Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0020037 | molecular_function | heme binding |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
B | 0020037 | molecular_function | heme binding |
C | 0004497 | molecular_function | monooxygenase activity |
C | 0005506 | molecular_function | iron ion binding |
C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
C | 0020037 | molecular_function | heme binding |
D | 0004497 | molecular_function | monooxygenase activity |
D | 0005506 | molecular_function | iron ion binding |
D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
D | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | binding site for residue HEM A 501 |
Chain | Residue |
A | LYS69 |
A | PHE331 |
A | PRO392 |
A | PHE393 |
A | GLY394 |
A | ARG398 |
A | ALA399 |
A | CYS400 |
A | ILE401 |
A | GLY402 |
A | ALA406 |
A | LEU86 |
A | DTT502 |
A | HOH616 |
A | HOH619 |
A | HOH620 |
A | HOH625 |
A | HOH771 |
A | HOH859 |
A | VAL87 |
A | TRP96 |
A | ALA264 |
A | GLY265 |
A | THR268 |
A | THR269 |
A | THR327 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue DTT A 502 |
Chain | Residue |
A | ALA264 |
A | HEM501 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL A 504 |
Chain | Residue |
A | LYS391 |
A | ASN395 |
A | GLY396 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue CL A 505 |
Chain | Residue |
A | GLY396 |
A | GLN397 |
A | HOH895 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue CL A 506 |
Chain | Residue |
A | LYS440 |
A | GLY443 |
A | HOH889 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue CL A 507 |
Chain | Residue |
A | PHE279 |
A | ASN283 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue CL A 508 |
Chain | Residue |
A | ARG223 |
A | THR235 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue CL A 509 |
Chain | Residue |
A | ARG190 |
A | ALA191 |
A | ASN192 |
B | ALA191 |
B | ASN192 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue GOL A 510 |
Chain | Residue |
A | ARG79 |
A | TYR256 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue GOL A 511 |
Chain | Residue |
A | PRO196 |
A | HOH606 |
A | HOH870 |
B | ASP23 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue PEG A 512 |
Chain | Residue |
A | TRP90 |
A | HIS92 |
A | GLY350 |
B | GLY342 |
B | GLU344 |
site_id | AD3 |
Number of Residues | 26 |
Details | binding site for residue HEM B 501 |
Chain | Residue |
B | LYS69 |
B | LEU75 |
B | LEU86 |
B | VAL87 |
B | TRP96 |
B | ALA264 |
B | GLY265 |
B | THR268 |
B | THR269 |
B | THR327 |
B | PHE331 |
B | PRO392 |
B | PHE393 |
B | GLY394 |
B | ARG398 |
B | ALA399 |
B | CYS400 |
B | ILE401 |
B | GLY402 |
B | DTT502 |
B | HOH613 |
B | HOH630 |
B | HOH643 |
B | HOH667 |
B | HOH698 |
B | HOH742 |
site_id | AD4 |
Number of Residues | 2 |
Details | binding site for residue DTT B 502 |
Chain | Residue |
B | ALA264 |
B | HEM501 |
site_id | AD5 |
Number of Residues | 1 |
Details | binding site for residue CL B 503 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue CL B 504 |
Chain | Residue |
B | GLY396 |
B | GLN397 |
site_id | AD7 |
Number of Residues | 1 |
Details | binding site for residue CL B 505 |
