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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FQJ

GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
F	0015276	molecular_function	ligand-gated monoatomic ion channel activity
F	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue ZK1 A 301

Chain	Residue
A	GLU13
A	GLU193
A	THR195
A	MET196
A	TYR220
A	TYR16
A	TYR61
A	PRO89
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR174

site_id	AC2
Number of Residues	13
Details	binding site for residue ZK1 B 301

Chain	Residue
B	GLU13
B	TYR16
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR174
B	GLU193
B	MET196
B	TYR220

site_id	AC3
Number of Residues	15
Details	binding site for residue ZK1 C 301

Chain	Residue
C	GLU13
C	TYR16
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR174
C	GLU193
C	MET196
C	TYR220
C	HOH411
C	HOH461

site_id	AC4
Number of Residues	13
Details	binding site for residue ZK1 D 301

Chain	Residue
D	GLU13
D	TYR16
D	TYR61
D	PRO89
D	THR91
D	ARG96
D	GLY141
D	SER142
D	THR174
D	GLU193
D	MET196
D	TYR220
D	HOH413

site_id	AC5
Number of Residues	13
Details	binding site for residue ZK1 E 301

Chain	Residue
E	GLU13
E	TYR16
E	TYR61
E	PRO89
E	THR91
E	ARG96
E	GLY141
E	SER142
E	THR174
E	GLU193
E	MET196
E	TYR220
E	HOH464

site_id	AC6
Number of Residues	15
Details	binding site for residue ZK1 F 301

Chain	Residue
F	GLU13
F	TYR16
F	TYR61
F	PRO89
F	LEU90
F	THR91
F	ARG96
F	GLY141
F	SER142
F	THR174
F	GLU193
F	THR195
F	MET196
F	TYR220
F	HOH417

site_id	AC7
Number of Residues	14
Details	binding site for residue ZK1 G 301

Chain	Residue
G	GLU13
G	TYR61
G	PRO89
G	LEU90
G	THR91
G	ARG96
G	GLY141
G	SER142
G	THR174
G	GLU193
G	MET196
G	TYR220
G	HOH403
G	HOH457

site_id	AC8
Number of Residues	15
Details	binding site for residue ZK1 H 301

Chain	Residue
H	LEU90
H	THR91
H	ARG96
H	GLY141
H	SER142
H	THR174
H	GLU193
H	MET196
H	TYR220
H	HOH401
H	HOH414
H	HOH449
H	GLU13
H	TYR61
H	PRO89

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269\|PubMed:11086992, ECO:0000269\|PubMed:16483599, ECO:0007744\|PDB:1FTJ, ECO:0007744\|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
D	PRO89
A	THR91
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
E	PRO89
E	THR91
E	ARG96
E	SER142
E	THR143
A	ARG96
E	GLU193
F	PRO89
F	THR91
F	ARG96
F	SER142
F	THR143
F	GLU193
G	PRO89
G	THR91
G	ARG96
A	SER142
G	SER142
G	THR143
G	GLU193
H	PRO89
H	THR91
H	ARG96
H	SER142
H	THR143
H	GLU193
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

site_id	SWS_FT_FI2
Number of Residues	24
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ARG64
D	ARG64
D	ARG148
D	LYS240
E	ARG64
E	ARG148
E	LYS240
F	ARG64
F	ARG148
F	LYS240
G	ARG64
A	ARG148
G	ARG148
G	LYS240
H	ARG64
H	ARG148
H	LYS240
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269\|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121
D	ILE121
E	ILE121
F	ILE121
G	ILE121
H	ILE121

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150
D	SER150
E	SER150
F	SER150
G	SER150
H	SER150

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269\|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184
E	SER184
F	SER184
G	SER184
H	SER184

site_id	SWS_FT_FI6
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3
D	ASN3
E	ASN3
F	ASN3
G	ASN3
H	ASN3

223166

PDB entries from 2024-07-31

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