6H03

OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001664	molecular_function	G protein-coupled receptor binding
A	0002376	biological_process	immune system process
A	0002682	biological_process	regulation of immune system process
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005579	cellular_component	membrane attack complex
A	0005615	cellular_component	extracellular space
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0006957	biological_process	complement activation, alternative pathway
A	0006958	biological_process	complement activation, classical pathway
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008009	molecular_function	chemokine activity
A	0010575	biological_process	positive regulation of vascular endothelial growth factor production
A	0010760	biological_process	negative regulation of macrophage chemotaxis
A	0016477	biological_process	cell migration
A	0031640	biological_process	killing of cells of another organism
A	0032722	biological_process	positive regulation of chemokine production
A	0044218	cellular_component	other organism cell membrane
A	0045087	biological_process	innate immune response
A	0050920	biological_process	regulation of chemotaxis
A	0060326	biological_process	cell chemotaxis
A	0070062	cellular_component	extracellular exosome
A	0160257	biological_process	complement activation, GZMK pathway
B	0001970	biological_process	positive regulation of activation of membrane attack complex
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005579	cellular_component	membrane attack complex
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006955	biological_process	immune response
B	0006956	biological_process	complement activation
B	0006958	biological_process	complement activation, classical pathway
B	0022829	molecular_function	wide pore channel activity
B	0031640	biological_process	killing of cells of another organism
B	0044218	cellular_component	other organism cell membrane
B	0045087	biological_process	innate immune response
B	0045766	biological_process	positive regulation of angiogenesis
B	0045917	biological_process	positive regulation of complement activation
B	0050778	biological_process	positive regulation of immune response
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0160257	biological_process	complement activation, GZMK pathway
C	0002376	biological_process	immune system process
C	0005576	cellular_component	extracellular region
C	0005579	cellular_component	membrane attack complex
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0006956	biological_process	complement activation
C	0006957	biological_process	complement activation, alternative pathway
C	0006958	biological_process	complement activation, classical pathway
C	0016020	cellular_component	membrane
C	0022829	molecular_function	wide pore channel activity
C	0031640	biological_process	killing of cells of another organism
C	0044218	cellular_component	other organism cell membrane
C	0044877	molecular_function	protein-containing complex binding
C	0045087	biological_process	innate immune response
C	0050778	biological_process	positive regulation of immune response
C	0055085	biological_process	transmembrane transport
C	0070062	cellular_component	extracellular exosome
C	0160257	biological_process	complement activation, GZMK pathway
C	1903561	cellular_component	extracellular vesicle
D	0002376	biological_process	immune system process
D	0005576	cellular_component	extracellular region
D	0005579	cellular_component	membrane attack complex
D	0005615	cellular_component	extracellular space
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0006956	biological_process	complement activation
D	0006957	biological_process	complement activation, alternative pathway
D	0006958	biological_process	complement activation, classical pathway
D	0022829	molecular_function	wide pore channel activity
D	0031640	biological_process	killing of cells of another organism
D	0044218	cellular_component	other organism cell membrane
D	0045087	biological_process	innate immune response
D	0050778	biological_process	positive regulation of immune response
D	0055085	biological_process	transmembrane transport
D	0070062	cellular_component	extracellular exosome
D	0160257	biological_process	complement activation, GZMK pathway
E	0002376	biological_process	immune system process
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005579	cellular_component	membrane attack complex
E	0005886	cellular_component	plasma membrane
E	0006956	biological_process	complement activation
E	0006957	biological_process	complement activation, alternative pathway
E	0006958	biological_process	complement activation, classical pathway
E	0019841	molecular_function	retinol binding
E	0022829	molecular_function	wide pore channel activity
E	0031640	biological_process	killing of cells of another organism
E	0044218	cellular_component	other organism cell membrane
E	0045087	biological_process	innate immune response
E	0050778	biological_process	positive regulation of immune response
E	0055085	biological_process	transmembrane transport
E	0070062	cellular_component	extracellular exosome
E	0072562	cellular_component	blood microparticle
E	0160257	biological_process	complement activation, GZMK pathway