site_id | AD8 |
Number of Residues | 3 |
Details | binding site for residue CL B 506 |
Chain | Residue |
B | ASN283 |
B | PRO284 |
B | TYR285 |
site_id | AD9 |
Number of Residues | 1 |
Details | binding site for residue CL B 507 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue GOL B 508 |
Chain | Residue |
B | ARG79 |
B | ASP84 |
B | GLU252 |
B | TYR256 |
B | HOH753 |
site_id | AE2 |
Number of Residues | 28 |
Details | binding site for residue HEM C 501 |
Chain | Residue |
C | LEU86 |
C | VAL87 |
C | TRP96 |
C | PHE261 |
C | ALA264 |
C | GLY265 |
C | THR268 |
C | THR269 |
C | LEU272 |
C | THR327 |
C | PHE331 |
C | PRO392 |
C | PHE393 |
C | GLY394 |
C | ARG398 |
C | ALA399 |
C | CYS400 |
C | ILE401 |
C | GLY402 |
C | ALA406 |
C | DTT502 |
C | HOH623 |
C | HOH640 |
C | HOH663 |
C | HOH681 |
C | HOH740 |
C | HOH788 |
C | LYS69 |
site_id | AE3 |
Number of Residues | 2 |
Details | binding site for residue DTT C 502 |
Chain | Residue |
C | VAL87 |
C | HEM501 |
site_id | AE4 |
Number of Residues | 3 |
Details | binding site for residue CL C 503 |
Chain | Residue |
C | ASN283 |
C | PRO284 |
C | TYR285 |
site_id | AE5 |
Number of Residues | 3 |
Details | binding site for residue CL C 504 |
Chain | Residue |
C | LYS391 |
C | ASN395 |
C | GLY396 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue CL C 505 |
Chain | Residue |
C | GLY396 |
C | GLN397 |
C | HOH727 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue CL C 506 |
Chain | Residue |
C | PRO142 |
C | LYS440 |
C | GLY443 |
C | HOH789 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue GOL C 507 |
Chain | Residue |
C | ARG79 |
C | GLY83 |
C | ASP84 |
C | TYR256 |
C | HOH653 |
site_id | AE9 |
Number of Residues | 4 |
Details | binding site for residue PEG C 508 |
Chain | Residue |
C | TRP90 |
C | HIS92 |
C | TYR334 |
C | HOH652 |
site_id | AF1 |
Number of Residues | 25 |
Details | binding site for residue HEM D 501 |
Chain | Residue |
D | LYS69 |
D | LEU86 |
D | VAL87 |
D | TRP96 |
D | PHE261 |
D | ALA264 |
D | GLY265 |
D | THR268 |
D | THR269 |
D | THR327 |
D | PHE331 |
D | PRO392 |
D | PHE393 |
D | GLY394 |
D | ARG398 |
D | ALA399 |
D | CYS400 |
D | ILE401 |
D | ALA406 |
D | DTT502 |
D | HOH611 |
D | HOH636 |
D | HOH665 |
D | HOH681 |
D | HOH777 |
site_id | AF2 |
Number of Residues | 3 |
Details | binding site for residue DTT D 502 |
Chain | Residue |
D | ALA264 |
D | LEU437 |
D | HEM501 |
site_id | AF3 |
Number of Residues | 2 |
Details | binding site for residue CL D 503 |
Chain | Residue |
D | PHE279 |
D | ASN283 |
site_id | AF4 |
Number of Residues | 4 |
Details | binding site for residue CL D 504 |
Chain | Residue |
D | ASN283 |
D | PRO284 |
D | TYR285 |
D | HOH861 |
site_id | AF5 |
Number of Residues | 3 |
Details | binding site for residue CL D 505 |
Chain | Residue |
D | GLY396 |
D | GLN397 |
D | HOH782 |
site_id | AF6 |
Number of Residues | 2 |
Details | binding site for residue CL D 506 |
Chain | Residue |
D | GLU137 |
D | HIS138 |
site_id | AF7 |
Number of Residues | 2 |
Details | binding site for residue CL D 507 |
Chain | Residue |
D | GLY443 |
D | HOH824 |
