regulation of epidermal growth factor receptor signaling pathway
I	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
K	0004713	molecular_function	protein tyrosine kinase activity
K	0005154	molecular_function	epidermal growth factor receptor binding
K	0008283	biological_process	cell population proliferation
K	0030335	biological_process	positive regulation of cell migration
K	0031532	biological_process	actin cytoskeleton reorganization
K	0042058	biological_process	regulation of epidermal growth factor receptor signaling pathway
K	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	540
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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