6FQY
Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019521 | biological_process | D-gluconate metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004616 | molecular_function | phosphogluconate dehydrogenase (decarboxylating) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019521 | biological_process | D-gluconate metabolic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue NAP A 501 |
| Chain | Residue |
| A | ALA10 |
| A | ASN31 |
| A | ARG32 |
| A | THR33 |
| A | ARG36 |
| A | LYS75 |
| A | ALA79 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | GLY129 |
| A | LYS182 |
| A | ILE367 |
| A | ASN102 |
| A | SER128 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | ASP192 |
| A | LEU226 |
| A | SER228 |
| A | LEU230 |
| A | ILE231 |
| A | LYS331 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue NAP B 500 |
| Chain | Residue |
| B | ALA10 |
| B | VAL11 |
| B | ASN31 |
| B | ARG32 |
| B | THR33 |
| B | ARG36 |
| B | LYS75 |
| B | ALA79 |
