Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0020037 | molecular_function | heme binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0020037 | molecular_function | heme binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | LYS69 |
| A | PHE331 |
| A | PRO392 |
| A | PHE393 |
| A | GLY394 |
| A | ARG398 |
| A | ALA399 |
| A | CYS400 |
| A | ILE401 |
| A | GLY402 |
| A | ALA406 |
| A | LEU86 |
| A | DTT502 |
| A | HOH616 |
| A | HOH619 |
| A | HOH620 |
| A | HOH625 |
| A | HOH771 |
| A | HOH859 |
| A | VAL87 |
| A | TRP96 |
| A | ALA264 |
| A | GLY265 |
| A | THR268 |
| A | THR269 |
| A | THR327 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue DTT A 502 |
| Chain | Residue |
| A | ALA264 |
| A | HEM501 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | LYS391 |
| A | ASN395 |
| A | GLY396 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | GLY396 |
| A | GLN397 |
| A | HOH895 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 506 |
| Chain | Residue |
| A | LYS440 |
| A | GLY443 |
| A | HOH889 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 507 |
| Chain | Residue |
| A | PHE279 |
| A | ASN283 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 508 |
| Chain | Residue |
| A | ARG223 |
| A | THR235 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 509 |
| Chain | Residue |
| A | ARG190 |
| A | ALA191 |
| A | ASN192 |
| B | ALA191 |
| B | ASN192 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 510 |
| Chain | Residue |
| A | ARG79 |
| A | TYR256 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 511 |
| Chain | Residue |
| A | PRO196 |
| A | HOH606 |
| A | HOH870 |
| B | ASP23 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 512 |
| Chain | Residue |
| A | TRP90 |
| A | HIS92 |
| A | GLY350 |
| B | GLY342 |
| B | GLU344 |
| site_id | AD3 |
| Number of Residues | 26 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | LYS69 |
| B | LEU75 |
| B | LEU86 |
| B | VAL87 |
| B | TRP96 |
| B | ALA264 |
| B | GLY265 |
| B | THR268 |
| B | THR269 |
| B | THR327 |
| B | PHE331 |
| B | PRO392 |
| B | PHE393 |
| B | GLY394 |
| B | ARG398 |
| B | ALA399 |
| B | CYS400 |
| B | ILE401 |
| B | GLY402 |
| B | DTT502 |
| B | HOH613 |
| B | HOH630 |
| B | HOH643 |
| B | HOH667 |
| B | HOH698 |
| B | HOH742 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue DTT B 502 |
| Chain | Residue |
| B | ALA264 |
| B | HEM501 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 503 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | GLY396 |
| B | GLN397 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 505 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 506 |
| Chain | Residue |
| B | ASN283 |
| B | PRO284 |
| B | TYR285 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 507 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 508 |
| Chain | Residue |
| B | ARG79 |
| B | ASP84 |
| B | GLU252 |
| B | TYR256 |
| B | HOH753 |
| site_id | AE2 |
| Number of Residues | 28 |
| Details | binding site for residue HEM C 501 |
| Chain | Residue |
| C | LEU86 |
| C | VAL87 |
| C | TRP96 |
| C | PHE261 |
| C | ALA264 |
| C | GLY265 |
| C | THR268 |
| C | THR269 |
| C | LEU272 |
| C | THR327 |
| C | PHE331 |
| C | PRO392 |
| C | PHE393 |
| C | GLY394 |
| C | ARG398 |
| C | ALA399 |
| C | CYS400 |
| C | ILE401 |
| C | GLY402 |
| C | ALA406 |
| C | DTT502 |
| C | HOH623 |
| C | HOH640 |
| C | HOH663 |
| C | HOH681 |
| C | HOH740 |
| C | HOH788 |
| C | LYS69 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue DTT C 502 |
| Chain | Residue |
| C | VAL87 |
| C | HEM501 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 503 |
| Chain | Residue |
| C | ASN283 |
| C | PRO284 |
| C | TYR285 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 504 |
| Chain | Residue |
| C | LYS391 |
| C | ASN395 |
| C | GLY396 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 505 |
| Chain | Residue |
| C | GLY396 |
| C | GLN397 |
| C | HOH727 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 506 |
| Chain | Residue |
| C | PRO142 |
| C | LYS440 |
| C | GLY443 |
| C | HOH789 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 507 |
| Chain | Residue |
| C | ARG79 |
| C | GLY83 |
| C | ASP84 |
| C | TYR256 |
| C | HOH653 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 508 |
| Chain | Residue |
| C | TRP90 |
| C | HIS92 |
| C | TYR334 |
| C | HOH652 |
