6GB7

Structure of H-2Db with scoop loop from tapasin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001913	biological_process	T cell mediated cytotoxicity
A	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0009897	cellular_component	external side of plasma membrane
A	0010977	biological_process	negative regulation of neuron projection development
A	0016020	cellular_component	membrane
A	0019882	biological_process	antigen processing and presentation
A	0030670	cellular_component	phagocytic vesicle membrane
A	0042612	cellular_component	MHC class I protein complex
A	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0030670	cellular_component	phagocytic vesicle membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042612	cellular_component	MHC class I protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
C	0001913	biological_process	T cell mediated cytotoxicity
C	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0009897	cellular_component	external side of plasma membrane
C	0010977	biological_process	negative regulation of neuron projection development
C	0016020	cellular_component	membrane
C	0019882	biological_process	antigen processing and presentation
C	0030670	cellular_component	phagocytic vesicle membrane
C	0042612	cellular_component	MHC class I protein complex
C	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0006968	biological_process	cellular defense response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0010977	biological_process	negative regulation of neuron projection development
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0030670	cellular_component	phagocytic vesicle membrane
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0042026	biological_process	protein refolding
D	0042612	cellular_component	MHC class I protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0051289	biological_process	protein homotetramerization
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006955	biological_process	immune response
E	0009897	cellular_component	external side of plasma membrane
E	0010977	biological_process	negative regulation of neuron projection development
E	0016020	cellular_component	membrane
E	0019882	biological_process	antigen processing and presentation
E	0030670	cellular_component	phagocytic vesicle membrane
E	0042612	cellular_component	MHC class I protein complex
E	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0006968	biological_process	cellular defense response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0010977	biological_process	negative regulation of neuron projection development
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0030670	cellular_component	phagocytic vesicle membrane
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0042026	biological_process	protein refolding
F	0042612	cellular_component	MHC class I protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0051289	biological_process	protein homotetramerization
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0006955	biological_process	immune response
G	0009897	cellular_component	external side of plasma membrane
G	0010977	biological_process	negative regulation of neuron projection development
G	0016020	cellular_component	membrane
G	0019882	biological_process	antigen processing and presentation
G	0030670	cellular_component	phagocytic vesicle membrane
G	0042612	cellular_component	MHC class I protein complex
G	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0006968	biological_process	cellular defense response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0010977	biological_process	negative regulation of neuron projection development
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0030670	cellular_component	phagocytic vesicle membrane
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0042026	biological_process	protein refolding
H	0042612	cellular_component	MHC class I protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0051289	biological_process	protein homotetramerization
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 401

Chain	Residue
A	TRP204
A	ARG234
A	GLN242
B	SER11
B	HIS13
B	PRO14
B	PRO15

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 402

Chain	Residue
A	GLN72
A	GLN65
A	LYS68

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 403

Chain	Residue
A	ARG14
A	PRO15
A	ALA89
A	GLY90
A	HOH566
A	HOH587

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL A 404

Chain	Residue
A	ARG75
A	HOH515

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 405

Chain	Residue
A	ARG6
A	PHE8
A	TYR27
A	ASN30
A	HOH508
A	HOH561
B	HOH208

---

site_id	AC6
Number of Residues	1
Details	binding site for residue GOL B 101

Chain	Residue
B	ARG12

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL B 102

Chain	Residue
A	ASP238
B	ARG12
B	HIS13
B	HOH214
B	HOH245

---

site_id	AC8
Number of Residues	2
Details	binding site for residue GOL B 103

Chain	Residue
B	THR75
B	ASP76

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 C 401

Chain	Residue
C	PRO15
C	ALA89
C	GLY90
C	HOH528
C	HOH532

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL C 402

Chain	Residue
C	ARG35
C	ASP37
C	ALA40
C	ARG44
C	GLU46

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL D 101

Chain	Residue
D	GLN2
D	LYS3
D	THR4
D	HOH201
D	HOH210
D	HOH233

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 F 101

Chain	Residue
F	LYS45
F	PRO47

---

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 G 401

Chain	Residue
G	PRO15
G	ALA89
G	GLY90
G	HOH509
G	HOH519
G	HOH536
G	HOH545

---

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL G 402

Chain	Residue
G	ARG6
G	PHE8
G	TYR27
G	ASN30
H	PHE56
H	TYR63

---

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL G 403

Chain	Residue
G	PRO235
G	HOH524
G	HOH542
H	TYR63
H	LEU65

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263
F	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1136
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLY1-VAL285
C	GLY1-VAL285
E	GLY1-VAL285
G	GLY1-VAL285

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE286-MET307
C	ILE286-MET307
E	ILE286-MET307
G	ILE286-MET307

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LYS308-ALA338
C	LYS308-ALA338
E	LYS308-ALA338
G	LYS308-ALA338

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:P01900

Chain	Residue	Details
A	SER329
C	SER329
E	SER329
G	SER329

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01900

Chain	Residue	Details
A	SER332
C	SER332
E	SER332
G	SER332

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3980466, ECO:0000269|PubMed:7118212

Chain	Residue	Details
A	ASN86
C	ASN86
E	ASN86
G	ASN86

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN176
C	ASN176
E	ASN176
G	ASN176

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3980466

Chain	Residue	Details
A	ASN256
C	ASN256
E	ASN256
G	ASN256

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	CROSSLNK: Glycyl serine ester (Ser-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000305|PubMed:19951915

Chain	Residue	Details
A	SER329
C	SER329
E	SER329
G	SER329

---