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6H0B

Crystal structure of the human GalNAc-T4 in complex with UDP, manganese and the diglycopeptide 6.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0004653molecular_functionpolypeptide N-acetylgalactosaminyltransferase activity
A0005515molecular_functionprotein binding
A0005794cellular_componentGolgi apparatus
A0006486biological_processprotein glycosylation
A0006493biological_processprotein O-linked glycosylation
A0016020cellular_componentmembrane
A0016266biological_processO-glycan processing
A0016757molecular_functionglycosyltransferase activity
A0018242biological_processprotein O-linked glycosylation via serine
A0018243biological_processprotein O-linked glycosylation via threonine
A0030145molecular_functionmanganese ion binding
A0030246molecular_functioncarbohydrate binding
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0070062cellular_componentextracellular exosome
B0000139cellular_componentGolgi membrane
B0004653molecular_functionpolypeptide N-acetylgalactosaminyltransferase activity
B0005515molecular_functionprotein binding
B0005794cellular_componentGolgi apparatus
B0006486biological_processprotein glycosylation
B0006493biological_processprotein O-linked glycosylation
B0016020cellular_componentmembrane
B0016266biological_processO-glycan processing
B0016757molecular_functionglycosyltransferase activity
B0018242biological_processprotein O-linked glycosylation via serine
B0018243biological_processprotein O-linked glycosylation via threonine
B0030145molecular_functionmanganese ion binding
B0030246molecular_functioncarbohydrate binding
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0070062cellular_componentextracellular exosome
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-CYS12
BMET1-CYS12

site_idSWS_FT_FI2
Number of Residues44
DetailsTRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255
ChainResidueDetails
ALEU13-SER35
BLEU13-SER35

site_idSWS_FT_FI3
Number of Residues1084
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
AALA36-LYS578
BALA36-LYS578

site_idSWS_FT_FI4
Number of Residues14
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q10471
ChainResidueDetails
AASP175
BASP227
BHIS229
BTRP334
BHIS362
BTYR370
AARG204
AASP227
AHIS229
ATRP334
AHIS362
ATYR370
BASP175
BARG204

site_idSWS_FT_FI5
Number of Residues6
DetailsSITE: Interaction with glycopeptide substrate => ECO:0000269|PubMed:29208955
ChainResidueDetails
AASP459
AHIS478
AASN483
BASP459
BHIS478
BASN483

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN471
BASN471

222036

PDB entries from 2024-07-03

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