6I2I
Refined 13pf Hela Cell Tubulin microtubule (EML4-NTD decorated)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0000226 | biological_process | microtubule cytoskeleton organization |
A | 0000278 | biological_process | mitotic cell cycle |
A | 0003725 | molecular_function | double-stranded RNA binding |
A | 0003924 | molecular_function | GTPase activity |
A | 0005198 | molecular_function | structural molecule activity |
A | 0005200 | molecular_function | structural constituent of cytoskeleton |
A | 0005515 | molecular_function | protein binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005856 | cellular_component | cytoskeleton |
A | 0005874 | cellular_component | microtubule |
A | 0005881 | cellular_component | cytoplasmic microtubule |
A | 0005929 | cellular_component | cilium |
A | 0007017 | biological_process | microtubule-based process |
A | 0015630 | cellular_component | microtubule cytoskeleton |
A | 0016787 | molecular_function | hydrolase activity |
A | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0051301 | biological_process | cell division |
A | 0071353 | biological_process | cellular response to interleukin-4 |
B | 0000166 | molecular_function | nucleotide binding |
B | 0000226 | biological_process | microtubule cytoskeleton organization |
B | 0000278 | biological_process | mitotic cell cycle |
B | 0003924 | molecular_function | GTPase activity |
B | 0005198 | molecular_function | structural molecule activity |
B | 0005200 | molecular_function | structural constituent of cytoskeleton |
B | 0005515 | molecular_function | protein binding |
B | 0005525 | molecular_function | GTP binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005634 | cellular_component | nucleus |
B | 0005641 | cellular_component | nuclear envelope lumen |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005856 | cellular_component | cytoskeleton |
B | 0005874 | cellular_component | microtubule |
B | 0007017 | biological_process | microtubule-based process |
B | 0015630 | cellular_component | microtubule cytoskeleton |
B | 0019904 | molecular_function | protein domain specific binding |
B | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
B | 0031625 | molecular_function | ubiquitin protein ligase binding |
B | 0032794 | molecular_function | GTPase activating protein binding |
B | 0032991 | cellular_component | protein-containing complex |
B | 0035578 | cellular_component | azurophil granule lumen |
B | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
B | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
B | 0042288 | molecular_function | MHC class I protein binding |
B | 0044297 | cellular_component | cell body |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0045121 | cellular_component | membrane raft |
B | 0045171 | cellular_component | intercellular bridge |
B | 0046872 | molecular_function | metal ion binding |
B | 0050807 | biological_process | regulation of synapse organization |
B | 0051225 | biological_process | spindle assembly |
B | 0051301 | biological_process | cell division |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071895 | biological_process | odontoblast differentiation |
B | 0072686 | cellular_component | mitotic spindle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue GTP A 501 |
Chain | Residue |
A | GLY10 |
A | THR145 |
A | GLY146 |
A | THR179 |
A | GLU183 |
A | ASN206 |
A | TYR224 |
A | LEU227 |
A | ASN228 |
A | MG502 |
A | GLN11 |
A | ALA12 |
A | GLN15 |
A | ASP98 |
A | ALA100 |
A | ASN101 |
A | GLY143 |
A | GLY144 |
site_id | AC2 |
Number of Residues | 2 |
Details | binding site for residue MG A 502 |
Chain | Residue |
A | THR145 |
A | GTP501 |
site_id | AC3 |
Number of Residues | 16 |
Details | binding site for residue G2P B 501 |
Chain | Residue |
A | GLU254 |
B | GLY10 |
B | GLN11 |
B | CYS12 |
B | GLN15 |
B | ALA99 |
B | ASN101 |
B | SER140 |
B | GLY143 |
B | GLY144 |
B | THR145 |
B | GLY146 |
B | ASN206 |
B | TYR224 |
B | ASN228 |
B | MG502 |
site_id | AC4 |
Number of Residues | 1 |
Details | binding site for residue MG B 502 |
Chain | Residue |
B | G2P501 |
site_id | AC5 |
Number of Residues | 15 |
Details | binding site for residue TA1 B 503 |
Chain | Residue |
B | VAL23 |
B | ASP26 |
B | GLU27 |
B | HIS229 |
B | LEU230 |
B | ALA233 |
B | SER236 |
B | PRO274 |
B | LEU275 |
B | THR276 |
B | GLN281 |
B | PRO360 |
B | ARG369 |
B | GLY370 |
B | LEU371 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | Motif: {"description":"MREC motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | Active site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 9 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 5 |
Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 3 |
Details | Motif: {"description":"MREI motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 7 |
Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI14 |
Number of Residues | 3 |
Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"16371510","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI17 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Campbell A.","Ozanne B.W.","Lourenco F.","Olson M.F."]}}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"} |
Chain | Residue | Details |