6K0Y
Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | PHE172 |
| B | SER176 |
| B | HOH401 |
| A | PRO173 |
| A | VAL175 |
| A | SER183 |
| A | LEU184 |
| A | SER185 |
| A | HOH602 |
| A | HOH724 |
| B | SER162 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | VAL2 |
| A | HIS27 |
| A | TYR33 |
| A | ARG98 |
| A | HOH611 |
| A | HOH686 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 301 |
| Chain | Residue |
| B | LEU54 |
| B | SER60 |
| B | PHE62 |
| B | SER63 |
| B | HOH455 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 201 |
| Chain | Residue |
| C | THR59 |
| C | SER60 |
| C | GLU61 |
| C | PHE63 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH |
| Chain | Residue | Details |
| A | TYR200-HIS206 | |
| B | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 110 |
| Details | Domain: {"description":"Ig-like V-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Region: {"description":"Interaction with CD274/PDCD1L1","evidences":[{"source":"PubMed","id":"26602187","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 25 |
| Details | Region: {"description":"Pembrolizumab binding","evidences":[{"source":"PubMed","id":"27325296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27734966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5B8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JXE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WT9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
