Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JTA

Crystal Structure of D464A L465A mutant of FGAM Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue ADP A 1301

Chain	Residue
A	VAL333
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1338
A	MG1339
A	MG1340
A	HOH1492
A	PHE335
A	HOH1551
A	HOH1566
A	HOH1635
A	HOH1674
A	HOH1685
A	HOH1714
A	HOH1778
A	HOH1944
A	HOH1981
A	HOH2026
A	THR386
A	HOH2100
A	HOH2163
A	HOH2225
A	GLY387
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	GLN668

site_id	AC2
Number of Residues	17
Details	binding site for residue GLN A 1302

Chain	Residue
A	GLY1092
A	GLY1093
A	PHE1094
A	ASP1098
A	CYS1135
A	ASN1136
A	GLN1139
A	PHE1165
A	SER1195
A	HIS1196
A	GLY1197
A	GLU1198
A	HIS1260
A	ARG1263
A	HOH1417
A	HOH2091
A	HOH2115

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 1303

Chain	Residue
A	HIS902
A	GLY961
A	ARG978
A	ASP1012
A	HOH1827
A	HOH1898

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 1304

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH1553
A	HOH1799

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 1305

Chain	Residue
A	VAL616
A	GLN617
A	PRO747
A	GLY748
A	ASP750
A	HOH1908
A	HOH1965
A	HOH2243

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL A 1306

Chain	Residue
A	ALA911
A	HIS953
A	TYR954
A	HOH1418
A	HOH1439
A	HOH1559
A	HOH2078

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL A 1307

Chain	Residue
A	ILE1148
A	PRO1149
A	GLY1150
A	SER1151
A	GLU1152
A	EDO1320

site_id	AC8
Number of Residues	8
Details	binding site for residue GOL A 1308

Chain	Residue
A	ASP250
A	TYR251
A	GLU264
A	GLU1007
A	HOH1427
A	HOH1468
A	HOH1496
A	HOH1988

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL A 1309

Chain	Residue
A	PHE238
A	TYR256
A	VAL774
A	GLY775
A	EDO1325
A	HOH1713
A	HOH2244

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL A 1310

Chain	Residue
A	ASP915
A	HOH1583
A	HOH1621
A	HOH1687
A	HOH2271
A	GLY913
A	ASP914

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL A 1311

Chain	Residue
A	GLU264
A	ALA267
A	PRO286
A	GLN1000
A	GLN1004
A	GLU1007
A	HOH1562
A	HOH1751
A	HOH2325

site_id	AD3
Number of Residues	8
Details	binding site for residue EDO A 1312

Chain	Residue
A	GLY441
A	PRO442
A	MET444
A	SER547
A	GLN548
A	ARG550
A	HOH1788
A	HOH1868

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO A 1313

Chain	Residue
A	PRO1274
A	GLU1275
A	HOH2295

site_id	AD5
Number of Residues	8
Details	binding site for residue GOL A 1314

Chain	Residue
A	SER689
A	TYR690
A	TYR691
A	VAL1229
A	THR1230
A	GLU1231
A	HOH1478
A	HOH1618

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO A 1315

Chain	Residue
A	THR581
A	GLU582
A	GLU583

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO A 1316

Chain	Residue
A	ARG936
A	TYR954
A	HOH1439
A	HOH1960
A	HOH2098

site_id	AD8
Number of Residues	3
Details	binding site for residue EDO A 1317

Chain	Residue
A	HIS813
A	ARG877
A	HOH2470

site_id	AD9
Number of Residues	5
Details	binding site for residue EDO A 1318

Chain	Residue
A	PHE245
A	GLU246
A	PRO249
A	HOH1798
A	HOH1875

site_id	AE1
Number of Residues	8
Details	binding site for residue EDO A 1319

Chain	Residue
A	LYS833
A	GLN862
A	GLY947
A	LEU948
A	ALA949
A	ASP950
A	CYS951
A	HOH1544

