6F1T

Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0000166	molecular_function	nucleotide binding
H	0001738	biological_process	morphogenesis of a polarized epithelium
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005884	cellular_component	actin filament
H	0005886	cellular_component	plasma membrane
H	0005903	cellular_component	brush border
H	0005911	cellular_component	cell-cell junction
H	0005912	cellular_component	adherens junction
H	0005925	cellular_component	focal adhesion
H	0007017	biological_process	microtubule-based process
H	0007163	biological_process	establishment or maintenance of cell polarity
H	0007409	biological_process	axonogenesis
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0019894	molecular_function	kinesin binding
H	0019901	molecular_function	protein kinase binding
H	0030027	cellular_component	lamellipodium
H	0030235	molecular_function	nitric-oxide synthase regulator activity
H	0030424	cellular_component	axon
H	0030863	cellular_component	cortical cytoskeleton
H	0030957	molecular_function	Tat protein binding
H	0032991	cellular_component	protein-containing complex
H	0034333	biological_process	adherens junction assembly
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042802	molecular_function	identical protein binding
H	0043296	cellular_component	apical junction complex
H	0044305	cellular_component	calyx of Held
H	0045176	biological_process	apical protein localization
H	0045202	cellular_component	synapse
H	0048870	biological_process	cell motility
H	0050998	molecular_function	nitric-oxide synthase binding
H	0051621	biological_process	regulation of norepinephrine uptake
H	0051726	biological_process	regulation of cell cycle
H	0070160	cellular_component	tight junction
H	0071896	biological_process	protein localization to adherens junction
H	0072749	biological_process	cellular response to cytochalasin B
H	0097433	cellular_component	dense body
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098871	cellular_component	postsynaptic actin cytoskeleton
H	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
H	0098974	biological_process	postsynaptic actin cytoskeleton organization
H	0098978	cellular_component	glutamatergic synapse
H	0141108	molecular_function	transporter regulator activity
H	0150111	biological_process	regulation of transepithelial transport
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1903076	biological_process	regulation of protein localization to plasma membrane
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
H	1990904	cellular_component	ribonucleoprotein complex
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005634	cellular_component	nucleus
J	0005856	cellular_component	cytoskeleton
J	0005869	cellular_component	dynactin complex
J	0007010	biological_process	cytoskeleton organization
J	0007017	biological_process	microtubule-based process
J	0098958	biological_process	retrograde axonal transport of mitochondrion
J	1904115	cellular_component	axon cytoplasm
K	0003779	molecular_function	actin binding
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0007017	biological_process	microtubule-based process
K	0008290	cellular_component	F-actin capping protein complex
K	0015629	cellular_component	actin cytoskeleton
K	0030036	biological_process	actin cytoskeleton organization
K	0030863	cellular_component	cortical cytoskeleton
K	0051015	molecular_function	actin filament binding
K	0051016	biological_process	barbed-end actin filament capping
K	0051693	biological_process	actin filament capping
L	0003779	molecular_function	actin binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0007017	biological_process	microtubule-based process
L	0008290	cellular_component	F-actin capping protein complex
L	0015629	cellular_component	actin cytoskeleton
L	0030017	cellular_component	sarcomere
L	0030036	biological_process	actin cytoskeleton organization
L	0051016	biological_process	barbed-end actin filament capping
L	0051693	biological_process	actin filament capping
L	0071203	cellular_component	WASH complex
U	0000776	cellular_component	kinetochore
U	0005813	cellular_component	centrosome
