6FYX

Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1)

This is a large structure.
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Functional Information from GO Data

ChainGOidnamespacecontents
o0005737cellular_componentcytoplasm
o0010494cellular_componentcytoplasmic stress granule
o0016282cellular_componenteukaryotic 43S preinitiation complex
o0033290cellular_componenteukaryotic 48S preinitiation complex
o0005852cellular_componenteukaryotic translation initiation factor 3 complex
o0071540cellular_componenteukaryotic translation initiation factor 3 complex, eIF3e
o0071541cellular_componenteukaryotic translation initiation factor 3 complex, eIF3m
o0000131cellular_componentincipient cellular bud site
o0043614cellular_componentmulti-eIF complex
o0003729molecular_functionmRNA binding
o0003743molecular_functiontranslation initiation factor activity
o0001732biological_processformation of cytoplasmic translation initiation complex
o0002188biological_processtranslation reinitiation
o0006413biological_processtranslational initiation
p0010494cellular_componentcytoplasmic stress granule
p0016282cellular_componenteukaryotic 43S preinitiation complex
p0033290cellular_componenteukaryotic 48S preinitiation complex
p0005852cellular_componenteukaryotic translation initiation factor 3 complex
p0043614cellular_componentmulti-eIF complex
p0042802molecular_functionidentical protein binding
p0003743molecular_functiontranslation initiation factor activity
p0031369molecular_functiontranslation initiation factor binding
p0002183biological_processcytoplasmic translational initiation
p0001732biological_processformation of cytoplasmic translation initiation complex
p0006413biological_processtranslational initiation
q0005737cellular_componentcytoplasm
q0010494cellular_componentcytoplasmic stress granule
q0016282cellular_componenteukaryotic 43S preinitiation complex
q0033290cellular_componenteukaryotic 48S preinitiation complex
q0005852cellular_componenteukaryotic translation initiation factor 3 complex
q0043614cellular_componentmulti-eIF complex
q0003729molecular_functionmRNA binding
q0003743molecular_functiontranslation initiation factor activity
q0031369molecular_functiontranslation initiation factor binding
q0001732biological_processformation of cytoplasmic translation initiation complex
q0006413biological_processtranslational initiation
r0010494cellular_componentcytoplasmic stress granule
r0016282cellular_componenteukaryotic 43S preinitiation complex
r0033290cellular_componenteukaryotic 48S preinitiation complex
r0005852cellular_componenteukaryotic translation initiation factor 3 complex
r0043614cellular_componentmulti-eIF complex
r0003743molecular_functiontranslation initiation factor activity
r0001732biological_processformation of cytoplasmic translation initiation complex
r0002188biological_processtranslation reinitiation
r0006413biological_processtranslational initiation
r0006415biological_processtranslational termination
s0010494cellular_componentcytoplasmic stress granule
s0016282cellular_componenteukaryotic 43S preinitiation complex
s0033290cellular_componenteukaryotic 48S preinitiation complex
s0005852cellular_componenteukaryotic translation initiation factor 3 complex
s0043614cellular_componentmulti-eIF complex
s0003743molecular_functiontranslation initiation factor activity
s0002183biological_processcytoplasmic translational initiation
s0001732biological_processformation of cytoplasmic translation initiation complex
s0002188biological_processtranslation reinitiation
s0006413biological_processtranslational initiation
i0010494cellular_componentcytoplasmic stress granule
i0016282cellular_componenteukaryotic 43S preinitiation complex
i0033290cellular_componenteukaryotic 48S preinitiation complex
i0003725molecular_functiondouble-stranded RNA binding
i0019901molecular_functionprotein kinase binding
i0043024molecular_functionribosomal small subunit binding
i0003743molecular_functiontranslation initiation factor activity
i0031369molecular_functiontranslation initiation factor binding
i0001732biological_processformation of cytoplasmic translation initiation complex
i0001731biological_processformation of translation preinitiation complex
j0005737cellular_componentcytoplasm
j0010494cellular_componentcytoplasmic stress granule
j0033290cellular_componenteukaryotic 48S preinitiation complex
j0005850cellular_componenteukaryotic translation initiation factor 2 complex
j0005851cellular_componenteukaryotic translation initiation factor 2B complex
j0043614cellular_componentmulti-eIF complex
j0005840cellular_componentribosome
j0043022molecular_functionribosome binding
j0003743molecular_functiontranslation initiation factor activity
