6FXT

Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Cocrystal with Fe2+, Mn2+, UDP-Glc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001701	biological_process	in utero embryonic development
A	0001886	biological_process	endothelial cell morphogenesis
A	0003824	molecular_function	catalytic activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005791	cellular_component	rough endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0008104	biological_process	intracellular protein localization
A	0008475	molecular_function	procollagen-lysine 5-dioxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0021915	biological_process	neural tube development
A	0030199	biological_process	collagen fibril organization
A	0031012	cellular_component	extracellular matrix
A	0031418	molecular_function	L-ascorbic acid binding
A	0032963	biological_process	collagen metabolic process
A	0032964	biological_process	collagen biosynthetic process
A	0033823	molecular_function	procollagen glucosyltransferase activity
A	0036094	molecular_function	small molecule binding
A	0042311	biological_process	vasodilation
A	0046872	molecular_function	metal ion binding
A	0046947	biological_process	hydroxylysine biosynthetic process
A	0048730	biological_process	epidermis morphogenesis
A	0050211	molecular_function	procollagen galactosyltransferase activity
A	0051213	molecular_function	dioxygenase activity
A	0060425	biological_process	lung morphogenesis
A	0070062	cellular_component	extracellular exosome
A	0070831	biological_process	basement membrane assembly
A	0180062	biological_process	protein O-linked glycosylation via galactose

Functional Information from PROSITE/UniProt

site_id	PS01325
Number of Residues	8
Details	LYS_HYDROXYLASE Lysyl hydroxylase signature. PHHDSSTF

Chain	Residue	Details
A	PRO666-PHE673

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	91
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	225
Details	Region: {"description":"Accessory region","evidences":[{"source":"PubMed","id":"30089812","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	43
Details	Region: {"description":"Important for dimerization","evidences":[{"source":"PubMed","id":"30089812","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30089812","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6FXY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30089812","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6FXY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30089812","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6FXY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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