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6JIG

Crystal structure of GMP reductase C318A from Trypanosoma brucei in complex with guanosine 5'-monophosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0003920molecular_functionGMP reductase activity
A0003938molecular_functionIMP dehydrogenase activity
A0005525molecular_functionGTP binding
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006144biological_processpurine nucleobase metabolic process
A0006164biological_processpurine nucleotide biosynthetic process
A0006177biological_processGMP biosynthetic process
A0006183biological_processGTP biosynthetic process
A0009152biological_processpurine ribonucleotide biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0020015cellular_componentglycosome
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues26
Detailsbinding site for residue 5GP A 601
ChainResidue
ASER52
AGLY353
AMET372
AGLY374
AASN375
AGLY400
AMET401
AALA402
AGLU428
AGLY429
AHOH718
AASN290
AHOH727
AHOH743
AHOH753
AHOH760
AHOH761
AHOH774
AHOH781
AGLY315
ASER316
AILE317
AALA318
ATHR320
AASP351
AGLY352

site_idAC2
Number of Residues17
Detailsbinding site for residue 5GP A 602
ChainResidue
AARG93
AALA94
AGLN95
ASER96
AILE99
APRO102
AARG103
AARG123
AVAL127
AGLY128
ACYS129
ALEU206
ASER210
AASP211
AHOH701
AHOH728
AHOH748

site_idAC3
Number of Residues6
Detailsbinding site for residue K A 603
ChainResidue
AGLY313
AGLY315
AALA318
AGLU482
ASER483
AGLY484

249697

PDB entries from 2026-02-25

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