6FWH
Acanthamoeba IGPD in complex with R-C348 to 1.7A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000105 | biological_process | L-histidine biosynthetic process |
A | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
A | 0016829 | molecular_function | lyase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0000105 | biological_process | L-histidine biosynthetic process |
B | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
B | 0016829 | molecular_function | lyase activity |
B | 0046872 | molecular_function | metal ion binding |
C | 0000105 | biological_process | L-histidine biosynthetic process |
C | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
C | 0016829 | molecular_function | lyase activity |
C | 0046872 | molecular_function | metal ion binding |
D | 0000105 | biological_process | L-histidine biosynthetic process |
D | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
D | 0016829 | molecular_function | lyase activity |
D | 0046872 | molecular_function | metal ion binding |
E | 0000105 | biological_process | L-histidine biosynthetic process |
E | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
E | 0016829 | molecular_function | lyase activity |
E | 0046872 | molecular_function | metal ion binding |
F | 0000105 | biological_process | L-histidine biosynthetic process |
F | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
F | 0016829 | molecular_function | lyase activity |
F | 0046872 | molecular_function | metal ion binding |
G | 0000105 | biological_process | L-histidine biosynthetic process |
G | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
G | 0016829 | molecular_function | lyase activity |
G | 0046872 | molecular_function | metal ion binding |
H | 0000105 | biological_process | L-histidine biosynthetic process |
H | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
H | 0016829 | molecular_function | lyase activity |
H | 0046872 | molecular_function | metal ion binding |
I | 0000105 | biological_process | L-histidine biosynthetic process |
I | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
I | 0016829 | molecular_function | lyase activity |
I | 0046872 | molecular_function | metal ion binding |
J | 0000105 | biological_process | L-histidine biosynthetic process |
J | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
J | 0016829 | molecular_function | lyase activity |
J | 0046872 | molecular_function | metal ion binding |
K | 0000105 | biological_process | L-histidine biosynthetic process |
K | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
K | 0016829 | molecular_function | lyase activity |
K | 0046872 | molecular_function | metal ion binding |
L | 0000105 | biological_process | L-histidine biosynthetic process |
L | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
L | 0016829 | molecular_function | lyase activity |
L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue MN A 201 |
Chain | Residue |
A | HIS40 |
A | HIS162 |
A | GLU166 |
A | 5LD203 |
F | HIS67 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MN A 202 |
Chain | Residue |
B | 5LD203 |
B | HOH318 |
A | HIS66 |
A | GLU70 |
A | HIS138 |
B | HIS163 |
site_id | AC3 |
Number of Residues | 16 |
Details | binding site for residue 5LD A 203 |
Chain | Residue |
A | HIS40 |
A | HIS162 |
A | HIS163 |
A | GLU166 |
A | LYS170 |
A | MN201 |
A | HOH345 |
C | ARG92 |
C | ARG114 |
C | SER191 |
C | LYS193 |
F | GLU14 |
F | HIS66 |
F | HIS67 |
F | GLU70 |
F | MN201 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue MN B 201 |
