6IOL

Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009279	cellular_component	cell outer membrane
A	0015297	molecular_function	antiporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0009279	cellular_component	cell outer membrane
B	0015297	molecular_function	antiporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0009279	cellular_component	cell outer membrane
C	0015297	molecular_function	antiporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0009636	biological_process	response to toxic substance
E	0015297	molecular_function	antiporter activity
E	0015562	molecular_function	efflux transmembrane transporter activity
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0042908	biological_process	xenobiotic transport
E	0042910	molecular_function	xenobiotic transmembrane transporter activity
E	0046677	biological_process	response to antibiotic
E	0055085	biological_process	transmembrane transport
E	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
E	1990281	cellular_component	efflux pump complex
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0009636	biological_process	response to toxic substance
F	0015297	molecular_function	antiporter activity
F	0015562	molecular_function	efflux transmembrane transporter activity
F	0016020	cellular_component	membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0042908	biological_process	xenobiotic transport
F	0042910	molecular_function	xenobiotic transmembrane transporter activity
F	0046677	biological_process	response to antibiotic
F	0055085	biological_process	transmembrane transport
F	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
F	1990281	cellular_component	efflux pump complex
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0009636	biological_process	response to toxic substance
G	0015297	molecular_function	antiporter activity
G	0015562	molecular_function	efflux transmembrane transporter activity
G	0016020	cellular_component	membrane
G	0022857	molecular_function	transmembrane transporter activity
G	0042908	biological_process	xenobiotic transport
G	0042910	molecular_function	xenobiotic transmembrane transporter activity
G	0046677	biological_process	response to antibiotic
G	0055085	biological_process	transmembrane transport
G	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
G	1990281	cellular_component	efflux pump complex
I	0005886	cellular_component	plasma membrane
I	0009636	biological_process	response to toxic substance
I	0015297	molecular_function	antiporter activity
I	0015562	molecular_function	efflux transmembrane transporter activity
I	0016020	cellular_component	membrane
I	0022857	molecular_function	transmembrane transporter activity
I	0042802	molecular_function	identical protein binding
I	0042908	biological_process	xenobiotic transport
I	0046677	biological_process	response to antibiotic
I	0051260	biological_process	protein homooligomerization
I	0055085	biological_process	transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0009636	biological_process	response to toxic substance
J	0015297	molecular_function	antiporter activity
J	0015562	molecular_function	efflux transmembrane transporter activity
J	0016020	cellular_component	membrane
J	0022857	molecular_function	transmembrane transporter activity
J	0042802	molecular_function	identical protein binding
J	0042908	biological_process	xenobiotic transport
J	0046677	biological_process	response to antibiotic
J	0051260	biological_process	protein homooligomerization
J	0055085	biological_process	transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0009636	biological_process	response to toxic substance
K	0015297	molecular_function	antiporter activity
K	0015562	molecular_function	efflux transmembrane transporter activity
K	0016020	cellular_component	membrane
K	0022857	molecular_function	transmembrane transporter activity
K	0042802	molecular_function	identical protein binding
K	0042908	biological_process	xenobiotic transport
K	0046677	biological_process	response to antibiotic
K	0051260	biological_process	protein homooligomerization
K	0055085	biological_process	transmembrane transport
L	0005886	cellular_component	plasma membrane
L	0009636	biological_process	response to toxic substance
L	0015297	molecular_function	antiporter activity
L	0015562	molecular_function	efflux transmembrane transporter activity
L	0016020	cellular_component	membrane
L	0022857	molecular_function	transmembrane transporter activity
L	0042802	molecular_function	identical protein binding
L	0042908	biological_process	xenobiotic transport
L	0046677	biological_process	response to antibiotic
L	0051260	biological_process	protein homooligomerization
L	0055085	biological_process	transmembrane transport
M	0005886	cellular_component	plasma membrane
M	0009636	biological_process	response to toxic substance
M	0015297	molecular_function	antiporter activity
M	0015562	molecular_function	efflux transmembrane transporter activity
M	0016020	cellular_component	membrane
M	0022857	molecular_function	transmembrane transporter activity
M	0042802	molecular_function	identical protein binding
M	0042908	biological_process	xenobiotic transport
M	0046677	biological_process	response to antibiotic
M	0051260	biological_process	protein homooligomerization
M	0055085	biological_process	transmembrane transport
N	0005886	cellular_component	plasma membrane
N	0009636	biological_process	response to toxic substance
N	0015297	molecular_function	antiporter activity
N	0015562	molecular_function	efflux transmembrane transporter activity
N	0016020	cellular_component	membrane
N	0022857	molecular_function	transmembrane transporter activity
N	0042802	molecular_function	identical protein binding
N	0042908	biological_process	xenobiotic transport
N	0046677	biological_process	response to antibiotic
N	0051260	biological_process	protein homooligomerization
N	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	324
Details	Coiled coil: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Lipidation: {"description":"S-diacylglycerol cysteine","evidences":[{"source":"PubMed","id":"10889211","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	295
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10187844","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	702
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1971
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"10187844","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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