j0001731biological_processformation of translation preinitiation complex
j0006413biological_processtranslational initiation
l0016282cellular_componenteukaryotic 43S preinitiation complex
l0005850cellular_componenteukaryotic translation initiation factor 2 complex
l0043614cellular_componentmulti-eIF complex
l0046872molecular_functionmetal ion binding
l0003729molecular_functionmRNA binding
l0003743molecular_functiontranslation initiation factor activity
l0031369molecular_functiontranslation initiation factor binding
l0001732biological_processformation of cytoplasmic translation initiation complex
l0001731biological_processformation of translation preinitiation complex
k0005737cellular_componentcytoplasm
k0005829cellular_componentcytosol
k0016282cellular_componenteukaryotic 43S preinitiation complex
k0033290cellular_componenteukaryotic 48S preinitiation complex
k0005850cellular_componenteukaryotic translation initiation factor 2 complex
k0043614cellular_componentmulti-eIF complex
k0005525molecular_functionGTP binding
k0003924molecular_functionGTPase activity
k0003743molecular_functiontranslation initiation factor activity
k0031369molecular_functiontranslation initiation factor binding
k0001731biological_processformation of translation preinitiation complex
k0045903biological_processpositive regulation of translational fidelity
k0006413biological_processtranslational initiation
m0005829cellular_componentcytosol
m0033290cellular_componenteukaryotic 48S preinitiation complex
m0043614cellular_componentmulti-eIF complex
m0071074molecular_functioneukaryotic initiation factor eIF2 binding
m0005092molecular_functionGDP-dissociation inhibitor activity
m0005525molecular_functionGTP binding
m0003743molecular_functiontranslation initiation factor activity
m0031369molecular_functiontranslation initiation factor binding
m0001732biological_processformation of cytoplasmic translation initiation complex
m0001731biological_processformation of translation preinitiation complex
m0042256biological_processmature ribosome assembly
m0045947biological_processnegative regulation of translational initiation
m0006446biological_processregulation of translational initiation
h0022625cellular_componentcytosolic large ribosomal subunit
h0003735molecular_functionstructural constituent of ribosome
h0002181biological_processcytoplasmic translation
O0005840cellular_componentribosome
O0003735molecular_functionstructural constituent of ribosome
O0006412biological_processtranslation
Q0005840cellular_componentribosome
Q0003735molecular_functionstructural constituent of ribosome
Q0006412biological_processtranslation
V0005737cellular_componentcytoplasm
V0005840cellular_componentribosome
V0003735molecular_functionstructural constituent of ribosome
V0006364biological_processrRNA processing
V0006412biological_processtranslation
W0005840cellular_componentribosome
W0003735molecular_functionstructural constituent of ribosome
W0006412biological_processtranslation
f0022627cellular_componentcytosolic small ribosomal subunit
f0005634cellular_componentnucleus
f0046872molecular_functionmetal ion binding
f0031386molecular_functionprotein tag
f0003735molecular_functionstructural constituent of ribosome
f0002109biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
f0000028biological_processribosomal small subunit assembly
f0006412biological_processtranslation
c0022627cellular_componentcytosolic small ribosomal subunit
c0003735molecular_functionstructural constituent of ribosome
c1900153biological_processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
c0006407biological_processrRNA export from nucleus
c0006412biological_processtranslation
d0005840cellular_componentribosome
d0003735molecular_functionstructural constituent of ribosome
d0008270molecular_functionzinc ion binding
d0006412biological_processtranslation
B0022627cellular_componentcytosolic small ribosomal subunit
B0003735molecular_functionstructural constituent of ribosome
B0006412biological_processtranslation
G0005840cellular_componentribosome
G0003735molecular_functionstructural constituent of ribosome
G0006412biological_processtranslation
A0022627cellular_componentcytosolic small ribosomal subunit
A0003735molecular_functionstructural constituent of ribosome
A0000028biological_processribosomal small subunit assembly
A0006412biological_processtranslation
U0022627cellular_componentcytosolic small ribosomal subunit
U0003735molecular_functionstructural constituent of ribosome
U0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U0006412biological_processtranslation
a0005840cellular_componentribosome
a0003735molecular_functionstructural constituent of ribosome
a0006412biological_processtranslation
S0005840cellular_componentribosome
S0003723molecular_functionRNA binding
