6IM9
MDM2 bound CueO-PM2 sensor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004322 | molecular_function | ferroxidase activity |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0010273 | biological_process | detoxification of copper ion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
| A | 0016722 | molecular_function | oxidoreductase activity, acting on metal ions |
| A | 0016724 | molecular_function | oxidoreductase activity, acting on metal ions, oxygen as acceptor |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046688 | biological_process | response to copper ion |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PROSITE/UniProt
| site_id | PS00080 |
| Number of Residues | 12 |
| Details | MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHlleHedtGM |
| Chain | Residue | Details |
| A | HIS499-MET510 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 110 |
| Details | Domain: {"description":"Plastocyanin-like 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 65 |
| Details | Domain: {"description":"Plastocyanin-like 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 114 |
| Details | Domain: {"description":"Plastocyanin-like 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 45 |
| Details | Region: {"description":"Methionine-rich region","evidences":[{"source":"PubMed","id":"11867755","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"type 2 copper site","evidences":[{"source":"PubMed","id":"11867755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12794077","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17217912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17804014","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903583","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24598746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"type 3 copper site","evidences":[{"source":"PubMed","id":"11867755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12794077","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17217912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17804014","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903583","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24598746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"11867755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12794077","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17217912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17804014","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903583","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24598746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 83 |
| Details | Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
