6FQJ
GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| E | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| E | 0016020 | cellular_component | membrane |
| F | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| F | 0016020 | cellular_component | membrane |
| G | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| G | 0016020 | cellular_component | membrane |
| H | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| H | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue ZK1 A 301 |
| Chain | Residue |
| A | GLU13 |
| A | GLU193 |
| A | THR195 |
| A | MET196 |
| A | TYR220 |
| A | TYR16 |
| A | TYR61 |
| A | PRO89 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR174 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue ZK1 B 301 |
| Chain | Residue |
| B | GLU13 |
| B | TYR16 |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| B | THR174 |
| B | GLU193 |
| B | MET196 |
| B | TYR220 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue ZK1 C 301 |
| Chain | Residue |
| C | GLU13 |
| C | TYR16 |
| C | TYR61 |
| C | PRO89 |
| C | LEU90 |
| C | THR91 |
| C | ARG96 |
| C | GLY141 |
| C | SER142 |
| C | THR174 |
| C | GLU193 |
| C | MET196 |
| C | TYR220 |
| C | HOH411 |
| C | HOH461 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue ZK1 D 301 |
| Chain | Residue |
| D | GLU13 |
| D | TYR16 |
| D | TYR61 |
| D | PRO89 |
| D | THR91 |
| D | ARG96 |
| D | GLY141 |
| D | SER142 |
| D | THR174 |
| D | GLU193 |
| D | MET196 |
| D | TYR220 |
| D | HOH413 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue ZK1 E 301 |
| Chain | Residue |
| E | GLU13 |
| E | TYR16 |
| E | TYR61 |
| E | PRO89 |
| E | THR91 |
| E | ARG96 |
| E | GLY141 |
| E | SER142 |
| E | THR174 |
| E | GLU193 |
| E | MET196 |
| E | TYR220 |
| E | HOH464 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue ZK1 F 301 |
| Chain | Residue |
| F | GLU13 |
| F | TYR16 |
| F | TYR61 |
| F | PRO89 |
| F | LEU90 |
| F | THR91 |
| F | ARG96 |
| F | GLY141 |
| F | SER142 |
| F | THR174 |
| F | GLU193 |
| F | THR195 |
| F | MET196 |
| F | TYR220 |
| F | HOH417 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue ZK1 G 301 |
| Chain | Residue |
| G | GLU13 |
| G | TYR61 |
| G | PRO89 |
| G | LEU90 |
| G | THR91 |
| G | ARG96 |
| G | GLY141 |
| G | SER142 |
| G | THR174 |
| G | GLU193 |
| G | MET196 |
| G | TYR220 |
| G | HOH403 |
| G | HOH457 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue ZK1 H 301 |
| Chain | Residue |
| H | LEU90 |
| H | THR91 |
| H | ARG96 |
| H | GLY141 |
| H | SER142 |
| H | THR174 |
| H | GLU193 |
| H | MET196 |
| H | TYR220 |
| H | HOH401 |
| H | HOH414 |
| H | HOH449 |
| H | GLU13 |
| H | TYR61 |
| H | PRO89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
