6J4Q

Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0045765	biological_process	regulation of angiogenesis
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0006508	biological_process	proteolysis
B	0008017	molecular_function	microtubule binding
B	0009306	biological_process	protein secretion
B	0010596	biological_process	negative regulation of endothelial cell migration
B	0016504	molecular_function	peptidase activator activity
B	0031397	biological_process	negative regulation of protein ubiquitination
B	0045177	cellular_component	apical part of cell
B	0061564	biological_process	axon development
B	1905048	biological_process	regulation of metallopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0045765	biological_process	regulation of angiogenesis
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0006508	biological_process	proteolysis
D	0008017	molecular_function	microtubule binding
D	0009306	biological_process	protein secretion
D	0010596	biological_process	negative regulation of endothelial cell migration
D	0016504	molecular_function	peptidase activator activity
D	0031397	biological_process	negative regulation of protein ubiquitination
D	0045177	cellular_component	apical part of cell
D	0061564	biological_process	axon development
D	1905048	biological_process	regulation of metallopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0045765	biological_process	regulation of angiogenesis
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0006508	biological_process	proteolysis
G	0008017	molecular_function	microtubule binding
G	0009306	biological_process	protein secretion
G	0010596	biological_process	negative regulation of endothelial cell migration
G	0016504	molecular_function	peptidase activator activity
G	0031397	biological_process	negative regulation of protein ubiquitination
G	0045177	cellular_component	apical part of cell
G	0061564	biological_process	axon development
G	1905048	biological_process	regulation of metallopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0045765	biological_process	regulation of angiogenesis
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0006508	biological_process	proteolysis
K	0008017	molecular_function	microtubule binding
K	0009306	biological_process	protein secretion
K	0010596	biological_process	negative regulation of endothelial cell migration
K	0016504	molecular_function	peptidase activator activity
K	0031397	biological_process	negative regulation of protein ubiquitination
K	0045177	cellular_component	apical part of cell
K	0061564	biological_process	axon development
K	1905048	biological_process	regulation of metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue TQ8 A 301

Chain	Residue
A	TYR123
A	CYS158
A	PHE191
A	HIS192
A	HIS193
A	SER210
A	ARG211
A	LEU215

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 302

Chain	Residue
A	ALA213
A	ASP217
F	PRO261
A	LYS119

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 303

Chain	Residue
A	LYS135
A	HIS192
A	HIS193

---

site_id	AC4
Number of Residues	7
Details	binding site for residue TQ8 B 101

Chain	Residue
A	GLU214
A	TYR239
B	CYS58
F	ARG137
F	PRO138
F	GLY141
F	GLU144

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL C 302

Chain	Residue
C	LYS135
C	HIS192
C	HIS193
C	VAL194

---

site_id	AC6
Number of Residues	1
Details	binding site for residue GOL F 302

Chain	Residue
F	LYS135

---

site_id	AC7
Number of Residues	2
Details	binding site for residue GOL J 302

Chain	Residue
J	LYS135
J	VAL194

---

site_id	AC8
Number of Residues	14
Details	binding site for Di-peptide TQ8 C 301 and CYS C 158

Chain	Residue
C	TYR123
C	LYS157
C	LEU159
C	GLU160
C	ALA161
C	VAL162
C	PHE191
C	HIS192
C	HIS193
C	VAL194
C	MET209
C	SER210
C	ARG211
C	LEU215

---

site_id	AC9
Number of Residues	14
Details	binding site for Di-peptide TQ8 F 301 and CYS F 158

Chain	Residue
F	TYR123
F	LYS157
F	LEU159
F	GLU160
F	ALA161
F	VAL162
F	PHE191
F	HIS192
F	HIS193
F	VAL194
F	MET209
F	SER210
F	ARG211
F	HIS241

---

site_id	AD1
Number of Residues	11
Details	binding site for Di-peptide TQ8 G 101 and CYS G 58

Chain	Residue
A	ARG134
A	ARG137
A	PRO138
A	GLY141
A	GLU144
F	GLU214
G	PHE54
G	ASP55
G	GLU56
G	PHE57
G	HOH203

---

site_id	AD2
Number of Residues	16
Details	binding site for Di-peptide TQ8 J 301 and CYS J 158

Chain	Residue
J	TYR123
J	LYS157
J	LEU159
J	GLU160
J	ALA161
J	VAL162
J	PHE191
J	HIS192
J	HIS193
J	VAL194
J	MET209
J	SER210
J	ARG211
J	LEU215
J	HIS241
J	HOH405

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"29146869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PubMed","id":"26794318","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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