6I3Y

Crystal structure of the human mitochondrial PRELID1K58V-TRIAP1 complex with PS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002039	molecular_function	p53 binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006869	biological_process	lipid transport
A	0006915	biological_process	apoptotic process
A	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
A	0015914	biological_process	phospholipid transport
A	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0043066	biological_process	negative regulation of apoptotic process
A	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0045332	biological_process	phospholipid translocation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
A	0097035	biological_process	regulation of membrane lipid distribution
A	0120009	biological_process	intermembrane lipid transfer
A	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A	1990050	molecular_function	phosphatidic acid transfer activity
A	2001140	biological_process	positive regulation of phospholipid transport
C	0005758	cellular_component	mitochondrial intermembrane space
F	0005758	cellular_component	mitochondrial intermembrane space
H	0002039	molecular_function	p53 binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005739	cellular_component	mitochondrion
H	0005758	cellular_component	mitochondrial intermembrane space
H	0005829	cellular_component	cytosol
H	0006869	biological_process	lipid transport
H	0006915	biological_process	apoptotic process
H	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
H	0015914	biological_process	phospholipid transport
H	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
H	0032991	cellular_component	protein-containing complex
H	0034644	biological_process	cellular response to UV
H	0043066	biological_process	negative regulation of apoptotic process
H	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
H	0045332	biological_process	phospholipid translocation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
H	0097035	biological_process	regulation of membrane lipid distribution
H	0120009	biological_process	intermembrane lipid transfer
H	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
H	1990050	molecular_function	phosphatidic acid transfer activity
H	2001140	biological_process	positive regulation of phospholipid transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue LMT C 201

Chain	Residue
C	GLU120

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site_id	AC2
Number of Residues	11
Details	binding site for residue P5S C 202

Chain	Residue
C	VAL119
C	GLU121
F	ARG161
C	ASN71
C	MET73
C	VAL89
C	VAL91
C	THR108
C	ASN110
C	HIS113
C	MET117

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site_id	AC3
Number of Residues	22
Details	binding site for residue P5S F 201

Chain	Residue
C	ARG161
C	ASN165
C	THR169
F	ARG36
F	TYR37
F	ASN39
F	TYR41
F	SER42
F	HIS44
F	VAL69
F	THR70
F	ASN71
F	ARG72
F	MET73
F	VAL89
F	VAL91
F	ASN110
F	HIS113
F	MET117
F	VAL119
F	HOH302
F	HOH304

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Important for interaction with PRELID3A => ECO:0000269|PubMed:26071602

Chain	Residue	Details
A	PHE40
A	PHE54
H	PHE40
H	PHE54

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET14
H	MET14

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