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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6I3F

Crystal structure of the complex of human angiotensinogen and renin at 2.55 Angstrom

Functional Information from GO Data
ChainGOidnamespacecontents
A0001558biological_processregulation of cell growth
A0001819biological_processpositive regulation of cytokine production
A0001822biological_processkidney development
A0001974biological_processblood vessel remodeling
A0002016biological_processregulation of blood volume by renin-angiotensin
A0002018biological_processrenin-angiotensin regulation of aldosterone production
A0002019biological_processregulation of renal output by angiotensin
A0002034biological_processmaintenance of blood vessel diameter homeostasis by renin-angiotensin
A0003014biological_processrenal system process
A0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007186biological_processG protein-coupled receptor signaling pathway
A0007199biological_processG protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007267biological_processcell-cell signaling
A0008083molecular_functiongrowth factor activity
A0008217biological_processregulation of blood pressure
A0010595biological_processpositive regulation of endothelial cell migration
A0010613biological_processpositive regulation of cardiac muscle hypertrophy
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0014873biological_processresponse to muscle activity involved in regulation of muscle adaptation
A0019229biological_processregulation of vasoconstriction
A0031012cellular_componentextracellular matrix
A0031702molecular_functiontype 1 angiotensin receptor binding
A0031703molecular_functiontype 2 angiotensin receptor binding
A0034374biological_processlow-density lipoprotein particle remodeling
A0035813biological_processregulation of renal sodium excretion
A0038060biological_processnitric oxide-cGMP-mediated signaling
A0038166biological_processangiotensin-activated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042310biological_processvasoconstriction
A0042981biological_processregulation of apoptotic process
A0043407biological_processnegative regulation of MAP kinase activity
A0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
A0045893biological_processpositive regulation of DNA-templated transcription
A0048146biological_processpositive regulation of fibroblast proliferation
A0050729biological_processpositive regulation of inflammatory response
A0051387biological_processnegative regulation of neurotrophin TRK receptor signaling pathway
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070062cellular_componentextracellular exosome
A0072562cellular_componentblood microparticle
A0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
A0090205biological_processpositive regulation of cholesterol metabolic process
A0097746biological_processblood vessel diameter maintenance
A1901201biological_processregulation of extracellular matrix assembly
A1901203biological_processpositive regulation of extracellular matrix assembly
A1902895biological_processpositive regulation of miRNA transcription
A1903598biological_processpositive regulation of gap junction assembly
A1903779biological_processregulation of cardiac conduction
A1990776biological_processresponse to angiotensin
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
ChainResidueDetails
BVAL35-VAL46
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. VTLNRPFLFaV
ChainResidueDetails
AVAL421-VAL431
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsPeptide: {"description":"Angiotensin-1","featureId":"PRO_0000032457","evidences":[{"source":"PubMed","id":"4300938","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsPeptide: {"description":"Angiotensin 1-9","featureId":"PRO_0000420659","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsPeptide: {"description":"Angiotensin-2","featureId":"PRO_0000032458","evidences":[{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9492317","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsPeptide: {"description":"Angiotensin 1-7","featureId":"PRO_0000420660","evidences":[{"source":"PubMed","id":"15283675","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsPeptide: {"description":"Angiotensin 1-5","featureId":"PRO_0000420661","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsPeptide: {"description":"Angiotensin 1-4","featureId":"PRO_0000420662","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsPeptide: {"description":"Angiotensin-3","featureId":"PRO_0000032459","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"1132082","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues5
DetailsPeptide: {"description":"Angiotensin-4","featureId":"PRO_0000420663","evidences":[{"source":"PubMed","id":"10969042","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11815627","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Beta-decarboxylated aspartate; in form angiotensin-A","evidences":[{"source":"PubMed","id":"17138938","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3934016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3934016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues317
DetailsDomain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"20927107","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2493678","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-10-15

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