F	0001848	molecular_function	complement binding
F	0002376	biological_process	immune system process
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005579	cellular_component	membrane attack complex
F	0005615	cellular_component	extracellular space
F	0005886	cellular_component	plasma membrane
F	0006955	biological_process	immune response
F	0006956	biological_process	complement activation
F	0006957	biological_process	complement activation, alternative pathway
F	0006958	biological_process	complement activation, classical pathway
F	0016020	cellular_component	membrane
F	0022829	molecular_function	wide pore channel activity
F	0031640	biological_process	killing of cells of another organism
F	0044218	cellular_component	other organism cell membrane
F	0044877	molecular_function	protein-containing complex binding
F	0045087	biological_process	innate immune response
F	0050778	biological_process	positive regulation of immune response
F	0055085	biological_process	transmembrane transport
F	0070062	cellular_component	extracellular exosome
F	0072562	cellular_component	blood microparticle
F	0160257	biological_process	complement activation, GZMK pathway
G	0001906	biological_process	cell killing
G	0002376	biological_process	immune system process
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005579	cellular_component	membrane attack complex
G	0005615	cellular_component	extracellular space
G	0005886	cellular_component	plasma membrane
G	0006955	biological_process	immune response
G	0006956	biological_process	complement activation
G	0006957	biological_process	complement activation, alternative pathway
G	0006958	biological_process	complement activation, classical pathway
G	0022829	molecular_function	wide pore channel activity
G	0031640	biological_process	killing of cells of another organism
G	0044218	cellular_component	other organism cell membrane
G	0045087	biological_process	innate immune response
G	0050778	biological_process	positive regulation of immune response
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport
G	0070062	cellular_component	extracellular exosome
G	0072562	cellular_component	blood microparticle
G	0160257	biological_process	complement activation, GZMK pathway
H	0001906	biological_process	cell killing
H	0002376	biological_process	immune system process
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005579	cellular_component	membrane attack complex
H	0005615	cellular_component	extracellular space
H	0005886	cellular_component	plasma membrane
H	0006955	biological_process	immune response
H	0006956	biological_process	complement activation
H	0006957	biological_process	complement activation, alternative pathway
H	0006958	biological_process	complement activation, classical pathway
H	0022829	molecular_function	wide pore channel activity
H	0031640	biological_process	killing of cells of another organism
H	0044218	cellular_component	other organism cell membrane
H	0045087	biological_process	innate immune response
H	0050778	biological_process	positive regulation of immune response
H	0051260	biological_process	protein homooligomerization
H	0055085	biological_process	transmembrane transport
H	0070062	cellular_component	extracellular exosome
H	0072562	cellular_component	blood microparticle
H	0160257	biological_process	complement activation, GZMK pathway
I	0001906	biological_process	cell killing
I	0002376	biological_process	immune system process
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005579	cellular_component	membrane attack complex
I	0005615	cellular_component	extracellular space
I	0005886	cellular_component	plasma membrane
I	0006955	biological_process	immune response
I	0006956	biological_process	complement activation
I	0006957	biological_process	complement activation, alternative pathway
I	0006958	biological_process	complement activation, classical pathway
I	0022829	molecular_function	wide pore channel activity
I	0031640	biological_process	killing of cells of another organism
I	0044218	cellular_component	other organism cell membrane
I	0045087	biological_process	innate immune response
I	0050778	biological_process	positive regulation of immune response
I	0051260	biological_process	protein homooligomerization
I	0055085	biological_process	transmembrane transport
I	0070062	cellular_component	extracellular exosome
I	0072562	cellular_component	blood microparticle
I	0160257	biological_process	complement activation, GZMK pathway
J	0001906	biological_process	cell killing
J	0002376	biological_process	immune system process
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005579	cellular_component	membrane attack complex
J	0005615	cellular_component	extracellular space
J	0005886	cellular_component	plasma membrane
J	0006955	biological_process	immune response
J	0006956	biological_process	complement activation
J	0006957	biological_process	complement activation, alternative pathway
J	0006958	biological_process	complement activation, classical pathway
J	0022829	molecular_function	wide pore channel activity
J	0031640	biological_process	killing of cells of another organism
J	0044218	cellular_component	other organism cell membrane
J	0045087	biological_process	innate immune response