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO A 1320

Chain	Residue
A	HIS1125
A	PRO1149
A	GOL1307

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO A 1321

Chain	Residue
A	ARG15
A	GLU368
A	ARG996
A	HOH1477

site_id	AE4
Number of Residues	4
Details	binding site for residue EDO A 1322

Chain	Residue
A	GLN1183
A	ARG1285
A	HOH2016
A	HOH2111

site_id	AE5
Number of Residues	7
Details	binding site for residue EDO A 1323

Chain	Residue
A	HIS216
A	HIS219
A	LYS776
A	EDO1325
A	SO41346
A	HOH1505
A	HOH1652

site_id	AE6
Number of Residues	8
Details	binding site for residue EDO A 1324

Chain	Residue
A	LYS732
A	PRO766
A	GLN767
A	GLY769
A	HOH1608
A	HOH1642
A	HOH1679
A	HOH2425

site_id	AE7
Number of Residues	11
Details	binding site for residue EDO A 1325

Chain	Residue
A	ASN259
A	LYS292
A	GLU294
A	ASP318
A	GLY775
A	LYS776
A	GOL1309
A	EDO1323
A	SO41346
A	HOH1652
A	HOH1743

site_id	AE8
Number of Residues	5
Details	binding site for residue EDO A 1326

Chain	Residue
A	ILE172
A	ASN175
A	LEU176
A	ILE187
A	HOH1426

site_id	AE9
Number of Residues	5
Details	binding site for residue EDO A 1327

Chain	Residue
A	ASP529
A	VAL576
A	ILE577
A	GLY578
A	ASP579

site_id	AF1
Number of Residues	7
Details	binding site for residue EDO A 1328

Chain	Residue
A	ARG963
A	SER975
A	GLU976
A	SER977
A	HOH1554
A	HOH2116
A	HOH2215

site_id	AF2
Number of Residues	1
Details	binding site for residue EDO A 1329

Chain	Residue
A	HIS835

site_id	AF3
Number of Residues	5
Details	binding site for residue EDO A 1330

Chain	Residue
A	MET456
A	ALA457
A	LYS782
A	ARG784
A	HOH1754

site_id	AF4
Number of Residues	9
Details	binding site for residue GOL A 1331

Chain	Residue
A	GLU648
A	THR650
A	TRP673
A	GLN674
A	GLU1005
A	LYS1009
A	HOH1824
A	HOH1896
A	HOH2281

site_id	AF5
Number of Residues	7
Details	binding site for residue EDO A 1332

Chain	Residue
A	ALA744
A	HIS746
A	LYS782
A	ARG784
A	GLU793
A	HOH1915
A	HOH2253

site_id	AF6
Number of Residues	8
Details	binding site for residue EDO A 1333

Chain	Residue
A	HIS296
A	GLY504
A	GLU546
A	GLN548
A	SO41346
A	HOH2033
A	HOH2130
A	HOH2237