S0003735molecular_functionstructural constituent of ribosome
S0006412biological_processtranslation
J0015935cellular_componentsmall ribosomal subunit
J0019843molecular_functionrRNA binding
J0003735molecular_functionstructural constituent of ribosome
J0006412biological_processtranslation
Z0005840cellular_componentribosome
E0005840cellular_componentribosome
E0019843molecular_functionrRNA binding
E0003735molecular_functionstructural constituent of ribosome
E0006412biological_processtranslation
e0005840cellular_componentribosome
e0003735molecular_functionstructural constituent of ribosome
e0006412biological_processtranslation
H0005840cellular_componentribosome
H0003735molecular_functionstructural constituent of ribosome
H0006412biological_processtranslation
F0022627cellular_componentcytosolic small ribosomal subunit
F0003723molecular_functionRNA binding
F0003735molecular_functionstructural constituent of ribosome
F0006407biological_processrRNA export from nucleus
F0006412biological_processtranslation
T0005840cellular_componentribosome
T0003735molecular_functionstructural constituent of ribosome
T0006412biological_processtranslation
Y0005840cellular_componentribosome
Y0003735molecular_functionstructural constituent of ribosome
Y0006412biological_processtranslation
N0022627cellular_componentcytosolic small ribosomal subunit
N0070181molecular_functionsmall ribosomal subunit rRNA binding
N0003735molecular_functionstructural constituent of ribosome
N0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N0006412biological_processtranslation
g0022627cellular_componentcytosolic small ribosomal subunit
g0001965molecular_functionG-protein alpha-subunit binding
g0005092molecular_functionGDP-dissociation inhibitor activity
g0005080molecular_functionprotein kinase C binding
g0043022molecular_functionribosome binding
g0000747biological_processconjugation with cellular fusion
g0007186biological_processG protein-coupled receptor signaling pathway
g0001403biological_processinvasive growth in response to glucose limitation
g0061157biological_processmRNA destabilization
g1902660biological_processnegative regulation of glucose mediated signaling pathway
g2001125biological_processnegative regulation of translational frameshifting
g0031954biological_processpositive regulation of protein autophosphorylation
g0060733biological_processregulation of eIF2 alpha phosphorylation by amino acid starvation
g0032995biological_processregulation of fungal-type cell wall biogenesis
g0010389biological_processregulation of G2/M transition of mitotic cell cycle
L0005840cellular_componentribosome
L0003735molecular_functionstructural constituent of ribosome
L0006412biological_processtranslation
R0005840cellular_componentribosome
R0003735molecular_functionstructural constituent of ribosome
R0006412biological_processtranslation
X0015935cellular_componentsmall ribosomal subunit
X0003735molecular_functionstructural constituent of ribosome
X0006412biological_processtranslation
C0022627cellular_componentcytosolic small ribosomal subunit
C0032040cellular_componentsmall-subunit processome
C0070181molecular_functionsmall ribosomal subunit rRNA binding
C0003735molecular_functionstructural constituent of ribosome
C0045903biological_processpositive regulation of translational fidelity
C0006407biological_processrRNA export from nucleus
C0006412biological_processtranslation
b0005840cellular_componentribosome
b0046872molecular_functionmetal ion binding
b0003735molecular_functionstructural constituent of ribosome
b0006412biological_processtranslation
P0015935cellular_componentsmall ribosomal subunit
P0003723molecular_functionRNA binding
P0003735molecular_functionstructural constituent of ribosome
P0006407biological_processrRNA export from nucleus
P0006412biological_processtranslation
D0022627cellular_componentcytosolic small ribosomal subunit
D0030688cellular_componentpreribosome, small subunit precursor
D0003906molecular_functionDNA-(apurinic or apyrimidinic site) endonuclease activity
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0003723molecular_functionRNA binding
D0003735molecular_functionstructural constituent of ribosome
D0000056biological_processribosomal small subunit export from nucleus
D0006407biological_processrRNA export from nucleus
D0006412biological_processtranslation
I0005840cellular_componentribosome
I0003735molecular_functionstructural constituent of ribosome
I0006412biological_processtranslation
M0022627cellular_componentcytosolic small ribosomal subunit
M0003735molecular_functionstructural constituent of ribosome
M0006412biological_processtranslation
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC11binding site for residue MG 2 1801
ChainResidue
2G361