J	0050778	biological_process	positive regulation of immune response
J	0051260	biological_process	protein homooligomerization
J	0055085	biological_process	transmembrane transport
J	0070062	cellular_component	extracellular exosome
J	0072562	cellular_component	blood microparticle
J	0160257	biological_process	complement activation, GZMK pathway
K	0001906	biological_process	cell killing
K	0002376	biological_process	immune system process
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005579	cellular_component	membrane attack complex
K	0005615	cellular_component	extracellular space
K	0005886	cellular_component	plasma membrane
K	0006955	biological_process	immune response
K	0006956	biological_process	complement activation
K	0006957	biological_process	complement activation, alternative pathway
K	0006958	biological_process	complement activation, classical pathway
K	0022829	molecular_function	wide pore channel activity
K	0031640	biological_process	killing of cells of another organism
K	0044218	cellular_component	other organism cell membrane
K	0045087	biological_process	innate immune response
K	0050778	biological_process	positive regulation of immune response
K	0051260	biological_process	protein homooligomerization
K	0055085	biological_process	transmembrane transport
K	0070062	cellular_component	extracellular exosome
K	0072562	cellular_component	blood microparticle
K	0160257	biological_process	complement activation, GZMK pathway
L	0001906	biological_process	cell killing
L	0002376	biological_process	immune system process
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005579	cellular_component	membrane attack complex
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0006956	biological_process	complement activation
L	0006957	biological_process	complement activation, alternative pathway
L	0006958	biological_process	complement activation, classical pathway
L	0022829	molecular_function	wide pore channel activity
L	0031640	biological_process	killing of cells of another organism
L	0044218	cellular_component	other organism cell membrane
L	0045087	biological_process	innate immune response
L	0050778	biological_process	positive regulation of immune response
L	0051260	biological_process	protein homooligomerization
L	0055085	biological_process	transmembrane transport
L	0070062	cellular_component	extracellular exosome
L	0072562	cellular_component	blood microparticle
L	0160257	biological_process	complement activation, GZMK pathway
M	0001906	biological_process	cell killing
M	0002376	biological_process	immune system process
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005579	cellular_component	membrane attack complex
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0006955	biological_process	immune response
M	0006956	biological_process	complement activation
M	0006957	biological_process	complement activation, alternative pathway
M	0006958	biological_process	complement activation, classical pathway
M	0022829	molecular_function	wide pore channel activity
M	0031640	biological_process	killing of cells of another organism
M	0044218	cellular_component	other organism cell membrane
M	0045087	biological_process	innate immune response
M	0050778	biological_process	positive regulation of immune response
M	0051260	biological_process	protein homooligomerization
M	0055085	biological_process	transmembrane transport
M	0070062	cellular_component	extracellular exosome
M	0072562	cellular_component	blood microparticle
M	0160257	biological_process	complement activation, GZMK pathway
N	0001906	biological_process	cell killing
N	0002376	biological_process	immune system process
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005579	cellular_component	membrane attack complex
N	0005615	cellular_component	extracellular space
N	0005886	cellular_component	plasma membrane
N	0006955	biological_process	immune response
N	0006956	biological_process	complement activation
N	0006957	biological_process	complement activation, alternative pathway
N	0006958	biological_process	complement activation, classical pathway
N	0022829	molecular_function	wide pore channel activity
N	0031640	biological_process	killing of cells of another organism
N	0044218	cellular_component	other organism cell membrane
N	0045087	biological_process	innate immune response
N	0050778	biological_process	positive regulation of immune response
N	0051260	biological_process	protein homooligomerization
N	0055085	biological_process	transmembrane transport
N	0070062	cellular_component	extracellular exosome
N	0072562	cellular_component	blood microparticle
N	0160257	biological_process	complement activation, GZMK pathway
O	0001906	biological_process	cell killing
O	0002376	biological_process	immune system process
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005579	cellular_component	membrane attack complex
O	0005615	cellular_component	extracellular space
O	0005886	cellular_component	plasma membrane
O	0006955	biological_process	immune response
O	0006956	biological_process	complement activation
O	0006957	biological_process	complement activation, alternative pathway
O	0006958	biological_process	complement activation, classical pathway
O	0022829	molecular_function	wide pore channel activity
