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6FY4

Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0003723molecular_functionRNA binding
A0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
A0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006743biological_processubiquinone metabolic process
A0006805biological_processxenobiotic metabolic process
A0006809biological_processnitric oxide biosynthetic process
A0006979biological_processresponse to oxidative stress
A0007271biological_processsynaptic transmission, cholinergic
A0008753molecular_functionNADPH dehydrogenase (quinone) activity
A0009636biological_processresponse to toxic substance
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0030163biological_processprotein catabolic process
A0032496biological_processresponse to lipopolysaccharide
A0034599biological_processcellular response to oxidative stress
A0042177biological_processnegative regulation of protein catabolic process
A0042360biological_processvitamin E metabolic process
A0042373biological_processvitamin K metabolic process
A0042802molecular_functionidentical protein binding
A0045087biological_processinnate immune response
A0045202cellular_componentsynapse
A0045454biological_processcell redox homeostasis
A0050136molecular_functionNADH dehydrogenase (quinone) (non-electrogenic) activity
A0061771biological_processresponse to caloric restriction
A0110076biological_processnegative regulation of ferroptosis
B0000209biological_processprotein polyubiquitination
B0003723molecular_functionRNA binding
B0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
B0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006743biological_processubiquinone metabolic process
B0006805biological_processxenobiotic metabolic process
B0006809biological_processnitric oxide biosynthetic process
B0006979biological_processresponse to oxidative stress
B0007271biological_processsynaptic transmission, cholinergic
B0008753molecular_functionNADPH dehydrogenase (quinone) activity
B0009636biological_processresponse to toxic substance
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0030163biological_processprotein catabolic process
B0032496biological_processresponse to lipopolysaccharide
B0034599biological_processcellular response to oxidative stress
B0042177biological_processnegative regulation of protein catabolic process
B0042360biological_processvitamin E metabolic process
B0042373biological_processvitamin K metabolic process
B0042802molecular_functionidentical protein binding
B0045087biological_processinnate immune response
B0045202cellular_componentsynapse
B0045454biological_processcell redox homeostasis
B0050136molecular_functionNADH dehydrogenase (quinone) (non-electrogenic) activity
B0061771biological_processresponse to caloric restriction
B0110076biological_processnegative regulation of ferroptosis
C0000209biological_processprotein polyubiquitination
C0003723molecular_functionRNA binding
C0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
C0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006743biological_processubiquinone metabolic process
C0006805biological_processxenobiotic metabolic process
C0006809biological_processnitric oxide biosynthetic process
C0006979biological_processresponse to oxidative stress
C0007271biological_processsynaptic transmission, cholinergic
C0008753molecular_functionNADPH dehydrogenase (quinone) activity
C0009636biological_processresponse to toxic substance
C0016491molecular_functionoxidoreductase activity
C0019430biological_processremoval of superoxide radicals
C0030163biological_processprotein catabolic process
C0032496biological_processresponse to lipopolysaccharide
C0034599biological_processcellular response to oxidative stress
C0042177biological_processnegative regulation of protein catabolic process
C0042360biological_processvitamin E metabolic process
C0042373biological_processvitamin K metabolic process
C0042802molecular_functionidentical protein binding
C0045087biological_processinnate immune response
C0045202cellular_componentsynapse
C0045454biological_processcell redox homeostasis
C0050136molecular_functionNADH dehydrogenase (quinone) (non-electrogenic) activity
C0061771biological_processresponse to caloric restriction
C0110076biological_processnegative regulation of ferroptosis
D0000209biological_processprotein polyubiquitination
D0003723molecular_functionRNA binding
D0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
D0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006743biological_processubiquinone metabolic process
D0006805biological_processxenobiotic metabolic process
D0006809biological_processnitric oxide biosynthetic process
D0006979biological_processresponse to oxidative stress
D0007271biological_processsynaptic transmission, cholinergic
D0008753molecular_functionNADPH dehydrogenase (quinone) activity
D0009636biological_processresponse to toxic substance
D0016491molecular_functionoxidoreductase activity
D0019430biological_processremoval of superoxide radicals
D0030163biological_processprotein catabolic process
D0032496biological_processresponse to lipopolysaccharide
D0034599biological_processcellular response to oxidative stress
D0042177biological_processnegative regulation of protein catabolic process
D0042360biological_processvitamin E metabolic process
D0042373biological_processvitamin K metabolic process
D0042802molecular_functionidentical protein binding
D0045087biological_processinnate immune response
D0045202cellular_componentsynapse
D0045454biological_processcell redox homeostasis
D0050136molecular_functionNADH dehydrogenase (quinone) (non-electrogenic) activity
D0061771biological_processresponse to caloric restriction
D0110076biological_processnegative regulation of ferroptosis
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue FAD A 301
ChainResidue
AHIS12
APHE107
ATHR148
ATHR149
AGLY150
AGLY151
ATYR156
AILE193
AARG201
ALEU205
BGLN67
ATHR16
CASP62
CASN65
DARG201
DFAD301
ASER17
APHE18
AASN19
AALA21
ALEU104
AGLN105
ATRP106

site_idAC2
Number of Residues6
Detailsbinding site for residue EAW A 302
ChainResidue
APRO69
ATYR127
ATYR129
BGLY150
BGLY151
BFAD301

site_idAC3
Number of Residues21
Detailsbinding site for residue FAD B 301
ChainResidue
AASN65
ATYR68
APRO69
AEAW302
BHIS12
BTHR16
BSER17
BPHE18
BASN19
BALA21
BLEU104
BGLN105
BTRP106
BPHE107
BTHR148
BTHR149
BGLY150
BGLY151
BTYR156
BILE193
BARG201

site_idAC4
Number of Residues18
Detailsbinding site for residue FAD C 301
ChainResidue
CHIS12
CTHR16
CSER17
CPHE18
CASN19
CALA21
CPRO103
CLEU104
CGLN105
CTRP106
CPHE107
CTHR148
CTHR149
CGLY150
CGLY151
CTYR156
CILE193
CARG201

site_idAC5
Number of Residues25
Detailsbinding site for residue FAD D 301
ChainResidue
AARG201
AFAD301
BASP62
BASN65
CGLN67
CTYR68
DHIS12
DTHR16
DSER17
DPHE18
DASN19
DALA21
DPRO103
DLEU104
DGLN105
DTRP106
DPHE107
DTHR148
DTHR149
DGLY150
DGLY151
DTYR156
DILE193
DARG201
DLEU205

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues44
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10543876","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10706635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11735396","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
AGLY150electrostatic stabiliser, hydrogen bond donor
ATYR156electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
AHIS162hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA2
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
BGLY150electrostatic stabiliser, hydrogen bond donor
BTYR156electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
BHIS162hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA3
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
CGLY150electrostatic stabiliser, hydrogen bond donor
CTYR156electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
CHIS162hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

site_idMCSA4
Number of Residues3
DetailsM-CSA 3
ChainResidueDetails
DGLY150electrostatic stabiliser, hydrogen bond donor
DTYR156electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
DHIS162hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

239803

PDB entries from 2025-08-06

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