6GO5
TdT chimera (Loop1 of pol mu) - Ternary complex with 1-nt gapped DNA substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0006281 | biological_process | DNA repair |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0034061 | molecular_function | DNA polymerase activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0006281 | biological_process | DNA repair |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0034061 | molecular_function | DNA polymerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 601 |
| Chain | Residue |
| A | THR253 |
| A | VAL255 |
| A | VAL258 |
| F | DT5 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | ASP343 |
| A | ASP345 |
| A | XC5603 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue XC5 A 603 |
| Chain | Residue |
| A | ARG336 |
| A | LYS338 |
| A | GLY341 |
| A | HIS342 |
| A | ASP343 |
| A | ASP345 |
| A | TRP451 |
| A | THR452 |
| A | GLY453 |
| A | ARG455 |
| A | MG602 |
| A | HOH734 |
| A | HOH743 |
| F | DG6 |
| H | DG6 |
| A | GLY332 |
| A | GLY333 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 601 |
| Chain | Residue |
| B | ASP343 |
| B | ASP345 |
| B | XC5603 |
| B | HOH756 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 602 |
| Chain | Residue |
| B | THR253 |
| B | VAL255 |
| B | VAL258 |
| B | HOH782 |
| L | DT5 |
| L | HOH102 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue XC5 B 603 |
| Chain | Residue |
| B | GLY332 |
| B | GLY333 |
| B | ARG336 |
| B | LYS338 |
| B | GLY341 |
| B | HIS342 |
| B | ASP343 |
| B | ASP345 |
| B | TRP451 |
| B | THR452 |
| B | GLY453 |
| B | GLU458 |
| B | MG601 |
| B | HOH718 |
| B | HOH760 |
| L | DG6 |
| N | DG6 |
Functional Information from PROSITE/UniProt
| site_id | PS00522 |
| Number of Residues | 20 |
| Details | DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGkmtGhDVDFLItsP |
| Chain | Residue | Details |
| A | GLY332-PRO351 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Involved in DNA binding","evidences":[{"source":"PubMed","id":"11823435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23856622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4I2B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | Region: {"description":"Involved in ssDNA binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Responsible for the low discrimination between dNTP and rNTP","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 632 |
| Chain | Residue | Details |
| A | ASP343 | metal ligand |
| A | ASP345 | metal ligand |
| A | ASP435 | metal ligand, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 632 |
| Chain | Residue | Details |
| B | ASP343 | metal ligand |
| B | ASP345 | metal ligand |
| B | ASP435 | metal ligand, proton acceptor, proton donor |
