6JTG
Structural insights into G domain dimerization and pathogenic mutations of OPA1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GDP A 401 |
| Chain | Residue |
| A | SER36 |
| A | LYS206 |
| A | ASP208 |
| A | LEU209 |
| A | VAL240 |
| A | THR241 |
| A | GLY242 |
| A | LYS243 |
| A | GLY244 |
| A | MG402 |
| A | BEF403 |
| A | ALA37 |
| A | K404 |
| A | HOH506 |
| A | HOH519 |
| A | HOH565 |
| A | GLY38 |
| A | LYS39 |
| A | THR40 |
| A | SER41 |
| A | ARG54 |
| A | GLY55 |
| A | SER56 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | THR40 |
| A | THR61 |
| A | ASP136 |
| A | GDP401 |
| A | BEF403 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue BEF A 403 |
| Chain | Residue |
| A | GLN35 |
| A | SER36 |
| A | LYS39 |
| A | MET60 |
| A | THR61 |
| A | GLY139 |
| A | GDP401 |
| A | MG402 |
| A | K404 |
| A | HOH517 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue K A 404 |
| Chain | Residue |
| A | SER36 |
| A | GLY55 |
| A | GLU58 |
| A | GDP401 |
| A | BEF403 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 276 |
| Details | Domain: {"description":"Dynamin-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32379273","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6JTG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32379273","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6JTG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EEW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37612506","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EEW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
