6I3Y

Crystal structure of the human mitochondrial PRELID1K58V-TRIAP1 complex with PS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002039	molecular_function	p53 binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0006869	biological_process	lipid transport
A	0006915	biological_process	apoptotic process
A	0015914	biological_process	phospholipid transport
A	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
A	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0043066	biological_process	negative regulation of apoptotic process
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
A	0097035	biological_process	regulation of membrane lipid distribution
A	0120009	biological_process	intermembrane lipid transfer
A	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A	1990050	molecular_function	phosphatidic acid transfer activity
A	2001140	biological_process	positive regulation of phospholipid transport
C	0005758	cellular_component	mitochondrial intermembrane space
F	0005758	cellular_component	mitochondrial intermembrane space
H	0002039	molecular_function	p53 binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005758	cellular_component	mitochondrial intermembrane space
H	0006869	biological_process	lipid transport
H	0006915	biological_process	apoptotic process
H	0015914	biological_process	phospholipid transport
H	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
H	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
H	0032991	cellular_component	protein-containing complex
H	0034644	biological_process	cellular response to UV
H	0043066	biological_process	negative regulation of apoptotic process
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
H	0097035	biological_process	regulation of membrane lipid distribution
H	0120009	biological_process	intermembrane lipid transfer
H	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
H	1990050	molecular_function	phosphatidic acid transfer activity
H	2001140	biological_process	positive regulation of phospholipid transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue LMT C 201

Chain	Residue
C	GLU120

---

site_id	AC2
Number of Residues	11
Details	binding site for residue P5S C 202

Chain	Residue
C	VAL119
C	GLU121
F	ARG161
C	ASN71
C	MET73
C	VAL89
C	VAL91
C	THR108
C	ASN110
C	HIS113
C	MET117

---

site_id	AC3
Number of Residues	22
Details	binding site for residue P5S F 201

Chain	Residue
C	ARG161
C	ASN165
C	THR169
F	ARG36
F	TYR37
F	ASN39
F	TYR41
F	SER42
F	HIS44
F	VAL69
F	THR70
F	ASN71
F	ARG72
F	MET73
F	VAL89
F	VAL91
F	ASN110
F	HIS113
F	MET117
F	VAL119
F	HOH302
F	HOH304

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Transit peptide: {"description":"Mitochondrion","evidences":[{"source":"PubMed","id":"14640972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	100
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	102
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"26071602","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Important for interaction with PRELID3A","evidences":[{"source":"PubMed","id":"26071602","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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