6GIV

Structure of GluA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and Rubidium Bromide at 1.75 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GLU A 301

Chain	Residue
A	TYR61
A	TYR220
A	HOH438
A	HOH443
A	HOH509
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 302

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH409
A	HOH414
A	HOH496

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 303

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248
A	HOH498

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 304

Chain	Residue
A	LYS21
A	ARG31
A	LYS52

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL A 305

Chain	Residue
A	ARG148
A	TRP159
A	ARG163

---

site_id	AC6
Number of Residues	3
Details	binding site for residue BR A 306

Chain	Residue
A	HOH467
A	HOH521
A	HOH616

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16483599

Chain	Residue	Details
A	TYR61
A	ARG96
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	PRO89

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	THR91
A	SER142
A	THR143

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

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