O	0031640	biological_process	killing of cells of another organism
O	0044218	cellular_component	other organism cell membrane
O	0045087	biological_process	innate immune response
O	0050778	biological_process	positive regulation of immune response
O	0051260	biological_process	protein homooligomerization
O	0055085	biological_process	transmembrane transport
O	0070062	cellular_component	extracellular exosome
O	0072562	cellular_component	blood microparticle
O	0160257	biological_process	complement activation, GZMK pathway
P	0001906	biological_process	cell killing
P	0002376	biological_process	immune system process
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005579	cellular_component	membrane attack complex
P	0005615	cellular_component	extracellular space
P	0005886	cellular_component	plasma membrane
P	0006955	biological_process	immune response
P	0006956	biological_process	complement activation
P	0006957	biological_process	complement activation, alternative pathway
P	0006958	biological_process	complement activation, classical pathway
P	0022829	molecular_function	wide pore channel activity
P	0031640	biological_process	killing of cells of another organism
P	0044218	cellular_component	other organism cell membrane
P	0045087	biological_process	innate immune response
P	0050778	biological_process	positive regulation of immune response
P	0051260	biological_process	protein homooligomerization
P	0055085	biological_process	transmembrane transport
P	0070062	cellular_component	extracellular exosome
P	0072562	cellular_component	blood microparticle
P	0160257	biological_process	complement activation, GZMK pathway
Q	0001906	biological_process	cell killing
Q	0002376	biological_process	immune system process
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005579	cellular_component	membrane attack complex
Q	0005615	cellular_component	extracellular space
Q	0005886	cellular_component	plasma membrane
Q	0006955	biological_process	immune response
Q	0006956	biological_process	complement activation
Q	0006957	biological_process	complement activation, alternative pathway
Q	0006958	biological_process	complement activation, classical pathway
Q	0022829	molecular_function	wide pore channel activity
Q	0031640	biological_process	killing of cells of another organism
Q	0044218	cellular_component	other organism cell membrane
Q	0045087	biological_process	innate immune response
Q	0050778	biological_process	positive regulation of immune response
Q	0051260	biological_process	protein homooligomerization
Q	0055085	biological_process	transmembrane transport
Q	0070062	cellular_component	extracellular exosome
Q	0072562	cellular_component	blood microparticle
Q	0160257	biological_process	complement activation, GZMK pathway
R	0001906	biological_process	cell killing
R	0002376	biological_process	immune system process
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005579	cellular_component	membrane attack complex
R	0005615	cellular_component	extracellular space
R	0005886	cellular_component	plasma membrane
R	0006955	biological_process	immune response
R	0006956	biological_process	complement activation
R	0006957	biological_process	complement activation, alternative pathway
R	0006958	biological_process	complement activation, classical pathway
R	0022829	molecular_function	wide pore channel activity
R	0031640	biological_process	killing of cells of another organism
R	0044218	cellular_component	other organism cell membrane
R	0045087	biological_process	innate immune response
R	0050778	biological_process	positive regulation of immune response
R	0051260	biological_process	protein homooligomerization
R	0055085	biological_process	transmembrane transport
R	0070062	cellular_component	extracellular exosome
R	0072562	cellular_component	blood microparticle
R	0160257	biological_process	complement activation, GZMK pathway
S	0001906	biological_process	cell killing
S	0002376	biological_process	immune system process
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005579	cellular_component	membrane attack complex
S	0005615	cellular_component	extracellular space
S	0005886	cellular_component	plasma membrane
S	0006955	biological_process	immune response
S	0006956	biological_process	complement activation
S	0006957	biological_process	complement activation, alternative pathway
S	0006958	biological_process	complement activation, classical pathway
S	0022829	molecular_function	wide pore channel activity
S	0031640	biological_process	killing of cells of another organism
S	0044218	cellular_component	other organism cell membrane
S	0045087	biological_process	innate immune response
S	0050778	biological_process	positive regulation of immune response
S	0051260	biological_process	protein homooligomerization
S	0055085	biological_process	transmembrane transport
S	0070062	cellular_component	extracellular exosome
S	0072562	cellular_component	blood microparticle
S	0160257	biological_process	complement activation, GZMK pathway
T	0001906	biological_process	cell killing
T	0002376	biological_process	immune system process
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005579	cellular_component	membrane attack complex
T	0005615	cellular_component	extracellular space
T	0005886	cellular_component	plasma membrane
