6FWH
Acanthamoeba IGPD in complex with R-C348 to 1.7A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000105 | biological_process | L-histidine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000105 | biological_process | L-histidine biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000105 | biological_process | L-histidine biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000105 | biological_process | L-histidine biosynthetic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000105 | biological_process | L-histidine biosynthetic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000105 | biological_process | L-histidine biosynthetic process |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000105 | biological_process | L-histidine biosynthetic process |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0000105 | biological_process | L-histidine biosynthetic process |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| I | 0008652 | biological_process | amino acid biosynthetic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0000105 | biological_process | L-histidine biosynthetic process |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| J | 0008652 | biological_process | amino acid biosynthetic process |
| J | 0016829 | molecular_function | lyase activity |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0000105 | biological_process | L-histidine biosynthetic process |
| K | 0003824 | molecular_function | catalytic activity |
| K | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| K | 0008652 | biological_process | amino acid biosynthetic process |
| K | 0016829 | molecular_function | lyase activity |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0000105 | biological_process | L-histidine biosynthetic process |
| L | 0003824 | molecular_function | catalytic activity |
| L | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| L | 0008652 | biological_process | amino acid biosynthetic process |
| L | 0016829 | molecular_function | lyase activity |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 201 |
| Chain | Residue |
| A | HIS40 |
| A | HIS162 |
| A | GLU166 |
| A | 5LD203 |
| F | HIS67 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 202 |
| Chain | Residue |
| B | 5LD203 |
| B | HOH318 |
| A | HIS66 |
| A | GLU70 |
| A | HIS138 |
| B | HIS163 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue 5LD A 203 |
| Chain | Residue |
| A | HIS40 |
| A | HIS162 |
| A | HIS163 |
| A | GLU166 |
| A | LYS170 |
| A | MN201 |
| A | HOH345 |
| C | ARG92 |
| C | ARG114 |
| C | SER191 |
| C | LYS193 |
| F | GLU14 |
| F | HIS66 |
| F | HIS67 |
| F | GLU70 |
| F | MN201 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 201 |
| Chain | Residue |
| A | HIS67 |
| B | HIS40 |
| B | HIS162 |
| B | GLU166 |
| B | 5LD203 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 202 |
| Chain | Residue |
| B | HIS66 |
| B | GLU70 |
| B | HIS138 |
| B | 5LD204 |
| G | HIS163 |
| G | HOH318 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue 5LD B 203 |
| Chain | Residue |
| A | GLU14 |
| A | HIS66 |
| A | HIS67 |
| A | GLU70 |
| A | MN202 |
| B | HIS40 |
| B | HIS162 |
| B | HIS163 |
| B | GLU166 |
| B | LYS170 |
| B | MN201 |
| B | HOH356 |
| K | ARG92 |
| K | ARG114 |
| K | SER191 |
| K | LYS193 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue 5LD B 204 |
| Chain | Residue |
| B | GLU14 |
| B | HIS66 |
| B | HIS67 |
| B | GLU70 |
| B | MN202 |
| B | HOH319 |
| G | HIS40 |
| G | HIS162 |
| G | HIS163 |
| G | GLU166 |
| G | LYS170 |
| G | MN202 |
| L | ARG92 |
| L | ARG114 |
| L | SER191 |
| L | LYS193 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MN C 201 |
| Chain | Residue |
| C | HIS40 |
| C | HIS162 |
| C | GLU166 |
| C | 5LD204 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue MN C 202 |
| Chain | Residue |
| C | HIS163 |
| C | 5LD204 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MN C 203 |
| Chain | Residue |
| C | HIS66 |
| C | GLU70 |
| C | HIS138 |
| J | HIS163 |
| J | 5LD202 |
| J | HOH321 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue 5LD C 204 |
| Chain | Residue |
| C | HIS40 |
| C | HIS162 |
| C | HIS163 |
| C | GLU166 |
| C | LYS170 |
| C | MN201 |
| C | MN202 |
| C | HOH308 |
| E | ARG92 |
| E | ARG114 |
| E | SER191 |
| E | LYS193 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 201 |
| Chain | Residue |
| D | HIS40 |
| D | HIS162 |
| D | GLU166 |
| D | 5LD202 |
| L | HIS67 |
| site_id | AD4 |
| Number of Residues | 16 |
| Details | binding site for residue 5LD D 202 |
| Chain | Residue |
| B | ARG92 |
| B | ARG114 |
| B | SER191 |
| B | LYS193 |
| D | HIS40 |
| D | HIS162 |
| D | HIS163 |
| D | GLU166 |
| D | LYS170 |
| D | MN201 |
| D | HOH310 |
| L | GLU14 |
| L | HIS66 |
| L | HIS67 |
| L | GLU70 |
| L | MN201 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MN E 201 |
| Chain | Residue |
| E | HIS40 |
| E | HIS162 |
| E | GLU166 |
| E | 5LD202 |
| K | HIS67 |
| site_id | AD6 |
| Number of Residues | 16 |
| Details | binding site for residue 5LD E 202 |
| Chain | Residue |
