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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6GN0

Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form

Functional Information from GO Data
ChainGOidnamespacecontents
A0004860molecular_functionprotein kinase inhibitor activity
A0004864molecular_functionprotein phosphatase inhibitor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005774cellular_componentvacuolar membrane
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0007165biological_processsignal transduction
A0008104biological_processintracellular protein localization
A0016020cellular_componentmembrane
A0017053cellular_componenttranscription repressor complex
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0032991cellular_componentprotein-containing complex
A0042308biological_processnegative regulation of protein import into nucleus
A0042470cellular_componentmelanosome
A0042802molecular_functionidentical protein binding
A0042826molecular_functionhistone deacetylase binding
A0044877molecular_functionprotein-containing complex binding
A0045296molecular_functioncadherin binding
A0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048471cellular_componentperinuclear region of cytoplasm
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0070062cellular_componentextracellular exosome
A0140311molecular_functionprotein sequestering activity
B0004860molecular_functionprotein kinase inhibitor activity
B0004864molecular_functionprotein phosphatase inhibitor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005774cellular_componentvacuolar membrane
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0007165biological_processsignal transduction
B0008104biological_processintracellular protein localization
B0016020cellular_componentmembrane
B0017053cellular_componenttranscription repressor complex
B0019899molecular_functionenzyme binding
B0019904molecular_functionprotein domain specific binding
B0032991cellular_componentprotein-containing complex
B0042308biological_processnegative regulation of protein import into nucleus
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0042826molecular_functionhistone deacetylase binding
B0044877molecular_functionprotein-containing complex binding
B0045296molecular_functioncadherin binding
B0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048471cellular_componentperinuclear region of cytoplasm
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0070062cellular_componentextracellular exosome
B0140311molecular_functionprotein sequestering activity
C0004860molecular_functionprotein kinase inhibitor activity
C0004864molecular_functionprotein phosphatase inhibitor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005774cellular_componentvacuolar membrane
C0005829cellular_componentcytosol
C0005925cellular_componentfocal adhesion
C0007165biological_processsignal transduction
C0008104biological_processintracellular protein localization
C0016020cellular_componentmembrane
C0017053cellular_componenttranscription repressor complex
C0019899molecular_functionenzyme binding
C0019904molecular_functionprotein domain specific binding
C0032991cellular_componentprotein-containing complex
C0042308biological_processnegative regulation of protein import into nucleus
C0042470cellular_componentmelanosome
C0042802molecular_functionidentical protein binding
C0042826molecular_functionhistone deacetylase binding
C0044877molecular_functionprotein-containing complex binding
C0045296molecular_functioncadherin binding
C0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
C0045892biological_processnegative regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048471cellular_componentperinuclear region of cytoplasm
C0050815molecular_functionphosphoserine residue binding
C0051219molecular_functionphosphoprotein binding
C0070062cellular_componentextracellular exosome
C0140311molecular_functionprotein sequestering activity
D0004860molecular_functionprotein kinase inhibitor activity
D0004864molecular_functionprotein phosphatase inhibitor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005774cellular_componentvacuolar membrane
D0005829cellular_componentcytosol
D0005925cellular_componentfocal adhesion
D0007165biological_processsignal transduction
D0008104biological_processintracellular protein localization
D0016020cellular_componentmembrane
D0017053cellular_componenttranscription repressor complex
D0019899molecular_functionenzyme binding
D0019904molecular_functionprotein domain specific binding
D0032991cellular_componentprotein-containing complex
D0042308biological_processnegative regulation of protein import into nucleus
D0042470cellular_componentmelanosome
D0042802molecular_functionidentical protein binding
D0042826molecular_functionhistone deacetylase binding
D0044877molecular_functionprotein-containing complex binding
D0045296molecular_functioncadherin binding
D0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
D0045892biological_processnegative regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048471cellular_componentperinuclear region of cytoplasm
D0050815molecular_functionphosphoserine residue binding
D0051219molecular_functionphosphoprotein binding
D0070062cellular_componentextracellular exosome
D0140311molecular_functionprotein sequestering activity
E0005576cellular_componentextracellular region
F0005576cellular_componentextracellular region
G0005576cellular_componentextracellular region
H0005576cellular_componentextracellular region
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG43-VAL53
site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR213-SER232
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsSite: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CQV8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q9CQV8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68251","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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