| site_id | AF1 |
| Number of Residues | 25 |
| Details | binding site for residue HEM D 501 |
| Chain | Residue |
| D | LYS69 |
| D | LEU86 |
| D | VAL87 |
| D | TRP96 |
| D | PHE261 |
| D | ALA264 |
| D | GLY265 |
| D | THR268 |
| D | THR269 |
| D | THR327 |
| D | PHE331 |
| D | PRO392 |
| D | PHE393 |
| D | GLY394 |
| D | ARG398 |
| D | ALA399 |
| D | CYS400 |
| D | ILE401 |
| D | ALA406 |
| D | DTT502 |
| D | HOH611 |
| D | HOH636 |
| D | HOH665 |
| D | HOH681 |
| D | HOH777 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue DTT D 502 |
| Chain | Residue |
| D | ALA264 |
| D | LEU437 |
| D | HEM501 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 503 |
| Chain | Residue |
| D | PHE279 |
| D | ASN283 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 504 |
| Chain | Residue |
| D | ASN283 |
| D | PRO284 |
| D | TYR285 |
| D | HOH861 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 505 |
| Chain | Residue |
| D | GLY396 |
| D | GLN397 |
| D | HOH782 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 506 |
| Chain | Residue |
| D | GLU137 |
| D | HIS138 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 507 |
| Chain | Residue |
| D | GLY443 |
| D | HOH824 |
| site_id | AF8 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide DTT A 503 and CYS B 198 |
| Chain | Residue |
| A | ARG190 |
| A | PRO193 |
| A | ASP195 |
| A | PRO196 |
| A | ALA197 |
| A | ASP199 |
| A | GLU200 |
| A | ASN201 |
| A | LYS202 |
| A | HOH653 |
| B | LYS94 |
| B | ARG190 |
| B | PRO193 |
| B | ASP195 |
| B | PRO196 |
| B | ALA197 |
| B | ASP199 |
| B | GLU200 |
| B | ASN201 |
| B | LYS202 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGnGQRACIG |
| Chain | Residue | Details |
| A | PHE393-GLY402 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR51 | |
| B | TYR51 | |
| C | TYR51 | |
| D | TYR51 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:10051560, ECO:0000269|PubMed:11695889, ECO:0000269|PubMed:11695892, ECO:0000269|PubMed:14653735, ECO:0000269|PubMed:15020590, ECO:0000269|PubMed:15299332, ECO:0000269|PubMed:16403573, ECO:0000269|PubMed:17077084, ECO:0000269|PubMed:17429965, ECO:0000269|PubMed:17868686, ECO:0000269|PubMed:18004886, ECO:0000269|PubMed:18298086, ECO:0000269|PubMed:18619466, ECO:0000269|PubMed:18721129, ECO:0000269|PubMed:19492389, ECO:0000269|PubMed:20180779, ECO:0000269|PubMed:20947800, ECO:0000269|PubMed:21110374, ECO:0000269|PubMed:21875028, ECO:0000269|PubMed:7578081, ECO:0000269|PubMed:8342039, ECO:0000269|PubMed:9033595, ECO:0007744|PDB:1BU7, ECO:0007744|PDB:1BVY, ECO:0007744|PDB:1FAG, ECO:0007744|PDB:1FAH, ECO:0007744|PDB:1JME, ECO:0007744|PDB:1JPZ, ECO:0007744|PDB:1P0V, ECO:0007744|PDB:1P0W, ECO:0007744|PDB:1P0X, ECO:0007744|PDB:1SMI, ECO:0007744|PDB:1SMJ, ECO:0007744|PDB:1YQO, ECO:0007744|PDB:1YQP, ECO:0007744|PDB:1ZO4, ECO:0007744|PDB:1ZO9, ECO:0007744|PDB:1ZOA, ECO:0007744|PDB:2BMH, ECO:0007744|PDB:2HPD, ECO:0007744|PDB:2IJ2, ECO:0007744|PDB:2IJ3, ECO:0007744|PDB:2IJ4, ECO:0007744|PDB:2J1M, ECO:0007744|PDB:2J4S, ECO:0007744|PDB:2UWH, ECO:0007744|PDB:3BEN, ECO:0007744|PDB:3CBD, ECO:0007744|PDB:3EKB, ECO:0007744|PDB:3EKD, ECO:0007744|PDB:3EKF, ECO:0007744|PDB:3HF2, ECO:0007744|PDB:3KX3, ECO:0007744|PDB:3KX4, ECO:0007744|PDB:3KX5, ECO:0007744|PDB:3M4V, ECO:0007744|PDB:3NPL |
| Chain | Residue | Details |
| A | CYS400 | |
| B | CYS400 | |
| C | CYS400 | |
| D | CYS400 | |
| Chain | Residue | Details |
| A | THR268 | |
| B | THR268 | |
| C | THR268 | |
| D | THR268 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 699 |
| Chain | Residue | Details |
| A | THR268 | electrostatic stabiliser, steric role |
| A | PHE393 | electrostatic stabiliser, steric role |
| A | CYS400 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 699 |
| Chain | Residue | Details |
| B | THR268 | electrostatic stabiliser, steric role |
| B | PHE393 | electrostatic stabiliser, steric role |
| B | CYS400 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 699 |
| Chain | Residue | Details |
| C | THR268 | electrostatic stabiliser, steric role |
| C | PHE393 | electrostatic stabiliser, steric role |
| C | CYS400 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 699 |
| Chain | Residue | Details |
| D | THR268 | electrostatic stabiliser, steric role |
| D | PHE393 | electrostatic stabiliser, steric role |
| D | CYS400 | electrostatic stabiliser |
