6IYB

Structure of human ORP1 ANK - Rab7 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000166	molecular_function	nucleotide binding
A	0000421	cellular_component	autophagosome membrane
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005770	cellular_component	late endosome
A	0005794	cellular_component	Golgi apparatus
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006622	biological_process	protein targeting to lysosome
A	0006629	biological_process	lipid metabolic process
A	0006897	biological_process	endocytosis
A	0006914	biological_process	autophagy
A	0007174	biological_process	epidermal growth factor catabolic process
A	0008333	biological_process	endosome to lysosome transport
A	0009617	biological_process	response to bacterium
A	0010008	cellular_component	endosome membrane
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019076	biological_process	viral release from host cell
A	0022615	biological_process	protein to membrane docking
A	0030667	cellular_component	secretory granule membrane
A	0030670	cellular_component	phagocytic vesicle membrane
A	0030672	cellular_component	synaptic vesicle membrane
A	0030904	cellular_component	retromer complex
A	0031267	molecular_function	small GTPase binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031902	cellular_component	late endosome membrane
A	0031966	cellular_component	mitochondrial membrane
A	0033162	cellular_component	melanosome membrane
A	0034045	cellular_component	phagophore assembly site membrane
A	0036466	biological_process	synaptic vesicle recycling via endosome
A	0042147	biological_process	retrograde transport, endosome to Golgi
A	0045022	biological_process	early endosome to late endosome transport
A	0045335	cellular_component	phagocytic vesicle
A	0045453	biological_process	bone resorption
A	0045732	biological_process	positive regulation of protein catabolic process
A	0048524	biological_process	positive regulation of viral process
A	0051650	biological_process	establishment of vesicle localization
A	0061462	biological_process	protein localization to lysosome
A	0061724	biological_process	lipophagy
A	0070062	cellular_component	extracellular exosome
A	0090382	biological_process	phagosome maturation
A	0090383	biological_process	phagosome acidification
A	0090385	biological_process	phagosome-lysosome fusion
A	0097208	cellular_component	alveolar lamellar body
A	0098588	cellular_component	bounding membrane of organelle
A	0098830	cellular_component	presynaptic endosome
A	0098943	biological_process	neurotransmitter receptor transport, postsynaptic endosome to lysosome
A	0098978	cellular_component	glutamatergic synapse
A	0099003	biological_process	vesicle-mediated transport in synapse
A	0099638	biological_process	endosome to plasma membrane protein transport
A	1903542	biological_process	negative regulation of exosomal secretion
A	1903543	biological_process	positive regulation of exosomal secretion
A	1905366	biological_process	negative regulation of intralumenal vesicle formation
A	1905394	molecular_function	retromer complex binding
C	0000045	biological_process	autophagosome assembly
C	0000166	molecular_function	nucleotide binding
C	0000421	cellular_component	autophagosome membrane
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005768	cellular_component	endosome
C	0005770	cellular_component	late endosome
C	0005794	cellular_component	Golgi apparatus
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006622	biological_process	protein targeting to lysosome
C	0006629	biological_process	lipid metabolic process
C	0006897	biological_process	endocytosis
C	0006914	biological_process	autophagy
C	0007174	biological_process	epidermal growth factor catabolic process
C	0008333	biological_process	endosome to lysosome transport
C	0009617	biological_process	response to bacterium
C	0010008	cellular_component	endosome membrane
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0019003	molecular_function	GDP binding
C	0019076	biological_process	viral release from host cell
C	0022615	biological_process	protein to membrane docking
C	0030667	cellular_component	secretory granule membrane
C	0030670	cellular_component	phagocytic vesicle membrane
C	0030672	cellular_component	synaptic vesicle membrane
C	0030904	cellular_component	retromer complex
C	0031267	molecular_function	small GTPase binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031902	cellular_component	late endosome membrane
C	0031966	cellular_component	mitochondrial membrane
C	0033162	cellular_component	melanosome membrane
C	0034045	cellular_component	phagophore assembly site membrane
C	0036466	biological_process	synaptic vesicle recycling via endosome
C	0042147	biological_process	retrograde transport, endosome to Golgi
C	0045022	biological_process	early endosome to late endosome transport
C	0045335	cellular_component	phagocytic vesicle
C	0045453	biological_process	bone resorption
C	0045732	biological_process	positive regulation of protein catabolic process
C	0048524	biological_process	positive regulation of viral process
C	0051650	biological_process	establishment of vesicle localization
C	0061462	biological_process	protein localization to lysosome
C	0061724	biological_process	lipophagy
C	0070062	cellular_component	extracellular exosome
C	0090382	biological_process	phagosome maturation
C	0090383	biological_process	phagosome acidification
C	0090385	biological_process	phagosome-lysosome fusion
C	0097208	cellular_component	alveolar lamellar body
C	0098588	cellular_component	bounding membrane of organelle
C	0098830	cellular_component	presynaptic endosome
C	0098943	biological_process	neurotransmitter receptor transport, postsynaptic endosome to lysosome
C	0098978	cellular_component	glutamatergic synapse
C	0099003	biological_process	vesicle-mediated transport in synapse
C	0099638	biological_process	endosome to plasma membrane protein transport
C	1903542	biological_process	negative regulation of exosomal secretion
C	1903543	biological_process	positive regulation of exosomal secretion
C	1905366	biological_process	negative regulation of intralumenal vesicle formation
C	1905394	molecular_function	retromer complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 1301

Chain	Residue
A	THR22
A	THR40
A	GTP1302
A	HOH1425
A	HOH1431

---

site_id	AC2
Number of Residues	25
Details	binding site for residue GTP A 1302

Chain	Residue
A	LYS21
A	THR22
A	SER23
A	PHE33
A	SER34
A	ASN35
A	TYR37
A	THR40
A	GLY66
A	ASN125
A	LYS126
A	ASP128
A	LEU129
A	SER155
A	ALA156
A	LYS157
A	MG1301
A	HOH1413
A	HOH1425
A	HOH1431
A	HOH1458
A	SER17
A	GLY18
A	VAL19
A	GLY20

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG C 1301

Chain	Residue
C	THR22
C	THR40
C	GTP1302
C	HOH1403
C	HOH1407

---

site_id	AC4
Number of Residues	24
Details	binding site for residue GTP C 1302

Chain	Residue
C	SER17
C	GLY18
C	VAL19
C	GLY20
C	LYS21
C	THR22
C	SER23
C	PHE33
C	SER34
C	ASN35
C	TYR37
C	THR40
C	GLY66
C	ASN125
C	LYS126
C	ASP128
C	LEU129
C	SER155
C	ALA156
C	LYS157
C	MG1301
C	HOH1403
C	HOH1407
C	HOH1423

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VIIlGDSGVGKtsL

Chain	Residue	Details
A	VAL11-LEU24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1T91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15933719","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20028791","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LAW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by LRRK1","evidences":[{"source":"PubMed","id":"36040231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	58
Details	Repeat: {"description":"ANK 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	58
Details	Repeat: {"description":"ANK 2"}

Chain

Residue

Details

---