| A | ARG92 |
| A | ARG114 |
| A | SER191 |
| A | LYS193 |
| E | HIS40 |
| E | HIS162 |
| E | HIS163 |
| E | GLU166 |
| E | LYS170 |
| E | MN201 |
| E | HOH342 |
| K | GLU14 |
| K | HIS66 |
| K | HIS67 |
| K | GLU70 |
| K | MN201 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue MN F 201 |
| Chain | Residue |
| A | HIS163 |
| A | 5LD203 |
| F | HIS66 |
| F | GLU70 |
| F | HIS138 |
| F | HOH317 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MN F 202 |
| Chain | Residue |
| F | HIS40 |
| F | HIS162 |
| F | GLU166 |
| F | 5LD203 |
| G | HIS67 |
| site_id | AD9 |
| Number of Residues | 16 |
| Details | binding site for residue 5LD F 203 |
| Chain | Residue |
| F | HIS40 |
| F | HIS162 |
| F | HIS163 |
| F | GLU166 |
| F | LYS170 |
| F | MN202 |
| F | HOH352 |
| G | GLU14 |
| G | HIS66 |
| G | HIS67 |
| G | GLU70 |
| G | MN201 |
| H | ARG92 |
| H | ARG114 |
| H | SER191 |
| H | LYS193 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MN G 201 |
| Chain | Residue |
| F | HIS163 |
| F | 5LD203 |
| F | HOH321 |
| G | HIS66 |
| G | GLU70 |
| G | HIS138 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue MN G 202 |
| Chain | Residue |
| B | HIS67 |
| B | 5LD204 |
| G | HIS40 |
| G | HIS162 |
| G | GLU166 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue MN H 201 |
| Chain | Residue |
| H | HIS40 |
| H | HIS162 |
| H | GLU166 |
| H | 5LD204 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue MN H 202 |
| Chain | Residue |
| H | HIS163 |
| H | 5LD204 |
| H | HOH347 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue MN H 203 |
| Chain | Residue |
| H | HIS66 |
| H | GLU70 |
| H | HIS138 |
| H | HOH339 |
| I | HIS163 |
| I | 5LD202 |
| site_id | AE6 |
| Number of Residues | 13 |
| Details | binding site for residue 5LD H 204 |
| Chain | Residue |
| H | HIS40 |
| H | HIS162 |
| H | HIS163 |
| H | GLU166 |
| H | LYS170 |
| H | MN201 |
| H | MN202 |
| H | HOH326 |
| H | HOH347 |
| J | ARG92 |
| J | ARG114 |
| J | SER191 |
| J | LYS193 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue MN I 201 |
| Chain | Residue |
| H | HIS67 |
| I | HIS40 |
| I | HIS162 |
| I | GLU166 |
| I | 5LD202 |
| site_id | AE8 |
| Number of Residues | 17 |
| Details | binding site for residue 5LD I 202 |
| Chain | Residue |
| G | ARG92 |
| G | ARG114 |
| G | SER191 |
| G | THR192 |
| G | LYS193 |
| H | GLU14 |
| H | HIS66 |
| H | HIS67 |
| H | GLU70 |
| H | MN203 |
| I | HIS40 |
| I | HIS162 |
| I | HIS163 |
| I | GLU166 |
| I | LYS170 |
| I | MN201 |
| I | HOH364 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue MN J 201 |
| Chain | Residue |
| C | HIS67 |
| J | HIS40 |
| J | HIS162 |
| J | GLU166 |
| J | 5LD202 |
| site_id | AF1 |
| Number of Residues | 17 |
| Details | binding site for residue 5LD J 202 |
| Chain | Residue |
| C | GLU14 |
| C | HIS66 |
| C | HIS67 |
| C | GLU70 |
| C | MN203 |
| F | ARG92 |
| F | ARG114 |
| F | SER191 |
| F | LYS193 |
| J | HIS40 |
| J | HIS162 |
| J | HIS163 |
| J | GLU166 |
| J | LYS170 |
| J | MN201 |
| J | HOH321 |
| J | HOH344 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue MN K 201 |
| Chain | Residue |
| E | HIS163 |
| E | 5LD202 |
| K | HIS66 |
| K | GLU70 |
| K | HIS138 |
| K | HOH321 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue MN K 202 |
| Chain | Residue |
| K | HIS40 |
| K | HIS162 |
| K | GLU166 |
| K | 5LD204 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue MN K 203 |
| Chain | Residue |
| K | HIS163 |
| K | 5LD204 |
| site_id | AF5 |
| Number of Residues | 12 |
| Details | binding site for residue 5LD K 204 |
| Chain | Residue |
| D | ARG92 |
| D | ARG114 |
| D | SER191 |
| D | LYS193 |
| K | HIS40 |
| K | HIS162 |
| K | HIS163 |
| K | GLU166 |
| K | LYS170 |
| K | MN202 |
| K | MN203 |
| K | HOH333 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue MN L 201 |
| Chain | Residue |
| D | HIS163 |
| D | 5LD202 |
| D | HOH328 |
| L | HIS66 |
| L | GLU70 |
| L | HIS138 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue MN L 202 |
| Chain | Residue |
| L | HIS40 |
| L | HIS162 |
| L | GLU166 |
| L | 5LD204 |
| site_id | AF8 |
| Number of Residues | 2 |
| Details | binding site for residue MN L 203 |
| Chain | Residue |
| L | HIS163 |
| L | 5LD204 |
| site_id | AF9 |
| Number of Residues | 12 |
| Details | binding site for residue 5LD L 204 |
| Chain | Residue |
| I | ARG92 |
| I | ARG114 |
| I | SER191 |
| I | LYS193 |
| L | HIS40 |
| L | HIS162 |
| L | HIS163 |
| L | GLU166 |
| L | LYS170 |
| L | MN202 |
| L | MN203 |
| L | HOH307 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue MG L 205 |
| Chain | Residue |
| A | HOH433 |
| L | GLN7 |
| L | GLN82 |
| L | HOH398 |
| L | HOH408 |
| L | HOH410 |
Functional Information from PROSITE/UniProt
| site_id | PS00954 |
| Number of Residues | 14 |
| Details | IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. VDdHHtsEdcAIVL |
| Chain | Residue | Details |
| A | VAL63-LEU76 |
| site_id | PS00955 |
| Number of Residues | 13 |
| Details | IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GaNdHHkaESaFK |
| Chain | Residue | Details |
| A | GLY158-LYS170 |