T	0006955	biological_process	immune response
T	0006956	biological_process	complement activation
T	0006957	biological_process	complement activation, alternative pathway
T	0006958	biological_process	complement activation, classical pathway
T	0022829	molecular_function	wide pore channel activity
T	0031640	biological_process	killing of cells of another organism
T	0044218	cellular_component	other organism cell membrane
T	0045087	biological_process	innate immune response
T	0050778	biological_process	positive regulation of immune response
T	0051260	biological_process	protein homooligomerization
T	0055085	biological_process	transmembrane transport
T	0070062	cellular_component	extracellular exosome
T	0072562	cellular_component	blood microparticle
T	0160257	biological_process	complement activation, GZMK pathway
U	0001906	biological_process	cell killing
U	0002376	biological_process	immune system process
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005579	cellular_component	membrane attack complex
U	0005615	cellular_component	extracellular space
U	0005886	cellular_component	plasma membrane
U	0006955	biological_process	immune response
U	0006956	biological_process	complement activation
U	0006957	biological_process	complement activation, alternative pathway
U	0006958	biological_process	complement activation, classical pathway
U	0022829	molecular_function	wide pore channel activity
U	0031640	biological_process	killing of cells of another organism
U	0044218	cellular_component	other organism cell membrane
U	0045087	biological_process	innate immune response
U	0050778	biological_process	positive regulation of immune response
U	0051260	biological_process	protein homooligomerization
U	0055085	biological_process	transmembrane transport
U	0070062	cellular_component	extracellular exosome
U	0072562	cellular_component	blood microparticle
U	0160257	biological_process	complement activation, GZMK pathway
V	0001906	biological_process	cell killing
V	0002376	biological_process	immune system process
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005579	cellular_component	membrane attack complex
V	0005615	cellular_component	extracellular space
V	0005886	cellular_component	plasma membrane
V	0006955	biological_process	immune response
V	0006956	biological_process	complement activation
V	0006957	biological_process	complement activation, alternative pathway
V	0006958	biological_process	complement activation, classical pathway
V	0022829	molecular_function	wide pore channel activity
V	0031640	biological_process	killing of cells of another organism
V	0044218	cellular_component	other organism cell membrane
V	0045087	biological_process	innate immune response
V	0050778	biological_process	positive regulation of immune response
V	0051260	biological_process	protein homooligomerization
V	0055085	biological_process	transmembrane transport
V	0070062	cellular_component	extracellular exosome
V	0072562	cellular_component	blood microparticle
V	0160257	biological_process	complement activation, GZMK pathway
W	0001906	biological_process	cell killing
W	0002376	biological_process	immune system process
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005579	cellular_component	membrane attack complex
W	0005615	cellular_component	extracellular space
W	0005886	cellular_component	plasma membrane
W	0006955	biological_process	immune response
W	0006956	biological_process	complement activation
W	0006957	biological_process	complement activation, alternative pathway
W	0006958	biological_process	complement activation, classical pathway
W	0022829	molecular_function	wide pore channel activity
W	0031640	biological_process	killing of cells of another organism
W	0044218	cellular_component	other organism cell membrane
W	0045087	biological_process	innate immune response
W	0050778	biological_process	positive regulation of immune response
W	0051260	biological_process	protein homooligomerization
W	0055085	biological_process	transmembrane transport
W	0070062	cellular_component	extracellular exosome
W	0072562	cellular_component	blood microparticle
W	0160257	biological_process	complement activation, GZMK pathway
X	0001906	biological_process	cell killing
X	0002376	biological_process	immune system process
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005579	cellular_component	membrane attack complex
X	0005615	cellular_component	extracellular space
X	0005886	cellular_component	plasma membrane
X	0006955	biological_process	immune response
X	0006956	biological_process	complement activation
X	0006957	biological_process	complement activation, alternative pathway
X	0006958	biological_process	complement activation, classical pathway
X	0022829	molecular_function	wide pore channel activity
X	0031640	biological_process	killing of cells of another organism
X	0044218	cellular_component	other organism cell membrane
X	0045087	biological_process	innate immune response
X	0050778	biological_process	positive regulation of immune response
X	0051260	biological_process	protein homooligomerization
X	0055085	biological_process	transmembrane transport
X	0070062	cellular_component	extracellular exosome
X	0072562	cellular_component	blood microparticle
X	0160257	biological_process	complement activation, GZMK pathway