AC22binding site for residue MG 2 1802
ChainResidue
2G95
2G402

AC33binding site for residue MG 2 1803
ChainResidue
2G551
2A554
2A555

AC41binding site for residue MG 2 1804
ChainResidue
2A100

AC51binding site for residue MG 2 1805
ChainResidue
2A1024

AC62binding site for residue MG 2 1807
ChainResidue
2C49
2A424

AC72binding site for residue MG 2 1809
ChainResidue
2G1329
2C1418

AC81binding site for residue MG 2 1810
ChainResidue
2G10

AC91binding site for residue MG 2 1811
ChainResidue
2A928

AD14binding site for residue MG 2 1812
ChainResidue
2A1761
2G1765
2G1766
2U1769

AD21binding site for residue MG 2 1813
ChainResidue
2G547

AD31binding site for residue MG 2 1814
ChainResidue
2A400

AD41binding site for residue MG 2 1815
ChainResidue
2G16

AD52binding site for residue MG 2 1816
ChainResidue
2A377
2U378

AD61binding site for residue MG 2 1817
ChainResidue
2A28

AD73binding site for residue MG 2 1818
ChainResidue
2G370
2A604
2G606

AD82binding site for residue MG 2 1819
ChainResidue
2G996
2U1003

AD91binding site for residue MG 2 1820
ChainResidue
2C426

AE13binding site for residue MG 2 1821
ChainResidue
2A43
2U44
2A47

AE24binding site for residue MG 2 1822
ChainResidue
2U1759
2A1760
2A1761
2G1766

AE33binding site for residue MG 2 1823
ChainResidue
2A618
2A619
2A620

AE41binding site for residue MG 2 1824
ChainResidue
2G561

AE51binding site for residue MG 2 1825
ChainResidue
2A618

AE62binding site for residue MG 2 1826
ChainResidue
2G1327
2G1329

AE71binding site for residue MG 2 1827
ChainResidue
2A622

AE84binding site for residue MG 2 1828
ChainResidue
2A100
2U101
2U102
2C360

AE91binding site for residue MG 2 1829
ChainResidue
2G20

AF12binding site for residue MG 2 1830
ChainResidue
2G1111
2A1112

AF21binding site for residue MG 2 1831
ChainResidue
2U1768

AF31binding site for residue MG 2 1832
ChainResidue
2G95

AF42binding site for residue MG 2 1833
ChainResidue
2G1724
2G1725

AF54binding site for residue MG 2 1834
ChainResidue
2G1627
2U1628
2G1791
2A1792

AF62binding site for residue MG 2 1835
ChainResidue
2A62
2U82

AF71binding site for residue MG 2 1836
ChainResidue
2G1647

AF82binding site for residue MG 2 1837
ChainResidue
2A459
2G460

AF91binding site for residue MG 2 1838
ChainResidue
2G466

AG14binding site for residue MG 2 1839
ChainResidue
2A622
2G623
2C624
2U1030

AG22binding site for residue MG 2 1840
ChainResidue
2G984
2G1013

AG31binding site for residue MG 2 1843
ChainResidue
2U357

AG42binding site for residue MG 2 1844
ChainResidue
2G1046
BGLN157

AG53binding site for residue MG 2 1846
ChainResidue
2G403
GARG88
GGLU91

AG61binding site for residue MG 2 1847
ChainResidue
2U1302

AG72binding site for residue MG 2 1848
ChainResidue
2A978
2U1014

AG83binding site for residue MG 2 1849
ChainResidue
2U58
2U88
2G89

AG92binding site for residue MG 2 1850
ChainResidue
2A760
2G761

AH13binding site for residue MG 2 1851
ChainResidue
2U8
2A1138
2G1139

AH21binding site for residue MG 2 1852
ChainResidue
2C826

AH32binding site for residue MG 2 1853
ChainResidue
2A514
2C530

AH41binding site for residue MG 2 1854
ChainResidue
2MG1855

AH53binding site for residue MG 2 1855
ChainResidue
2G1293
2G1294
2MG1854

AH61binding site for residue MG 2 1856
ChainResidue
2G937

AH71binding site for residue MG 2 1857
ChainResidue
2U988

AH82binding site for residue MG 2 1858
ChainResidue
2A212
2G213

AH94binding site for residue MG 2 1859
ChainResidue
2G1538
2G1539
2G1540
TGLU44