U	0005856	cellular_component	cytoskeleton
U	0005869	cellular_component	dynactin complex
U	0007017	biological_process	microtubule-based process
U	0007052	biological_process	mitotic spindle organization
U	0015630	cellular_component	microtubule cytoskeleton
U	0070840	molecular_function	dynein complex binding
V	0000776	cellular_component	kinetochore
V	0005813	cellular_component	centrosome
V	0005856	cellular_component	cytoskeleton
V	0005869	cellular_component	dynactin complex
V	0007017	biological_process	microtubule-based process
a	0005869	cellular_component	dynactin complex
a	0007017	biological_process	microtubule-based process
b	0005869	cellular_component	dynactin complex
b	0007017	biological_process	microtubule-based process
e	0007018	biological_process	microtubule-based movement
e	0030286	cellular_component	dynein complex
e	0045505	molecular_function	dynein intermediate chain binding
e	0051959	molecular_function	dynein light intermediate chain binding
f	0007018	biological_process	microtubule-based movement
f	0030286	cellular_component	dynein complex
f	0045505	molecular_function	dynein intermediate chain binding
f	0051959	molecular_function	dynein light intermediate chain binding
g	0001673	cellular_component	male germ cell nucleus
g	0003777	molecular_function	microtubule motor activity
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005813	cellular_component	centrosome
g	0005829	cellular_component	cytosol
g	0005856	cellular_component	cytoskeleton
g	0005868	cellular_component	cytoplasmic dynein complex
g	0005874	cellular_component	microtubule
g	0007018	biological_process	microtubule-based movement
g	0010970	biological_process	transport along microtubule
g	0030286	cellular_component	dynein complex
g	0031982	cellular_component	vesicle
g	0032388	biological_process	positive regulation of intracellular transport
g	0045503	molecular_function	dynein light chain binding
g	0045504	molecular_function	dynein heavy chain binding
g	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
h	0001673	cellular_component	male germ cell nucleus
h	0003777	molecular_function	microtubule motor activity
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0005813	cellular_component	centrosome
h	0005829	cellular_component	cytosol
h	0005856	cellular_component	cytoskeleton
h	0005868	cellular_component	cytoplasmic dynein complex
h	0005874	cellular_component	microtubule
h	0007018	biological_process	microtubule-based movement
h	0010970	biological_process	transport along microtubule
h	0030286	cellular_component	dynein complex
h	0031982	cellular_component	vesicle
h	0032388	biological_process	positive regulation of intracellular transport
h	0045503	molecular_function	dynein light chain binding
h	0045504	molecular_function	dynein heavy chain binding
h	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
i	0000166	molecular_function	nucleotide binding
i	0000226	biological_process	microtubule cytoskeleton organization
i	0000776	cellular_component	kinetochore
i	0001673	cellular_component	male germ cell nucleus
i	0005515	molecular_function	protein binding
i	0005524	molecular_function	ATP binding
i	0005770	cellular_component	late endosome
i	0005813	cellular_component	centrosome
i	0005829	cellular_component	cytosol
i	0005856	cellular_component	cytoskeleton
i	0005868	cellular_component	cytoplasmic dynein complex
i	0005874	cellular_component	microtubule
i	0007018	biological_process	microtubule-based movement
i	0016020	cellular_component	membrane
i	0030286	cellular_component	dynein complex
i	0032388	biological_process	positive regulation of intracellular transport
i	0042802	molecular_function	identical protein binding
i	0045504	molecular_function	dynein heavy chain binding
i	1990090	biological_process	cellular response to nerve growth factor stimulus
j	0000166	molecular_function	nucleotide binding
j	0000226	biological_process	microtubule cytoskeleton organization
j	0000776	cellular_component	kinetochore
j	0001673	cellular_component	male germ cell nucleus
j	0005515	molecular_function	protein binding
j	0005524	molecular_function	ATP binding
j	0005770	cellular_component	late endosome
