6JTG
Structural insights into G domain dimerization and pathogenic mutations of OPA1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GDP A 401 |
| Chain | Residue |
| A | SER36 |
| A | LYS206 |
| A | ASP208 |
| A | LEU209 |
| A | VAL240 |
| A | THR241 |
| A | GLY242 |
| A | LYS243 |
| A | GLY244 |
| A | MG402 |
| A | BEF403 |
| A | ALA37 |
| A | K404 |
| A | HOH506 |
| A | HOH519 |
| A | HOH565 |
| A | GLY38 |
| A | LYS39 |
| A | THR40 |
| A | SER41 |
| A | ARG54 |
| A | GLY55 |
| A | SER56 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | THR40 |
| A | THR61 |
| A | ASP136 |
| A | GDP401 |
| A | BEF403 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue BEF A 403 |
| Chain | Residue |
| A | GLN35 |
| A | SER36 |
| A | LYS39 |
| A | MET60 |
| A | THR61 |
| A | GLY139 |
| A | GDP401 |
| A | MG402 |
| A | K404 |
| A | HOH517 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue K A 404 |
| Chain | Residue |
| A | SER36 |
| A | GLY55 |
| A | GLU58 |
| A | GDP401 |
| A | BEF403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:32379273, ECO:0007744|PDB:6JTG |
| Chain | Residue | Details |
| A | VAL32 | |
| A | PHE237 | |
| A | ASP34 | |
| A | GLN35 | |
| A | SER36 | |
| A | ILE51 | |
| A | GLY57 | |
| A | MET132 | |
| A | PHE202 | |
| A | LEU204 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:32379273, ECO:0000305|PubMed:37612506, ECO:0007744|PDB:6JTG, ECO:0007744|PDB:8EEW |
| Chain | Residue | Details |
| A | ALA37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:37612506, ECO:0007744|PDB:8EEW |
| Chain | Residue | Details |
| A | VAL240 | |
| A | THR241 |