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	14
Details	LIPOCALIN Lipocalin signature. NFDaqQFAGTWLLV

Chain	Residue	Details
E	ASN21-VAL34

---

site_id	PS00279
Number of Residues	12
Details	MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YrrlidqYGTHY

Chain	Residue	Details
D	TYR292-TYR303
G	TYR314-TYR325
F	TYR300-TYR311
C	TYR279-TYR290
B	TYR354-TYR365

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. ChCkpYtfGAaC

Chain	Residue	Details
D	CYS475-CYS486
G	CYS507-CYS518
F	CYS487-CYS498
C	CYS469-CYS480
B	CYS541-CYS552

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CvCkmPYecgpsldvC

Chain	Residue	Details
D	CYS713-CYS728
G	CYS505-CYS518

---

site_id	PS01209
Number of Residues	24
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIskslv.CNgdsDCdedsADEdr...C

Chain	Residue	Details
D	CYS96-CYS119
G	CYS91-CYS113
F	CYS78-CYS100
C	CYS79-CYS101
B	CYS151-CYS173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Region: {"description":"Involved in the tick complement inhibitor CirpT1","evidences":[{"source":"PubMed","id":"31871188","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18536718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21217642","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KM9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H04","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	163
Details	Domain: {"description":"TSP type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	778
Details	Domain: {"description":"LDL-receptor class A","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	600
Details	Domain: {"description":"EGF-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21454577","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OJY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21454577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	Glycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"10551839","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	49
Details	Domain: {"description":"TSP type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	78
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	12
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	11
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	9
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	26
Details	Glycosylation: {"description":"C-linked (Man) tryptophan; partial","evidences":[{"source":"PubMed","id":"10551839","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	363
Details	Domain: {"description":"MACPF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00745","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Site: {"description":"Not glycosylated"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	61
Details	Domain: {"description":"Sushi 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22500023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E0S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (Fuc...) threonine","evidences":[{"source":"PubMed","id":"22267737","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22267737","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	522
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H04","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	954
Details	Domain: {"description":"TSP type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	18
Details	Site: {"description":"Cleavage; by thrombin","evidences":[{"source":"PubMed","id":"4055801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	18
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	18
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4055801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---