AI12binding site for residue MG 2 1863
ChainResidue
2G990
2G1010

AI24binding site for residue MG 2 1864
ChainResidue
2U1116
2G1117
2C1127
2U1128

AI32binding site for residue MG 2 1865
ChainResidue
2C1161
2G1163

AI41binding site for residue MG 2 1866
ChainResidue
2G924

AI52binding site for residue MG 2 1868
ChainResidue
2C1158
2U1282

AI62binding site for residue MG 2 1869
ChainResidue
2A1467
2G1539

AI71binding site for residue MG 2 1871
ChainResidue
2C1455

AI83binding site for residue MG 2 1872
ChainResidue
2G1199
2G1200
2A1598

AI93binding site for residue MG 2 1874
ChainResidue
2A1195
2C1196
2C1463

AJ14binding site for residue MG 2 1875
ChainResidue
2G1267
2U1268
2U1432
2G1433

AJ23binding site for residue MG 2 1876
ChainResidue
2G1272
2C1273
22MG1426

AJ33binding site for residue MG 2 1877
ChainResidue
2G1537
2G1538
2G1539

AJ43binding site for residue MG 2 1878
ChainResidue
2A1481
2G1482
2U1520

AJ54binding site for residue MG 2 1879
ChainResidue
2C1273
22MG1426
2G1427
iARG13

AJ63binding site for residue MG 2 1880
ChainResidue
2A1201
2A1202
2C1597

AJ73binding site for residue MG 2 1882
ChainResidue
2A629
2G630
2C968

AJ82binding site for residue MG 2 1883
ChainResidue
2U1184
2C1455

AJ94binding site for residue MG 2 1884
ChainResidue
2C1158
2A1159
2U1577
QTYR142

AK12binding site for residue MG 2 1885
ChainResidue
2G1169
2C1461

AK22binding site for residue MG 2 1886
ChainResidue
2G1168
2G1169

AK32binding site for residue MG 2 1887
ChainResidue
2G1166
2U1167

AK42binding site for residue MG 2 1888
ChainResidue
2A1467
2C1587

AK54binding site for residue MG 2 1890
ChainResidue
2C1479
2A1522
2A1523
TLEU79

AK61binding site for residue MG 2 1891
ChainResidue
2U1767

AK73binding site for residue MG 2 1892
ChainResidue
2G1766
2U1767
3A27

AK82binding site for residue MG 2 1893
ChainResidue
2G1758
mASN30

AK94binding site for residue MG 2 1897
ChainResidue
2U1793
2A1795
aGLY9
aLYS34

AL14binding site for residue MG 2 1898
ChainResidue
2C565
XGLU60
XILE68
iARG62

AL21binding site for residue MG 2 1899
ChainResidue
2A1631

AL31binding site for residue MG 2 1900
ChainResidue
2C423

AL44binding site for residue MG 2 1901
ChainResidue
2G91
2G395
2A396
2G397

AL52binding site for residue MG 2 1902
ChainResidue
2C249
2A250

AL61binding site for residue MG 2 1903
ChainResidue
2C401

AL72binding site for residue MG 2 1904
ChainResidue
2A543
2A544

AL82binding site for residue MG 2 1905
ChainResidue
2A634
2A635

AL92binding site for residue MG 2 1906
ChainResidue
2A756
2A792

AM12binding site for residue MG 2 1907
ChainResidue
2A861
2A862

AM25binding site for residue MG 2 1908
ChainResidue
2G894
2U895
2G913
2A914
2U916

AM32binding site for residue MG 2 1909
ChainResidue
2A969
2A970

AM42binding site for residue MG 2 1910
ChainResidue
2G1108
2G1109

AM51binding site for residue MG 2 1911
ChainResidue
2C1204

AM64binding site for residue MG 2 1912
ChainResidue
2A1203
2C1204
2U1205
2G1453

AM72binding site for residue MG 2 1913
ChainResidue
2U1376
2C1377

AM82binding site for residue MG 2 1914
ChainResidue
2G1446
2U1447

AM92binding site for residue MG 2 1915
ChainResidue
2C1157
2G1614

AN12binding site for residue MG 2 1916
ChainResidue
2C1283
2A1420

AN24binding site for residue ZN a 500
ChainResidue
aCYS23
aCYS26
aCYS74
aCYS77

AN34binding site for residue ZN b 101
ChainResidue
bCYS56
bCYS59
bTHR61
bVAL62

AN45binding site for residue ZN f 501
ChainResidue
fCYS121
fCYS124
fCYS139
fLYS141
fCYS142