Chain | Residue |
A | HIS67 |
B | HIS40 |
B | HIS162 |
B | GLU166 |
B | 5LD203 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue MN B 202 |
Chain | Residue |
B | HIS66 |
B | GLU70 |
B | HIS138 |
B | 5LD204 |
G | HIS163 |
G | HOH318 |
site_id | AC6 |
Number of Residues | 16 |
Details | binding site for residue 5LD B 203 |
Chain | Residue |
A | GLU14 |
A | HIS66 |
A | HIS67 |
A | GLU70 |
A | MN202 |
B | HIS40 |
B | HIS162 |
B | HIS163 |
B | GLU166 |
B | LYS170 |
B | MN201 |
B | HOH356 |
K | ARG92 |
K | ARG114 |
K | SER191 |
K | LYS193 |
site_id | AC7 |
Number of Residues | 16 |
Details | binding site for residue 5LD B 204 |
Chain | Residue |
B | GLU14 |
B | HIS66 |
B | HIS67 |
B | GLU70 |
B | MN202 |
B | HOH319 |
G | HIS40 |
G | HIS162 |
G | HIS163 |
G | GLU166 |
G | LYS170 |
G | MN202 |
L | ARG92 |
L | ARG114 |
L | SER191 |
L | LYS193 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue MN C 201 |
Chain | Residue |
C | HIS40 |
C | HIS162 |
C | GLU166 |
C | 5LD204 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue MN C 202 |
Chain | Residue |
C | HIS163 |
C | 5LD204 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue MN C 203 |
Chain | Residue |
C | HIS66 |
C | GLU70 |
C | HIS138 |
J | HIS163 |
J | 5LD202 |
J | HOH321 |
site_id | AD2 |
Number of Residues | 12 |
Details | binding site for residue 5LD C 204 |
Chain | Residue |
C | HIS40 |
C | HIS162 |
C | HIS163 |
C | GLU166 |
C | LYS170 |
C | MN201 |
C | MN202 |
C | HOH308 |
E | ARG92 |
E | ARG114 |
E | SER191 |
E | LYS193 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue MN D 201 |
Chain | Residue |
D | HIS40 |
D | HIS162 |
D | GLU166 |
D | 5LD202 |
L | HIS67 |
site_id | AD4 |
Number of Residues | 16 |
Details | binding site for residue 5LD D 202 |
Chain | Residue |
B | ARG92 |
B | ARG114 |
B | SER191 |
B | LYS193 |
D | HIS40 |
D | HIS162 |
D | HIS163 |
D | GLU166 |
D | LYS170 |
D | MN201 |
D | HOH310 |
L | GLU14 |
L | HIS66 |
L | HIS67 |
L | GLU70 |
L | MN201 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue MN E 201 |
Chain | Residue |
E | HIS40 |
E | HIS162 |
E | GLU166 |
E | 5LD202 |
K | HIS67 |
site_id | AD6 |
Number of Residues | 16 |
Details | binding site for residue 5LD E 202 |
Chain | Residue |
A | ARG92 |
A | ARG114 |
A | SER191 |
A | LYS193 |
E | HIS40 |
E | HIS162 |
E | HIS163 |
E | GLU166 |
E | LYS170 |
E | MN201 |
E | HOH342 |
K | GLU14 |
K | HIS66 |
K | HIS67 |
K | GLU70 |
K | MN201 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue MN F 201 |
Chain | Residue |
A | HIS163 |
A | 5LD203 |
F | HIS66 |
F | GLU70 |
F | HIS138 |
F | HOH317 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue MN F 202 |
Chain | Residue |
F | HIS40 |
F | HIS162 |
F | GLU166 |
F | 5LD203 |
G | HIS67 |
site_id | AD9 |
Number of Residues | 16 |
Details | binding site for residue 5LD F 203 |
Chain | Residue |
F | HIS40 |
F | HIS162 |
F | HIS163 |
F | GLU166 |
F | LYS170 |
F | MN202 |
F | HOH352 |
G | GLU14 |
G | HIS66 |
G | HIS67 |
G | GLU70 |
G | MN201 |
H | ARG92 |
H | ARG114 |
H | SER191 |
H | LYS193 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue MN G 201 |
Chain | Residue |
F | HIS163 |
F | 5LD203 |
F | HOH321 |
G | HIS66 |
G | GLU70 |
G | HIS138 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue MN G 202 |
Chain | Residue |
B | HIS67 |
B | 5LD204 |
G | HIS40 |
G | HIS162 |
G | GLU166 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue MN H 201 |
Chain | Residue |
H | HIS40 |
H | HIS162 |
H | GLU166 |
H | 5LD204 |
site_id | AE4 |
Number of Residues | 3 |