site_id	AF7
Number of Residues	3
Details	binding site for residue EDO A 1334

Chain	Residue
A	GLU350
A	GLU351
A	ARG848

site_id	AF8
Number of Residues	5
Details	binding site for residue GOL A 1335

Chain	Residue
A	ARG713
A	ASP755
A	GLU763
A	HOH1405
A	HOH1963

site_id	AF9
Number of Residues	4
Details	binding site for residue EDO A 1336

Chain	Residue
A	HIS132
A	ARG134
A	GLU137
A	HOH2000

site_id	AG1
Number of Residues	5
Details	binding site for residue EDO A 1337

Chain	Residue
A	GLY1037
A	ALA1038
A	ARG1039
A	HOH1467
A	HOH1508

site_id	AG2
Number of Residues	6
Details	binding site for residue MG A 1338

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1301
A	HOH1685
A	HOH2026

site_id	AG3
Number of Residues	5
Details	binding site for residue MG A 1339

Chain	Residue
A	ADP1301
A	HOH1436
A	HOH1566
A	HOH1778
A	HOH1981

site_id	AG4
Number of Residues	6
Details	binding site for residue MG A 1340

Chain	Residue
A	GLU718
A	ADP1301
A	HOH1551
A	HOH1635
A	HOH1677
A	HOH1944

site_id	AG5
Number of Residues	11
Details	binding site for residue SO4 A 1341

Chain	Residue
A	HIS216
A	THR295
A	HIS296
A	ASN297
A	HIS298
A	SER454
A	SER778
A	HOH1437
A	HOH1438
A	HOH1680
A	HOH2349

site_id	AG6
Number of Residues	9
Details	binding site for residue SO4 A 1342

Chain	Residue
A	HIS1086
A	ARG1126
A	GLN1128
A	THR1129
A	HOH1487
A	HOH1501
A	HOH1647
A	HOH2291
A	HOH2306

site_id	AG7
Number of Residues	8
Details	binding site for residue SO4 A 1343

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1499
A	HOH1747
A	HOH1842
A	HOH1947
A	HOH2073

site_id	AG8
Number of Residues	7
Details	binding site for residue SO4 A 1344

Chain	Residue
A	ARG812
A	LYS1228
A	VAL1229
A	HOH1478
A	HOH1694
A	HOH1727
A	HOH1866

site_id	AG9
Number of Residues	3
Details	binding site for residue SO4 A 1345

Chain	Residue
A	ASN1113
A	ARG1115
A	HOH2189

site_id	AH1
Number of Residues	13
Details	binding site for residue SO4 A 1346

Chain	Residue
A	HIS216
A	GLU294
A	GLY504
A	ALA505
A	LYS776
A	EDO1323
A	EDO1325
A	EDO1333
A	HOH1408
A	HOH1603
A	HOH1652
A	HOH1849
A	HOH2124

site_id	AH2
Number of Residues	6
Details	binding site for residue SO4 A 1347

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	HOH1453
A	HOH1467
A	HOH1522

site_id	AH3
Number of Residues	8
Details	binding site for residue SO4 A 1348

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1581
A	HOH1591
A	HOH1907

site_id	AH4
Number of Residues	6
Details	binding site for residue SO4 A 1349

Chain	Residue
A	THR632
A	ILE633
A	HOH1430
A	HOH1902
A	HOH2027
A	HOH2038

site_id	AH5
Number of Residues	6
Details	binding site for residue SO4 A 1350

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	HIS1161
A	HOH1811

site_id	AH6
Number of Residues	7
Details	binding site for residue SO4 A 1351

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	GLN460
A	HOH1414
A	HOH1575
A	HOH2167

site_id	AH7
Number of Residues	4
Details	binding site for residue SO4 A 1352

Chain	Residue
A	LYS833
A	HIS835
A	HOH1632
A	HOH1658

site_id	AH8
Number of Residues	3
Details	binding site for residue SO4 A 1353

Chain	Residue
A	HIS152
A	HIS153
A	GLN154

site_id	AH9
Number of Residues	3
Details	binding site for residue SO4 A 1354

Chain	Residue
A	ASN1251
A	ARG1253
A	HOH2201

site_id	AI1
Number of Residues	5
Details	binding site for residue SO4 A 1355

Chain	Residue
A	ARG218
A	LYS220
A	ASN223
A	LYS611
A	HOH1888

site_id	AI2
Number of Residues	2
Details	binding site for residue SO4 A 1356

Chain	Residue
A	HIS68
A	THR69

site_id	AI3
Number of Residues	5
Details	binding site for residue SO4 A 1357

Chain	Residue
A	GLN54
A	PHE1112
A	HIS1114
A	HOH1555
A	HOH1684

site_id	AI4
Number of Residues	3
Details	binding site for residue SO4 A 1358

Chain	Residue
A	HIS0
A	ILE151
A	HIS152

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	CYS1135

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	HIS1260
A	GLU1262

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLY307

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	THR386
A	ALA678
A	SER886

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419, ECO:0000269\|PubMed:15301531, ECO:0000269\|PubMed:22683785, ECO:0000269\|PubMed:24223728

Chain	Residue	Details
A	ASP679
A	GLU718
A	ASN722
A	ASP884

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)