AN57binding site for residue MET k 601
ChainResidue
1A76
kTYR142
kASN144
kPHE381
kALA382
kGLU383
kLEU395

AN63binding site for residue MG k 602
ChainResidue
kSER114
kTHR137
kASP193

AN717binding site for residue GCP k 603
ChainResidue
kHIS108
kVAL109
kHIS111
kGLY112
kLYS113
kSER114
kTHR115
kARG127
kASN135
kILE136
kGLY196
kASN249
kLYS250
kALA285
kGLN286
lTHR238
lSER264

AN83binding site for residue ZN l 301
ChainResidue
lCYS236
lTHR238
lSER264

AN94binding site for residue ZN m 501
ChainResidue
mCYS99
mCYS121
mLYS126
mTHR128

AO110binding site for residues 1MG 1 9 and 2MG 1 10
ChainResidue
1U8
1C11
1A21
1G22
1C23
1C25
1M2G26
1U45
17MG46
1H2U47

AO25binding site for residues 7MG 1 46 and H2U 1 47
ChainResidue
11MG9
1A21
1U45
15MC48
1U50

AO311binding site for residues H2U 1 47 and 5MC 1 48
ChainResidue
1G7
1U8
11MG9
1A14
1G15
1A21
1G22
17MG46
15MC49
1U50
1A59

AO413binding site for residues 5MC 1 48 and 5MC 1 49
ChainResidue
1G7
1U8
1A14
1G15
1A21
1G22
17MG46
1H2U47
1U50
1A59
1RIA64
1G65
1C66

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
5MC_6fyx_1_4885-METHYLCYTIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1G7-U85MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
1A14-G155MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
1A21-G225MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
1U505MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
1A595MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE

5MC_6fyx_1_4975-METHYLCYTIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1G7-U85MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
1U505MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
1A59-A605MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
1G65-C665MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE

1MG_6fyx_1_981N-METHYLGUANOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1U81MG: 1N-METHYLGUANOSINE-5'-MONOPHOSPHATE
1C11-G121MG: 1N-METHYLGUANOSINE-5'-MONOPHOSPHATE
1A21-G241MG: 1N-METHYLGUANOSINE-5'-MONOPHOSPHATE
1U451MG: 1N-METHYLGUANOSINE-5'-MONOPHOSPHATE

2MG_6fyx_1_1062N-METHYLGUANOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1U82MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
1C112MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
1G24-C252MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
1U452MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
mLYS242MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE

7MG_6fyx_1_4647N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1U87MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
1A21-G227MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
1U457MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE

H2U_6fyx_1_1665,6-DIHYDROURIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1G15H2U: 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE
1G18H2U: 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE
1A59-C61H2U: 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE
jGLN103H2U: 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE

1MA_6fyx_1_5896-HYDRO-1-METHYLADENOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1G18-A201MA: 6-HYDRO-1-METHYLADENOSINE-5'-MONOPHOSPHATE
1A54-U551MA: 6-HYDRO-1-METHYLADENOSINE-5'-MONOPHOSPHATE
1G571MA: 6-HYDRO-1-METHYLADENOSINE-5'-MONOPHOSPHATE
1A59-C611MA: 6-HYDRO-1-METHYLADENOSINE-5'-MONOPHOSPHATE

M2G_6fyx_1_269N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1C25M2G: N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE
1C27M2G: N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE
1G43-U45M2G: N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE
mLYS24-GLU26M2G: N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE
mARG73M2G: N2-DIMETHYLGUANOSINE-5'-MONOPHOSPHATE

7MG_6fyx_2_1573107N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1G29-G307MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
1C41-U427MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
2G1168-G11697MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
2G15727MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
2A1574-A15757MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE
jGLN607MG: 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE

T6A_6fyx_1_3711N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1C32-U33T6A: N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5'-MONOPHOSPHATE
1U36T6A: N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5'-MONOPHOSPHATE
1A38T6A: N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5'-MONOPHOSPHATE
3A27-A29T6A: N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5'-MONOPHOSPHATE
mARG28-GLY31T6A: N-[N-(9-B-D-RIBOFURANOSYLPURIN-6-YL)CARBAMOYL]THREONINE-5'-MONOPHOSPHATE