j	0005813	cellular_component	centrosome
j	0005829	cellular_component	cytosol
j	0005856	cellular_component	cytoskeleton
j	0005868	cellular_component	cytoplasmic dynein complex
j	0005874	cellular_component	microtubule
j	0007018	biological_process	microtubule-based movement
j	0016020	cellular_component	membrane
j	0030286	cellular_component	dynein complex
j	0032388	biological_process	positive regulation of intracellular transport
j	0042802	molecular_function	identical protein binding
j	0045504	molecular_function	dynein heavy chain binding
j	1990090	biological_process	cellular response to nerve growth factor stimulus
k	0003777	molecular_function	microtubule motor activity
k	0005515	molecular_function	protein binding
k	0005737	cellular_component	cytoplasm
k	0005813	cellular_component	centrosome
k	0005856	cellular_component	cytoskeleton
k	0005868	cellular_component	cytoplasmic dynein complex
k	0005874	cellular_component	microtubule
k	0005929	cellular_component	cilium
k	0007018	biological_process	microtubule-based movement
k	0007632	biological_process	visual behavior
k	0016020	cellular_component	membrane
k	0030286	cellular_component	dynein complex
k	0032388	biological_process	positive regulation of intracellular transport
k	0035721	biological_process	intraciliary retrograde transport
k	0042802	molecular_function	identical protein binding
k	0045505	molecular_function	dynein intermediate chain binding
k	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
k	0097542	cellular_component	ciliary tip
l	0003777	molecular_function	microtubule motor activity
l	0005515	molecular_function	protein binding
l	0005737	cellular_component	cytoplasm
l	0005813	cellular_component	centrosome
l	0005856	cellular_component	cytoskeleton
l	0005868	cellular_component	cytoplasmic dynein complex
l	0005874	cellular_component	microtubule
l	0005929	cellular_component	cilium
l	0007018	biological_process	microtubule-based movement
l	0007632	biological_process	visual behavior
l	0016020	cellular_component	membrane
l	0030286	cellular_component	dynein complex
l	0032388	biological_process	positive regulation of intracellular transport
l	0035721	biological_process	intraciliary retrograde transport
l	0042802	molecular_function	identical protein binding
l	0045505	molecular_function	dynein intermediate chain binding
l	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
l	0097542	cellular_component	ciliary tip
m	0007018	biological_process	microtubule-based movement
m	0030286	cellular_component	dynein complex
m	0045505	molecular_function	dynein intermediate chain binding
m	0051959	molecular_function	dynein light intermediate chain binding
n	0007018	biological_process	microtubule-based movement
n	0030286	cellular_component	dynein complex
n	0045505	molecular_function	dynein intermediate chain binding
n	0051959	molecular_function	dynein light intermediate chain binding
o	0001673	cellular_component	male germ cell nucleus
o	0003777	molecular_function	microtubule motor activity
o	0005515	molecular_function	protein binding
o	0005737	cellular_component	cytoplasm
o	0005813	cellular_component	centrosome
o	0005829	cellular_component	cytosol
o	0005856	cellular_component	cytoskeleton
o	0005868	cellular_component	cytoplasmic dynein complex
o	0005874	cellular_component	microtubule
o	0007018	biological_process	microtubule-based movement
o	0010970	biological_process	transport along microtubule
o	0030286	cellular_component	dynein complex
o	0031982	cellular_component	vesicle
o	0032388	biological_process	positive regulation of intracellular transport
o	0045503	molecular_function	dynein light chain binding
o	0045504	molecular_function	dynein heavy chain binding
o	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
p	0001673	cellular_component	male germ cell nucleus
p	0003777	molecular_function	microtubule motor activity
p	0005515	molecular_function	protein binding
p	0005737	cellular_component	cytoplasm
p	0005813	cellular_component	centrosome
p	0005829	cellular_component	cytosol
p	0005856	cellular_component	cytoskeleton
p	0005868	cellular_component	cytoplasmic dynein complex
p	0005874	cellular_component	microtubule
