6GR8

Human AURKC INCENP complex bound to BRD-7880

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue F8Z A 401

Chain	Residue
A	LEU49
A	LEU84
A	LEU88
A	GLU91
A	LEU118
A	GLU121
A	ALA123
A	GLU127
A	GLU170
A	LEU173
A	ALA183
A	LYS51
A	ASP184
A	GLY186
A	HOH550
A	GLY52
A	LYS53
A	PHE54
A	VAL57
A	ALA70
A	LYS72
A	ILE79

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArlkeshfi..........VALK

Chain	Residue	Details
A	LEU49-LYS72

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL

Chain	Residue	Details
A	VAL162-LEU174

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895

Chain	Residue	Details
B	THR892

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895

Chain	Residue	Details
B	SEP893
A	LYS72

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by AURKB and AURKC => ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:27332895, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SEP894

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER899

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