Details | binding site for residue MN H 202 |
Chain | Residue |
H | HIS163 |
H | 5LD204 |
H | HOH347 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue MN H 203 |
Chain | Residue |
H | HIS66 |
H | GLU70 |
H | HIS138 |
H | HOH339 |
I | HIS163 |
I | 5LD202 |
site_id | AE6 |
Number of Residues | 13 |
Details | binding site for residue 5LD H 204 |
Chain | Residue |
H | HIS40 |
H | HIS162 |
H | HIS163 |
H | GLU166 |
H | LYS170 |
H | MN201 |
H | MN202 |
H | HOH326 |
H | HOH347 |
J | ARG92 |
J | ARG114 |
J | SER191 |
J | LYS193 |
site_id | AE7 |
Number of Residues | 5 |
Details | binding site for residue MN I 201 |
Chain | Residue |
H | HIS67 |
I | HIS40 |
I | HIS162 |
I | GLU166 |
I | 5LD202 |
site_id | AE8 |
Number of Residues | 17 |
Details | binding site for residue 5LD I 202 |
Chain | Residue |
G | ARG92 |
G | ARG114 |
G | SER191 |
G | THR192 |
G | LYS193 |
H | GLU14 |
H | HIS66 |
H | HIS67 |
H | GLU70 |
H | MN203 |
I | HIS40 |
I | HIS162 |
I | HIS163 |
I | GLU166 |
I | LYS170 |
I | MN201 |
I | HOH364 |
site_id | AE9 |
Number of Residues | 5 |
Details | binding site for residue MN J 201 |
Chain | Residue |
C | HIS67 |
J | HIS40 |
J | HIS162 |
J | GLU166 |
J | 5LD202 |
site_id | AF1 |
Number of Residues | 17 |
Details | binding site for residue 5LD J 202 |
Chain | Residue |
C | GLU14 |
C | HIS66 |
C | HIS67 |
C | GLU70 |
C | MN203 |
F | ARG92 |
F | ARG114 |
F | SER191 |
F | LYS193 |
J | HIS40 |
J | HIS162 |
J | HIS163 |
J | GLU166 |
J | LYS170 |
J | MN201 |
J | HOH321 |
J | HOH344 |
site_id | AF2 |
Number of Residues | 6 |
Details | binding site for residue MN K 201 |
Chain | Residue |
E | HIS163 |
E | 5LD202 |
K | HIS66 |
K | GLU70 |
K | HIS138 |
K | HOH321 |
site_id | AF3 |
Number of Residues | 4 |
Details | binding site for residue MN K 202 |
Chain | Residue |
K | HIS40 |
K | HIS162 |
K | GLU166 |
K | 5LD204 |
site_id | AF4 |
Number of Residues | 2 |
Details | binding site for residue MN K 203 |
Chain | Residue |
K | HIS163 |
K | 5LD204 |
site_id | AF5 |
Number of Residues | 12 |
Details | binding site for residue 5LD K 204 |
Chain | Residue |
D | ARG92 |
D | ARG114 |
D | SER191 |
D | LYS193 |
K | HIS40 |
K | HIS162 |
K | HIS163 |
K | GLU166 |
K | LYS170 |
K | MN202 |
K | MN203 |
K | HOH333 |
site_id | AF6 |
Number of Residues | 6 |
Details | binding site for residue MN L 201 |
Chain | Residue |
D | HIS163 |
D | 5LD202 |
D | HOH328 |
L | HIS66 |
L | GLU70 |
L | HIS138 |
site_id | AF7 |
Number of Residues | 4 |
Details | binding site for residue MN L 202 |
Chain | Residue |
L | HIS40 |
L | HIS162 |
L | GLU166 |
L | 5LD204 |
site_id | AF8 |
Number of Residues | 2 |
Details | binding site for residue MN L 203 |
Chain | Residue |
L | HIS163 |
L | 5LD204 |
site_id | AF9 |
Number of Residues | 12 |
Details | binding site for residue 5LD L 204 |
Chain | Residue |
I | ARG92 |
I | ARG114 |
I | SER191 |
I | LYS193 |
L | HIS40 |
L | HIS162 |
L | HIS163 |
L | GLU166 |
L | LYS170 |
L | MN202 |
L | MN203 |
L | HOH307 |
site_id | AG1 |
Number of Residues | 6 |
Details | binding site for residue MG L 205 |
Chain | Residue |
A | HOH433 |
L | GLN7 |
L | GLN82 |
L | HOH398 |
L | HOH408 |
L | HOH410 |
Functional Information from PROSITE/UniProt
site_id | PS00954 |
Number of Residues | 14 |
Details | IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. VDdHHtsEdcAIVL |
Chain | Residue | Details |
A | VAL63-LEU76 |
site_id | PS00955 |
Number of Residues | 13 |
Details | IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GaNdHHkaESaFK |
Chain | Residue | Details |
A | GLY158-LYS170 |