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6FUT

Complement factor D in complex with the inhibitor (S)-3'-(aminomethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-[1,1'-biphenyl]-3-carboxamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0008236molecular_functionserine-type peptidase activity
A0009617biological_processresponse to bacterium
A0031093cellular_componentplatelet alpha granule lumen
A0034774cellular_componentsecretory granule lumen
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue E82 A 301
ChainResidue
AHIS146
AARG218
AVAL219
ACYS220
ASER240
ASER244
ASIN302
AHOH410
AHOH509
AHOH517
AHOH521
AASP189
AHOH529
ASER190
ACYS191
ALYS192
ASER195
ATHR214
ASER215
ASER217

site_idAC2
Number of Residues9
Detailsbinding site for residue SIN A 302
ChainResidue
ALEU41
AHIS57
ALYS192
AGLY193
ASER195
AE82301
AHOH403
AHOH445
AHOH461

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

224931

PDB entries from 2024-09-11

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