p	0007018	biological_process	microtubule-based movement
p	0010970	biological_process	transport along microtubule
p	0030286	cellular_component	dynein complex
p	0031982	cellular_component	vesicle
p	0032388	biological_process	positive regulation of intracellular transport
p	0045503	molecular_function	dynein light chain binding
p	0045504	molecular_function	dynein heavy chain binding
p	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
q	0000166	molecular_function	nucleotide binding
q	0000226	biological_process	microtubule cytoskeleton organization
q	0000776	cellular_component	kinetochore
q	0001673	cellular_component	male germ cell nucleus
q	0005515	molecular_function	protein binding
q	0005524	molecular_function	ATP binding
q	0005770	cellular_component	late endosome
q	0005813	cellular_component	centrosome
q	0005829	cellular_component	cytosol
q	0005856	cellular_component	cytoskeleton
q	0005868	cellular_component	cytoplasmic dynein complex
q	0005874	cellular_component	microtubule
q	0007018	biological_process	microtubule-based movement
q	0016020	cellular_component	membrane
q	0030286	cellular_component	dynein complex
q	0032388	biological_process	positive regulation of intracellular transport
q	0042802	molecular_function	identical protein binding
q	0045504	molecular_function	dynein heavy chain binding
q	1990090	biological_process	cellular response to nerve growth factor stimulus
r	0000166	molecular_function	nucleotide binding
r	0000226	biological_process	microtubule cytoskeleton organization
r	0000776	cellular_component	kinetochore
r	0001673	cellular_component	male germ cell nucleus
r	0005515	molecular_function	protein binding
r	0005524	molecular_function	ATP binding
r	0005770	cellular_component	late endosome
r	0005813	cellular_component	centrosome
r	0005829	cellular_component	cytosol
r	0005856	cellular_component	cytoskeleton
r	0005868	cellular_component	cytoplasmic dynein complex
r	0005874	cellular_component	microtubule
r	0007018	biological_process	microtubule-based movement
r	0016020	cellular_component	membrane
r	0030286	cellular_component	dynein complex
r	0032388	biological_process	positive regulation of intracellular transport
r	0042802	molecular_function	identical protein binding
r	0045504	molecular_function	dynein heavy chain binding
r	1990090	biological_process	cellular response to nerve growth factor stimulus
s	0003777	molecular_function	microtubule motor activity
s	0005515	molecular_function	protein binding
s	0005737	cellular_component	cytoplasm
s	0005813	cellular_component	centrosome
s	0005856	cellular_component	cytoskeleton
s	0005868	cellular_component	cytoplasmic dynein complex
s	0005874	cellular_component	microtubule
s	0005929	cellular_component	cilium
s	0007018	biological_process	microtubule-based movement
s	0007632	biological_process	visual behavior
s	0016020	cellular_component	membrane
s	0030286	cellular_component	dynein complex
s	0032388	biological_process	positive regulation of intracellular transport
s	0035721	biological_process	intraciliary retrograde transport
s	0042802	molecular_function	identical protein binding
s	0045505	molecular_function	dynein intermediate chain binding
s	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
s	0097542	cellular_component	ciliary tip
t	0003777	molecular_function	microtubule motor activity
t	0005515	molecular_function	protein binding
t	0005737	cellular_component	cytoplasm
t	0005813	cellular_component	centrosome
t	0005856	cellular_component	cytoskeleton
t	0005868	cellular_component	cytoplasmic dynein complex
t	0005874	cellular_component	microtubule
t	0005929	cellular_component	cilium
t	0007018	biological_process	microtubule-based movement
t	0007632	biological_process	visual behavior
t	0016020	cellular_component	membrane
t	0030286	cellular_component	dynein complex
t	0032388	biological_process	positive regulation of intracellular transport
t	0035721	biological_process	intraciliary retrograde transport
t	0042802	molecular_function	identical protein binding
t	0045505	molecular_function	dynein intermediate chain binding
t	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
t	0097542	cellular_component	ciliary tip

