6I3Y
Crystal structure of the human mitochondrial PRELID1K58V-TRIAP1 complex with PS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002039 | molecular_function | p53 binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0030330 | biological_process | DNA damage response, signal transduction by p53 class mediator |
| A | 0031571 | biological_process | mitotic G1 DNA damage checkpoint signaling |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034644 | biological_process | cellular response to UV |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0090201 | biological_process | negative regulation of release of cytochrome c from mitochondria |
| A | 0097035 | biological_process | regulation of membrane lipid distribution |
| A | 1902166 | biological_process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| A | 1990050 | molecular_function | phosphatidic acid transfer activity |
| A | 2001140 | biological_process | positive regulation of phospholipid transport |
| C | 0005758 | cellular_component | mitochondrial intermembrane space |
| F | 0005758 | cellular_component | mitochondrial intermembrane space |
| H | 0002039 | molecular_function | p53 binding |
| H | 0005515 | molecular_function | protein binding |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005758 | cellular_component | mitochondrial intermembrane space |
| H | 0015914 | biological_process | phospholipid transport |
| H | 0030330 | biological_process | DNA damage response, signal transduction by p53 class mediator |
| H | 0031571 | biological_process | mitotic G1 DNA damage checkpoint signaling |
| H | 0032991 | cellular_component | protein-containing complex |
| H | 0034644 | biological_process | cellular response to UV |
| H | 0043066 | biological_process | negative regulation of apoptotic process |
| H | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| H | 0090201 | biological_process | negative regulation of release of cytochrome c from mitochondria |
| H | 0097035 | biological_process | regulation of membrane lipid distribution |
| H | 1902166 | biological_process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| H | 1990050 | molecular_function | phosphatidic acid transfer activity |
| H | 2001140 | biological_process | positive regulation of phospholipid transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue LMT C 201 |
| Chain | Residue |
| C | GLU120 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue P5S C 202 |
| Chain | Residue |
| C | VAL119 |
| C | GLU121 |
| F | ARG161 |
| C | ASN71 |
| C | MET73 |
| C | VAL89 |
| C | VAL91 |
| C | THR108 |
| C | ASN110 |
| C | HIS113 |
| C | MET117 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | binding site for residue P5S F 201 |
| Chain | Residue |
| C | ARG161 |
| C | ASN165 |
| C | THR169 |
| F | ARG36 |
| F | TYR37 |
| F | ASN39 |
| F | TYR41 |
| F | SER42 |
| F | HIS44 |
| F | VAL69 |
| F | THR70 |
| F | ASN71 |
| F | ARG72 |
| F | MET73 |
| F | VAL89 |
| F | VAL91 |
| F | ASN110 |
| F | HIS113 |
| F | MET117 |
| F | VAL119 |
| F | HOH302 |
| F | HOH304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Transit peptide: {"description":"Mitochondrion","evidences":[{"source":"PubMed","id":"14640972","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 102 |
| Details | Coiled coil: {"evidences":[{"source":"PubMed","id":"26071602","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for interaction with PRELID3A","evidences":[{"source":"PubMed","id":"26071602","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
