6JIG
Crystal structure of GMP reductase C318A from Trypanosoma brucei in complex with guanosine 5'-monophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003920 | molecular_function | GMP reductase activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0020015 | cellular_component | glycosome |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue 5GP A 601 |
| Chain | Residue |
| A | SER52 |
| A | GLY353 |
| A | MET372 |
| A | GLY374 |
| A | ASN375 |
| A | GLY400 |
| A | MET401 |
| A | ALA402 |
| A | GLU428 |
| A | GLY429 |
| A | HOH718 |
| A | ASN290 |
| A | HOH727 |
| A | HOH743 |
| A | HOH753 |
| A | HOH760 |
| A | HOH761 |
| A | HOH774 |
| A | HOH781 |
| A | GLY315 |
| A | SER316 |
| A | ILE317 |
| A | ALA318 |
| A | THR320 |
| A | ASP351 |
| A | GLY352 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue 5GP A 602 |
| Chain | Residue |
| A | ARG93 |
| A | ALA94 |
| A | GLN95 |
| A | SER96 |
| A | ILE99 |
| A | PRO102 |
| A | ARG103 |
| A | ARG123 |
| A | VAL127 |
| A | GLY128 |
| A | CYS129 |
| A | LEU206 |
| A | SER210 |
| A | ASP211 |
| A | HOH701 |
| A | HOH728 |
| A | HOH748 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue K A 603 |
| Chain | Residue |
| A | GLY313 |
| A | GLY315 |
| A | ALA318 |
| A | GLU482 |
| A | SER483 |
| A | GLY484 |






