6F4Q
Human JMJD5 (Q275C) in complex with Mn(II), NOG and RPS6-A138C (129-144) (complex-2)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 501 |
| Chain | Residue |
| A | HIS321 |
| A | ASP323 |
| A | HIS400 |
| A | OGA502 |
| A | HOH786 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue OGA A 502 |
| Chain | Residue |
| A | ASP323 |
| A | ASN327 |
| A | LEU329 |
| A | LYS336 |
| A | HIS400 |
| A | VAL402 |
| A | SER412 |
| A | TRP414 |
| A | MN501 |
| A | HOH764 |
| A | TYR272 |
| A | TRP310 |
| A | SER318 |
| A | HIS321 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue TRS A 503 |
| Chain | Residue |
| A | LEU200 |
| A | VAL201 |
| A | GLY203 |
| A | GLN326 |
| A | TYR350 |
| A | LYS372 |
| A | PHE373 |
| A | VAL396 |
| A | HOH627 |
| A | HOH636 |
| A | HOH648 |
| A | HOH685 |
| A | HOH696 |
| A | HOH865 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ARG196 |
| A | ARG268 |
| A | ASP269 |
| A | SER296 |
| A | LEU297 |
| A | HOH630 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | ARG189 |
| A | PRO190 |
| A | GLU266 |
| A | ASP293 |
| A | TYR294 |
| A | HOH693 |
| A | HOH720 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 145 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29459673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22851697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29459673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29563586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100311","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3UYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GJZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22851697","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24100311","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4GJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22851697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29459673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29563586","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GJZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"(3R)-3-hydroxyarginine","evidences":[{"source":"PubMed","id":"29563586","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