site_id | AF8 |
Number of Residues | 20 |
Details | binding site for Di-peptide DTT A 503 and CYS B 198 |
Chain | Residue |
A | ARG190 |
A | PRO193 |
A | ASP195 |
A | PRO196 |
A | ALA197 |
A | ASP199 |
A | GLU200 |
A | ASN201 |
A | LYS202 |
A | HOH653 |
B | LYS94 |
B | ARG190 |
B | PRO193 |
B | ASP195 |
B | PRO196 |
B | ALA197 |
B | ASP199 |
B | GLU200 |
B | ASN201 |
B | LYS202 |
Functional Information from PROSITE/UniProt
site_id | PS00086 |
Number of Residues | 10 |
Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGnGQRACIG |
Chain | Residue | Details |
A | PHE393-GLY402 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | TYR51 | |
B | TYR51 | |
C | TYR51 | |
D | TYR51 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:10051560, ECO:0000269|PubMed:11695889, ECO:0000269|PubMed:11695892, ECO:0000269|PubMed:14653735, ECO:0000269|PubMed:15020590, ECO:0000269|PubMed:15299332, ECO:0000269|PubMed:16403573, ECO:0000269|PubMed:17077084, ECO:0000269|PubMed:17429965, ECO:0000269|PubMed:17868686, ECO:0000269|PubMed:18004886, ECO:0000269|PubMed:18298086, ECO:0000269|PubMed:18619466, ECO:0000269|PubMed:18721129, ECO:0000269|PubMed:19492389, ECO:0000269|PubMed:20180779, ECO:0000269|PubMed:20947800, ECO:0000269|PubMed:21110374, ECO:0000269|PubMed:21875028, ECO:0000269|PubMed:7578081, ECO:0000269|PubMed:8342039, ECO:0000269|PubMed:9033595, ECO:0007744|PDB:1BU7, ECO:0007744|PDB:1BVY, ECO:0007744|PDB:1FAG, ECO:0007744|PDB:1FAH, ECO:0007744|PDB:1JME, ECO:0007744|PDB:1JPZ, ECO:0007744|PDB:1P0V, ECO:0007744|PDB:1P0W, ECO:0007744|PDB:1P0X, ECO:0007744|PDB:1SMI, ECO:0007744|PDB:1SMJ, ECO:0007744|PDB:1YQO, ECO:0007744|PDB:1YQP, ECO:0007744|PDB:1ZO4, ECO:0007744|PDB:1ZO9, ECO:0007744|PDB:1ZOA, ECO:0007744|PDB:2BMH, ECO:0007744|PDB:2HPD, ECO:0007744|PDB:2IJ2, ECO:0007744|PDB:2IJ3, ECO:0007744|PDB:2IJ4, ECO:0007744|PDB:2J1M, ECO:0007744|PDB:2J4S, ECO:0007744|PDB:2UWH, ECO:0007744|PDB:3BEN, ECO:0007744|PDB:3CBD, ECO:0007744|PDB:3EKB, ECO:0007744|PDB:3EKD, ECO:0007744|PDB:3EKF, ECO:0007744|PDB:3HF2, ECO:0007744|PDB:3KX3, ECO:0007744|PDB:3KX4, ECO:0007744|PDB:3KX5, ECO:0007744|PDB:3M4V, ECO:0007744|PDB:3NPL |
Chain | Residue | Details |
A | CYS400 | |
B | CYS400 | |
C | CYS400 | |
D | CYS400 | |
Chain | Residue | Details |
A | THR268 | |
B | THR268 | |
C | THR268 | |
D | THR268 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
A | THR268 | electrostatic stabiliser, steric role |
A | PHE393 | electrostatic stabiliser, steric role |
A | CYS400 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
B | THR268 | electrostatic stabiliser, steric role |
B | PHE393 | electrostatic stabiliser, steric role |
B | CYS400 | electrostatic stabiliser |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
C | THR268 | electrostatic stabiliser, steric role |
C | PHE393 | electrostatic stabiliser, steric role |
C | CYS400 | electrostatic stabiliser |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 699 |
Chain | Residue | Details |
D | THR268 | electrostatic stabiliser, steric role |
D | PHE393 | electrostatic stabiliser, steric role |
D | CYS400 | electrostatic stabiliser |