6I7L
Crystal structure of monomeric FICD mutant L258D complexed with MgAMP-PNP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue ANP A 501 |
| Chain | Residue |
| A | THR230 |
| A | ASN369 |
| A | GLY370 |
| A | ARG371 |
| A | ARG374 |
| A | TYR399 |
| A | TYR400 |
| A | ASN407 |
| A | MG502 |
| A | HOH607 |
| A | HOH672 |
| A | ILE233 |
| A | HOH681 |
| A | GLU234 |
| A | VAL316 |
| A | HIS319 |
| A | VAL360 |
| A | HIS363 |
| A | ASP367 |
| A | GLY368 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | ASP367 |
| A | ANP501 |
| A | HOH668 |
| A | HOH672 |
| A | HOH681 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 135 |
| Details | Domain: {"description":"Fido","evidences":[{"source":"PROSITE-ProRule","id":"PRU00791","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Motif: {"description":"Inhibitory (S/T)XXXE(G/N) motif","evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for autoinhibition of adenylyltransferase activity","evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-AMP-threonine; by autocatalysis","evidences":[{"source":"PubMed","id":"25601083","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25601083","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
