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6IYB

Structure of human ORP1 ANK - Rab7 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000421cellular_componentautophagosome membrane
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005794cellular_componentGolgi apparatus
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006622biological_processprotein targeting to lysosome
A0006897biological_processendocytosis
A0006914biological_processautophagy
A0007174biological_processepidermal growth factor catabolic process
A0008333biological_processendosome to lysosome transport
A0009617biological_processresponse to bacterium
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019076biological_processviral release from host cell
A0022615biological_processprotein to membrane docking
A0030667cellular_componentsecretory granule membrane
A0030670cellular_componentphagocytic vesicle membrane
A0030672cellular_componentsynaptic vesicle membrane
A0030904cellular_componentretromer complex
A0031267molecular_functionsmall GTPase binding
A0031902cellular_componentlate endosome membrane
A0031966cellular_componentmitochondrial membrane
A0033162cellular_componentmelanosome membrane
A0034045cellular_componentphagophore assembly site membrane
A0042147biological_processretrograde transport, endosome to Golgi
A0043231cellular_componentintracellular membrane-bounded organelle
A0045022biological_processearly endosome to late endosome transport
A0045335cellular_componentphagocytic vesicle
A0045453biological_processbone resorption
A0045732biological_processpositive regulation of protein catabolic process
A0046907biological_processintracellular transport
A0048524biological_processpositive regulation of viral process
A0051650biological_processestablishment of vesicle localization
A0061724biological_processlipophagy
A0070062cellular_componentextracellular exosome
A0090382biological_processphagosome maturation
A0090383biological_processphagosome acidification
A0090385biological_processphagosome-lysosome fusion
A0097208cellular_componentalveolar lamellar body
A0099638biological_processendosome to plasma membrane protein transport
A1903542biological_processnegative regulation of exosomal secretion
A1903543biological_processpositive regulation of exosomal secretion
A1905366biological_processnegative regulation of intralumenal vesicle formation
A1905394molecular_functionretromer complex binding
C0000045biological_processautophagosome assembly
C0000421cellular_componentautophagosome membrane
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005770cellular_componentlate endosome
C0005794cellular_componentGolgi apparatus
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006622biological_processprotein targeting to lysosome
C0006897biological_processendocytosis
C0006914biological_processautophagy
C0007174biological_processepidermal growth factor catabolic process
C0008333biological_processendosome to lysosome transport
C0009617biological_processresponse to bacterium
C0010008cellular_componentendosome membrane
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0016042biological_processlipid catabolic process
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0019076biological_processviral release from host cell
C0022615biological_processprotein to membrane docking
C0030667cellular_componentsecretory granule membrane
C0030670cellular_componentphagocytic vesicle membrane
C0030672cellular_componentsynaptic vesicle membrane
C0030904cellular_componentretromer complex
C0031267molecular_functionsmall GTPase binding
C0031902cellular_componentlate endosome membrane
C0031966cellular_componentmitochondrial membrane
C0033162cellular_componentmelanosome membrane
C0034045cellular_componentphagophore assembly site membrane
C0042147biological_processretrograde transport, endosome to Golgi
C0043231cellular_componentintracellular membrane-bounded organelle
C0045022biological_processearly endosome to late endosome transport
C0045335cellular_componentphagocytic vesicle
C0045453biological_processbone resorption
C0045732biological_processpositive regulation of protein catabolic process
C0046907biological_processintracellular transport
C0048524biological_processpositive regulation of viral process
C0051650biological_processestablishment of vesicle localization
C0061724biological_processlipophagy
C0070062cellular_componentextracellular exosome
C0090382biological_processphagosome maturation
C0090383biological_processphagosome acidification
C0090385biological_processphagosome-lysosome fusion
C0097208cellular_componentalveolar lamellar body
C0099638biological_processendosome to plasma membrane protein transport
C1903542biological_processnegative regulation of exosomal secretion
C1903543biological_processpositive regulation of exosomal secretion
C1905366biological_processnegative regulation of intralumenal vesicle formation
C1905394molecular_functionretromer complex binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MG A 1301
ChainResidue
ATHR22
ATHR40
AGTP1302
AHOH1425
AHOH1431

site_idAC2
Number of Residues25
Detailsbinding site for residue GTP A 1302
ChainResidue
ALYS21
ATHR22
ASER23
APHE33
ASER34
AASN35
ATYR37
ATHR40
AGLY66
AASN125
ALYS126
AASP128
ALEU129
ASER155
AALA156
ALYS157
AMG1301
AHOH1413
AHOH1425
AHOH1431
AHOH1458
ASER17
AGLY18
AVAL19
AGLY20

site_idAC3
Number of Residues5
Detailsbinding site for residue MG C 1301
ChainResidue
CTHR22
CTHR40
CGTP1302
CHOH1403
CHOH1407

site_idAC4
Number of Residues24
Detailsbinding site for residue GTP C 1302
ChainResidue
CSER17
CGLY18
CVAL19
CGLY20
CLYS21
CTHR22
CSER23
CPHE33
CSER34
CASN35
CTYR37
CTHR40
CGLY66
CASN125
CLYS126
CASP128
CLEU129
CSER155
CALA156
CLYS157
CMG1301
CHOH1403
CHOH1407
CHOH1423

Functional Information from PROSITE/UniProt
site_idPS00675
Number of Residues14
DetailsSIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VIIlGDSGVGKtsL
ChainResidueDetails
AVAL11-LEU24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:15933719, ECO:0000269|PubMed:20028791
ChainResidueDetails
AGLY15
CLYS157
ASER34
AASP63
ALYS126
ALYS157
CGLY15
CSER34
CASP63
CLYS126

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:25944712
ChainResidueDetails
ATHR2
CTHR2

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER72
CSER72

site_idSWS_FT_FI4
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874
ChainResidueDetails
ALEU192
AASN195
CLEU192
CASN195

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PDB entries from 2024-07-24

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