6F6D
The catalytic domain of KDM6B in complex with H3(17-33)K18IA21M peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue FE A 1701 |
| Chain | Residue |
| A | HIS1390 |
| A | GLU1392 |
| A | HIS1470 |
| A | AKG1703 |
| A | HOH2098 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1702 |
| Chain | Residue |
| A | CYS1575 |
| A | CYS1578 |
| A | CYS1602 |
| A | CYS1605 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue AKG A 1703 |
| Chain | Residue |
| A | LYS1381 |
| A | THR1387 |
| A | HIS1390 |
| A | GLU1392 |
| A | SER1398 |
| A | ASN1400 |
| A | HIS1470 |
| A | VAL1472 |
| A | ALA1482 |
| A | FE1701 |
| A | HOH1815 |
| A | HOH1892 |
| A | HOH2098 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue TBU A 1704 |
| Chain | Residue |
| A | HOH1804 |
| A | HOH1813 |
| A | HOH1985 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue TBU A 1705 |
| Chain | Residue |
| A | PHE1288 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue TBU A 1706 |
| Chain | Residue |
| A | THR1242 |
| A | HOH2151 |
| A | HOH2168 |
| B | ARG26 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| B | ARG17 | |
| A | GLU1392 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | ILE18 | |
| A | CYS1575 | |
| A | CYS1578 | |
| A | CYS1602 | |
| A | CYS1605 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS23 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| B | ARG26 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS27 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| B | SER28 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| B | ILE18 |