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ADP A 800

Chain	Residue
A	GLY17
A	GLU219
A	GLY302
A	GLY303
A	SER304
A	PHE307
A	SER18
A	VAL20
A	LYS22
A	GLN142
A	SER160
A	GLY161
A	ASP162
A	LYS218

---

site_id	AC2
Number of Residues	12
Details	binding site for residue ADP B 800

Chain	Residue
B	ASN16
B	GLY17
B	SER18
B	VAL20
B	LYS22
B	GLY161
B	ASP162
B	LYS218
B	GLU219
B	GLY303
B	SER304
B	PHE307

---

site_id	AC3
Number of Residues	11
Details	binding site for residue ADP C 800

Chain	Residue
C	GLY17
C	SER18
C	GLY19
C	VAL20
C	LYS22
C	GLY161
C	ASP162
C	LYS218
C	GLU219
C	GLY303
C	PHE307

---

site_id	AC4
Number of Residues	16
Details	binding site for residue ADP D 800

Chain	Residue
D	GLY17
D	SER18
D	GLY19
D	VAL20
D	LYS22
D	SER160
D	GLY161
D	ASP162
D	LYS218
D	GLU219
D	GLY302
D	GLY303
D	SER304
D	LEU306
D	PHE307
D	LEU337

---

site_id	AC5
Number of Residues	14
Details	binding site for residue ADP E 800

Chain	Residue
E	GLY17
E	SER18
E	GLY19
E	VAL20
E	LYS22
E	GLY161
E	ASP162
E	LYS218
E	GLU219
E	GLY302
E	GLY303
E	SER304
E	LEU306
E	PHE307

---

site_id	AC6
Number of Residues	14
Details	binding site for residue ADP F 800

Chain	Residue
F	GLY17
F	VAL20
F	LYS22
F	SER160
F	GLY161
F	ASP162
F	LYS215
F	LYS218
F	GLU219
F	GLY302
F	GLY303
F	SER304
F	LEU306
F	LEU337

---

site_id	AC7
Number of Residues	16
Details	binding site for residue ADP G 800

Chain	Residue
G	GLY17
G	SER18
G	GLY19
G	VAL20
G	LYS22
G	GLY161
G	ASP162
G	LYS215
G	LYS218
G	GLU219
G	GLY302
G	GLY303
G	SER304
G	LEU306
G	PHE307
G	LEU337

---

site_id	AC8
Number of Residues	16
Details	binding site for residue ATP H 401

Chain	Residue
H	SER14
H	GLY15
H	MET16
H	LYS18
H	GLN137
H	GLY156
H	ASP157
H	ARG210
H	LYS213
H	GLU214
H	GLY302
H	THR303
H	MET305
H	TYR306
H	ASP11
H	GLY13

---

site_id	AC9
Number of Residues	14
Details	binding site for residue ADP I 800

Chain	Residue
I	GLY17
I	SER18
I	GLY19
I	VAL20
I	GLY161
I	ASP162
I	LYS215
I	LYS218
I	GLU219
I	GLY302
I	GLY303
I	SER304
I	LEU306
I	PHE307

---

site_id	AD1
Number of Residues	12
Details	binding site for residue ADP J 800

Chain	Residue
J	GLY21
J	GLU22
J	ALA23
J	PHE24
J	LYS26
J	GLY142
J	TYR143
J	LYS211
J	GLY308
J	THR309
J	MET311
J	ASN351

---

site_id	AD2
Number of Residues	9
Details	binding site for Di-peptide ASP n 558 and GLU n 561

Chain	Residue
n	ASP554
n	GLU555
n	ARG556
n	ILE557
n	ARG559
n	VAL560
n	THR562
n	ARG563
n	ILE564

---

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
L	CYS62-ASP67

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
H	TRP356-GLU364
A	TRP357-GLU365

---

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
K	VAL196-VAL204

---

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
K	LYS256-ARG266

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
H	LEU104-ARG116
A	LEU109-ARG121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P47756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P47756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Motif: {"description":"CC1 box","evidences":[{"source":"PubMed","id":"36071160","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q13561","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q13561","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q13561","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	604
Details	Region: {"description":"Interaction with DYNC1LI2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	268
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	196
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	160
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	164
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	160
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	180
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	160
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	156
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---