Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FO0

CryoEM structure of bovine cytochrome bc1 in complex with the anti-malarial compound GSK932121

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
B	0004222	molecular_function	metalloendopeptidase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006508	biological_process	proteolysis
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	0048039	molecular_function	ubiquinone binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005750	cellular_component	mitochondrial respiratory chain complex III
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome
D	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005750	cellular_component	mitochondrial respiratory chain complex III
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0070469	cellular_component	respirasome
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0070469	cellular_component	respirasome
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0070469	cellular_component	respirasome
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005750	cellular_component	mitochondrial respiratory chain complex III
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0070469	cellular_component	respirasome
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0046872	molecular_function	metal ion binding
N	0070469	cellular_component	respirasome
O	0004222	molecular_function	metalloendopeptidase activity
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006508	biological_process	proteolysis
O	0046872	molecular_function	metal ion binding
O	0070469	cellular_component	respirasome
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005750	cellular_component	mitochondrial respiratory chain complex III
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0022904	biological_process	respiratory electron transport chain
P	0031966	cellular_component	mitochondrial membrane
P	0045275	cellular_component	respiratory chain complex III
P	0046872	molecular_function	metal ion binding
P	0048039	molecular_function	ubiquinone binding
P	0070469	cellular_component	respirasome
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005750	cellular_component	mitochondrial respiratory chain complex III
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Q	0009055	molecular_function	electron transfer activity
Q	0020037	molecular_function	heme binding
Q	0046872	molecular_function	metal ion binding
Q	0070469	cellular_component	respirasome
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005750	cellular_component	mitochondrial respiratory chain complex III
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0016020	cellular_component	membrane
R	0016491	molecular_function	oxidoreductase activity
R	0046872	molecular_function	metal ion binding
R	0051537	molecular_function	2 iron, 2 sulfur cluster binding
R	0070469	cellular_component	respirasome
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005750	cellular_component	mitochondrial respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0070469	cellular_component	respirasome
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005750	cellular_component	mitochondrial respiratory chain complex III
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0070469	cellular_component	respirasome
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005750	cellular_component	mitochondrial respiratory chain complex III
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0070469	cellular_component	respirasome
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005750	cellular_component	mitochondrial respiratory chain complex III
W	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
W	0070469	cellular_component	respirasome

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue HEM P 501

Chain	Residue
P	GLN44
P	GLY130
P	LEU133
P	PRO134
P	PHE179
P	HIS182
P	PHE183
P	ILE45
P	GLY48
P	LEU49
P	LEU51
P	ARG80
P	HIS83
P	ALA84
P	ALA127

site_id	AC2
Number of Residues	13
Details	binding site for residue HEM P 502

Chain	Residue
P	TRP31
P	GLY34
P	LEU37
P	HIS97
P	ARG100
P	SER106
P	TRP113
P	GLY116
P	LEU119
P	HIS196
P	SER205
P	ASN206
P	G8U503

site_id	AC3
Number of Residues	9
Details	binding site for residue G8U P 503

Chain	Residue
P	PHE18
P	LEU21
P	SER35
P	GLY38
P	MET194
P	LEU197
P	PHE220
P	ASP228
P	HEM502

site_id	AC4
Number of Residues	12
Details	binding site for residue HEC Q 501

Chain	Residue
Q	VAL36
Q	CYS37
Q	CYS40
Q	HIS41
Q	ASN105
Q	PRO110
Q	TYR126
Q	LEU131
Q	PHE153
Q	ILE158
Q	MET160
Q	PRO163

site_id	AC5
Number of Residues	15
Details	binding site for residue HEM C 501

Chain	Residue
C	GLN44
C	ILE45
C	GLY48
C	LEU49
C	LEU51
C	ARG80
C	HIS83
C	ALA84
C	ALA127
C	GLY130
C	LEU133
C	PRO134
C	PHE179
C	HIS182
C	PHE183

site_id	AC6
Number of Residues	14
Details	binding site for residue HEM C 502

Chain	Residue
C	TRP31
C	GLY34
C	LEU37
C	HIS97
C	ARG100
C	SER106
C	TRP113
C	GLY116
C	LEU119
C	HIS196
C	LEU197
C	SER205
C	ASN206
C	G8U503

site_id	AC7
Number of Residues	8
Details	binding site for residue G8U C 503

Chain	Residue
C	PHE18
C	LEU21
C	SER35
C	GLY38
C	MET194
C	PHE220
C	ASP228
C	HEM502

site_id	AC8
Number of Residues	13
Details	binding site for residue HEC D 501

Chain	Residue
D	VAL36
D	CYS37
D	CYS40
D	HIS41
D	ASN105
D	LEU113
D	TYR126
D	LEU130
D	LEU131
D	PHE153
D	ILE158
D	MET160
D	PRO163

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT

Chain	Residue	Details
O	GLY54-THR77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
W	VAL1-PHE20
C	TRP77-VAL98
C	TRP113-LEU133
C	PHE178-LEU198
C	ILE226-ALA246
C	LEU288-HIS308
C	LEU320-GLY340
C	TYR347-PRO367
J	VAL1-PHE20
H	LYS29
H	LYS72
P	ILE226-ALA246
P	LEU288-HIS308
P	LEU320-GLY340
P	TYR347-PRO367
C	PHE33-MET53

site_id	SWS_FT_FI2
Number of Residues	50
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
W	ALA21-ILE46
J	ALA21-ILE46
S	LYS95
F	LYS18
F	LYS82
F	LYS95

site_id	SWS_FT_FI3
Number of Residues	32
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:9651245

Chain	Residue	Details
W	ASN47-GLU63
J	ASN47-GLU63
F	LYS77
F	LYS87

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9CQ69

Chain	Residue	Details
T	LYS32
E	SER163
G	LYS32
R	CYS158
R	HIS161
R	SER163
E	CYS139
E	HIS141
E	CYS158
E	HIS161

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:9651245, ECO:0007744\|PDB:1BE3, ECO:0007744\|PDB:1BGY

Chain	Residue	Details
Q	HIS41
D	HIS41

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:9651245, ECO:0007744\|PDB:1BE3

Chain	Residue	Details
Q	MET160
D	MET160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)