6FDF
Crystal structure of S. pombe Dnmt2 methyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0002946 | biological_process | tRNA C5-cytosine methylation |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009008 | molecular_function | DNA-methyltransferase activity |
| A | 0016427 | molecular_function | tRNA (cytidine) methyltransferase activity |
| A | 0016428 | molecular_function | tRNA (cytidine-5-)-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0002946 | biological_process | tRNA C5-cytosine methylation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009008 | molecular_function | DNA-methyltransferase activity |
| B | 0016427 | molecular_function | tRNA (cytidine) methyltransferase activity |
| B | 0016428 | molecular_function | tRNA (cytidine-5-)-methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0002946 | biological_process | tRNA C5-cytosine methylation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008033 | biological_process | tRNA processing |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0009008 | molecular_function | DNA-methyltransferase activity |
| C | 0016427 | molecular_function | tRNA (cytidine) methyltransferase activity |
| C | 0016428 | molecular_function | tRNA (cytidine-5-)-methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0002946 | biological_process | tRNA C5-cytosine methylation |
| D | 0003723 | molecular_function | RNA binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008033 | biological_process | tRNA processing |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0009008 | molecular_function | DNA-methyltransferase activity |
| D | 0016427 | molecular_function | tRNA (cytidine) methyltransferase activity |
| D | 0016428 | molecular_function | tRNA (cytidine-5-)-methyltransferase activity |
| D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue SAH A 401 |
| Chain | Residue |
| A | TYR13 |
| A | ASP58 |
| A | ILE59 |
| A | SER78 |
| A | ALA100 |
| A | ASN310 |
| A | SER311 |
| A | ILE312 |
| A | HOH511 |
| A | HOH530 |
| B | GOL403 |
| A | SER14 |
| A | GLY15 |
| A | ILE16 |
| A | GLY18 |
| A | ASP37 |
| A | ILE38 |
| A | ASN39 |
| A | MET57 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | GLN224 |
| A | PHE225 |
| A | ASP226 |
| A | CYS236 |
| A | VAL246 |
| A | GLY248 |
| A | ALA249 |
| A | GLY250 |
| A | HOH550 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | LEU25 |
| A | ASN27 |
| A | LYS315 |
| A | HOH517 |
| B | GLN224 |
| B | VAL246 |
| B | GLN247 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | TRP221 |
| A | GLN224 |
| A | VAL246 |
| A | GLN247 |
| B | LEU25 |
| B | ASN27 |
| B | GLU187 |
| B | LYS315 |
| B | HOH528 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | SER216 |
| A | ASN219 |
| A | HOH629 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | binding site for residue SAH B 401 |
| Chain | Residue |
| B | TYR13 |
| B | SER14 |
| B | GLY15 |
| B | ILE16 |
| B | GLY18 |
| B | ASP37 |
| B | ILE38 |
| B | ASN39 |
| B | MET57 |
| B | ASP58 |
| B | ILE59 |
| B | SER78 |
| B | SER80 |
| B | PRO96 |
| B | ALA100 |
| B | ASN310 |
| B | SER311 |
| B | HOH517 |
| B | HOH529 |
| B | HOH543 |
| B | HOH602 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | GLN224 |
| B | PHE225 |
| B | ASP226 |
| B | CYS236 |
| B | VAL246 |
| B | GLY248 |
| B | ALA249 |
| B | GLY250 |
| B | HOH511 |
| B | HOH572 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| A | ILE38 |
| A | SAH401 |
| B | TRP177 |
| B | SER178 |
| B | ASP181 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | LYS65 |
| B | ASP68 |
| B | ALA69 |
| site_id | AD1 |
| Number of Residues | 19 |
| Details | binding site for residue SAH C 401 |
| Chain | Residue |
| C | PRO83 |
| C | ASN310 |
| C | SER311 |
| C | ILE312 |
| C | HOH574 |
| C | HOH602 |
| C | TYR13 |
| C | SER14 |
| C | GLY15 |
| C | ILE16 |
| C | GLY18 |
| C | ASP37 |
| C | ILE38 |
| C | ASN39 |
| C | MET57 |
| C | ASP58 |
| C | ILE59 |
| C | SER78 |
| C | GLN82 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| C | PHE225 |
| C | ASP226 |
| C | CYS236 |
| C | VAL246 |
| C | GLY248 |
| C | ALA249 |
| C | GLY250 |
| C | HOH578 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| A | HOH501 |
| C | LYS196 |
| C | ASP200 |
| C | TYR201 |
| C | ARG284 |
| C | HOH513 |
| C | HOH663 |
| site_id | AD4 |
| Number of Residues | 25 |
| Details | binding site for residue SAH D 401 |
| Chain | Residue |
| D | TYR13 |
| D | SER14 |
| D | ILE16 |
| D | GLY17 |
| D | GLY18 |
| D | ASP37 |
| D | ILE38 |
| D | MET57 |
| D | ASP58 |
| D | ILE59 |
| D | SER78 |
| D | PRO79 |
| D | SER80 |
| D | CYS81 |
| D | GLN82 |
| D | PRO83 |
| D | ASN310 |
| D | SER311 |
| D | ILE312 |
| D | HOH509 |
| D | HOH511 |
| D | HOH516 |
| D | HOH572 |
| D | HOH594 |
| D | HOH638 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 402 |
| Chain | Residue |
| D | GLN224 |
| D | PHE225 |
| D | ASP226 |
| D | CYS236 |
| D | VAL246 |
| D | GLY248 |
| D | ALA249 |
| D | GLY250 |
| D | HOH541 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 403 |
| Chain | Residue |
| C | PHE183 |
| C | VAL188 |
| D | ASN39 |
| D | GLN41 |
| D | ARG306 |
| D | LEU307 |
| D | HOH501 |
| D | HOH524 |
Functional Information from PROSITE/UniProt
| site_id | PS00095 |
| Number of Residues | 19 |
| Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RllGNSInVkVvsyLislL |
| Chain | Residue | Details |
| A | ARG306-LEU324 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016 |
| Chain | Residue | Details |
| A | CYS81 | |
| B | CYS81 | |
| C | CYS81 | |
| D | CYS81 |