C4J_6fyx_2_119011(5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol binding site
ChainResidueligand
1C34C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
2C1189C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
2C1191C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
2A1193C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
2G1620C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
2C1635C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
QTYR142-ARG143C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
iASN5C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol
iGLY9-LYS10C4J: (5S)-5-{3-[(3S)-3-amino-3-carboxypropyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl}-2,5-anhydro-1-O-phosphono-L-arabinitol

H2U_6fyx_1_4715,6-DIHYDROURIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1U50H2U: 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE

RIA_6fyx_1_6462'-O-[(5'-PHOSPHO)RIBOSYL]ADENOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
1U50-G53RIA: 2'-O-[(5'-PHOSPHO)RIBOSYL]ADENOSINE-5'-MONOPHOSPHATE
1G63RIA: 2'-O-[(5'-PHOSPHO)RIBOSYL]ADENOSINE-5'-MONOPHOSPHATE
1G65RIA: 2'-O-[(5'-PHOSPHO)RIBOSYL]ADENOSINE-5'-MONOPHOSPHATE

MET_6fyx_k_60112METHIONINE binding site
ChainResidueligand
1A76MET: METHIONINE
kTYR142MET: METHIONINE
kASN144MET: METHIONINE
kARG319MET: METHIONINE
kPHE321MET: METHIONINE
kGLY339MET: METHIONINE
kPHE381-GLU383MET: METHIONINE
kLEU395-GLY397MET: METHIONINE

PSU_6fyx_2_4655PSEUDOURIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2A41PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2A437-U438PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2G464PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2G466PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE

PSU_6fyx_2_1208PSEUDOURIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2U118-A119PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2U121PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2G290PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2U295-C297PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
EALA33PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE

PSU_6fyx_2_7669PSEUDOURIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2U764-G765PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2U767-A771PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2G775-G776PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE

AYA_6fyx_B_212N-ACETYLALANINE binding site
ChainResidueligand
2G898-A899AYA: N-ACETYLALANINE
BVAL3-GLY4AYA: N-ACETYLALANINE
OGLY45-MET46AYA: N-ACETYLALANINE
OVAL48-ASP51AYA: N-ACETYLALANINE
OGLU54AYA: N-ACETYLALANINE
jARG89AYA: N-ACETYLALANINE

5MC_6fyx_2_1006145-METHYLCYTIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2U9025MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
2A904-A9055MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
2G996-A9975MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
2U1003-C10055MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
2G10075MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
OGLY1305MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
OGLY134-LEU1375MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE

PSU_6fyx_2_99813PSEUDOURIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2G903-A904PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2A997PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2C999PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2A1002-C1005PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
3A26-A27PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
jARG53-ARG55PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE

MA6_6fyx_2_1780146N-DIMETHYLADENOSINE-5'-MONOPHOSHATE binding site
ChainResidueligand
2G1001-A1002MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE
2C1639-G1640MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE
2G1758-A1760MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE
2U1777MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE
2A1779MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE
2C1781-C1782MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE
hMET1-ARG2MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE
hARG9MA6: 6N-DIMETHYLADENOSINE-5'-MONOPHOSHATE

2MG_6fyx_2_1570102N-METHYLGUANOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2G11692MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2C1468-A14692MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2G1534-U15362MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2C15692MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2A1571-G15722MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
FARG1872MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE

2MG_6fyx_2_1426122N-METHYLGUANOSINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2C11892MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2G1272-C12732MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2C1278-G12802MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2C1424-A14252MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
2G14272MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
UGLU74-GLY752MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE
iARG132MG: 2N-METHYLGUANOSINE-5'-MONOPHOSPHATE

PSU_6fyx_2_12898PSEUDOURIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2U1288PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2G1290PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2U1304PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2A1324-A1325PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
2U1421PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
CLYS93PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE
CARG100PSU: PSEUDOURIDINE-5'-MONOPHOSPHATE

5MC_6fyx_2_1637105-METHYLCYTIDINE-5'-MONOPHOSPHATE binding site
ChainResidueligand
2A1629-C16325MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
2G16365MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
2C16385MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
2A1761-C17625MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE
3U30-G315MC: 5-METHYLCYTIDINE-5'-MONOPHOSPHATE

GCP_6fyx_k_60330PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER binding site
ChainResidueligand
kHIS108-THR115GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
kARG127GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
kASN135-THR137GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
kASP193-HIS197GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
kASN249-LYS250GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
kASP252-LEU253GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
kSER284-GLN286GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
lCYS236GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
lTHR238-CYS239GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
lSER264-ARG266GCP: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails