Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6F09

Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000122	biological_process	negative regulation of transcription by RNA polymerase II
P	0001525	biological_process	angiogenesis
P	0003016	biological_process	respiratory system process
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005925	cellular_component	focal adhesion
P	0006468	biological_process	protein phosphorylation
P	0006605	biological_process	protein targeting
P	0007165	biological_process	signal transduction
P	0008039	biological_process	synaptic target recognition
P	0008104	biological_process	protein localization
P	0019901	molecular_function	protein kinase binding
P	0019904	molecular_function	protein domain specific binding
P	0030324	biological_process	lung development
P	0031625	molecular_function	ubiquitin protein ligase binding
P	0031647	biological_process	regulation of protein stability
P	0031982	cellular_component	vesicle
P	0035148	biological_process	tube formation
P	0042149	biological_process	cellular response to glucose starvation
P	0042470	cellular_component	melanosome
P	0042802	molecular_function	identical protein binding
P	0043066	biological_process	negative regulation of apoptotic process
P	0043067	biological_process	regulation of programmed cell death
P	0044325	molecular_function	transmembrane transporter binding
P	0045296	molecular_function	cadherin binding
P	0045824	biological_process	negative regulation of innate immune response
P	0050815	molecular_function	phosphoserine residue binding
P	0051683	biological_process	establishment of Golgi localization
P	0070062	cellular_component	extracellular exosome
P	0070371	biological_process	ERK1 and ERK2 cascade
P	0070372	biological_process	regulation of ERK1 and ERK2 cascade
P	0072562	cellular_component	blood microparticle
P	0090128	biological_process	regulation of synapse maturation
P	0090168	biological_process	Golgi reassembly
P	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
P	0098978	cellular_component	glutamatergic synapse
P	0140297	molecular_function	DNA-binding transcription factor binding
P	0140311	molecular_function	protein sequestering activity
P	1900181	biological_process	negative regulation of protein localization to nucleus
P	1904262	biological_process	negative regulation of TORC1 signaling
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0001525	biological_process	angiogenesis
Q	0003016	biological_process	respiratory system process
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005615	cellular_component	extracellular space
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005925	cellular_component	focal adhesion
Q	0006468	biological_process	protein phosphorylation
Q	0006605	biological_process	protein targeting
Q	0007165	biological_process	signal transduction
Q	0008039	biological_process	synaptic target recognition
Q	0008104	biological_process	protein localization
Q	0019901	molecular_function	protein kinase binding
Q	0019904	molecular_function	protein domain specific binding
Q	0030324	biological_process	lung development
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0031647	biological_process	regulation of protein stability
Q	0031982	cellular_component	vesicle
Q	0035148	biological_process	tube formation
Q	0042149	biological_process	cellular response to glucose starvation
Q	0042470	cellular_component	melanosome
Q	0042802	molecular_function	identical protein binding
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043067	biological_process	regulation of programmed cell death
Q	0044325	molecular_function	transmembrane transporter binding
Q	0045296	molecular_function	cadherin binding
Q	0045824	biological_process	negative regulation of innate immune response
Q	0050815	molecular_function	phosphoserine residue binding
Q	0051683	biological_process	establishment of Golgi localization
Q	0070062	cellular_component	extracellular exosome
Q	0070371	biological_process	ERK1 and ERK2 cascade
Q	0070372	biological_process	regulation of ERK1 and ERK2 cascade
Q	0072562	cellular_component	blood microparticle
Q	0090128	biological_process	regulation of synapse maturation
Q	0090168	biological_process	Golgi reassembly
Q	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
Q	0098978	cellular_component	glutamatergic synapse
Q	0140297	molecular_function	DNA-binding transcription factor binding
Q	0140311	molecular_function	protein sequestering activity
Q	1900181	biological_process	negative regulation of protein localization to nucleus
Q	1904262	biological_process	negative regulation of TORC1 signaling
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0001525	biological_process	angiogenesis
R	0003016	biological_process	respiratory system process
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005615	cellular_component	extracellular space
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005925	cellular_component	focal adhesion
R	0006468	biological_process	protein phosphorylation
R	0006605	biological_process	protein targeting
R	0007165	biological_process	signal transduction
R	0008039	biological_process	synaptic target recognition
R	0008104	biological_process	protein localization
R	0019901	molecular_function	protein kinase binding
R	0019904	molecular_function	protein domain specific binding
R	0030324	biological_process	lung development
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0031647	biological_process	regulation of protein stability
R	0031982	cellular_component	vesicle
R	0035148	biological_process	tube formation
R	0042149	biological_process	cellular response to glucose starvation
R	0042470	cellular_component	melanosome
R	0042802	molecular_function	identical protein binding
R	0043066	biological_process	negative regulation of apoptotic process
R	0043067	biological_process	regulation of programmed cell death
R	0044325	molecular_function	transmembrane transporter binding
R	0045296	molecular_function	cadherin binding
R	0045824	biological_process	negative regulation of innate immune response
R	0050815	molecular_function	phosphoserine residue binding
R	0051683	biological_process	establishment of Golgi localization
R	0070062	cellular_component	extracellular exosome
R	0070371	biological_process	ERK1 and ERK2 cascade
R	0070372	biological_process	regulation of ERK1 and ERK2 cascade
R	0072562	cellular_component	blood microparticle
R	0090128	biological_process	regulation of synapse maturation
R	0090168	biological_process	Golgi reassembly
R	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
R	0098978	cellular_component	glutamatergic synapse
R	0140297	molecular_function	DNA-binding transcription factor binding
R	0140311	molecular_function	protein sequestering activity
R	1900181	biological_process	negative regulation of protein localization to nucleus
R	1904262	biological_process	negative regulation of TORC1 signaling
S	0000122	biological_process	negative regulation of transcription by RNA polymerase II
S	0001525	biological_process	angiogenesis
S	0003016	biological_process	respiratory system process
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005615	cellular_component	extracellular space
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005925	cellular_component	focal adhesion
S	0006468	biological_process	protein phosphorylation
S	0006605	biological_process	protein targeting
S	0007165	biological_process	signal transduction
S	0008039	biological_process	synaptic target recognition
S	0008104	biological_process	protein localization
S	0019901	molecular_function	protein kinase binding
S	0019904	molecular_function	protein domain specific binding
S	0030324	biological_process	lung development
S	0031625	molecular_function	ubiquitin protein ligase binding
S	0031647	biological_process	regulation of protein stability
S	0031982	cellular_component	vesicle
S	0035148	biological_process	tube formation
S	0042149	biological_process	cellular response to glucose starvation
S	0042470	cellular_component	melanosome
S	0042802	molecular_function	identical protein binding
S	0043066	biological_process	negative regulation of apoptotic process
S	0043067	biological_process	regulation of programmed cell death
S	0044325	molecular_function	transmembrane transporter binding
S	0045296	molecular_function	cadherin binding
S	0045824	biological_process	negative regulation of innate immune response
S	0050815	molecular_function	phosphoserine residue binding
S	0051683	biological_process	establishment of Golgi localization
S	0070062	cellular_component	extracellular exosome
S	0070371	biological_process	ERK1 and ERK2 cascade
S	0070372	biological_process	regulation of ERK1 and ERK2 cascade
S	0072562	cellular_component	blood microparticle
S	0090128	biological_process	regulation of synapse maturation
S	0090168	biological_process	Golgi reassembly
S	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
S	0098978	cellular_component	glutamatergic synapse
S	0140297	molecular_function	DNA-binding transcription factor binding
S	0140311	molecular_function	protein sequestering activity
S	1900181	biological_process	negative regulation of protein localization to nucleus
S	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
P	ARG41-VAL51

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
P	TYR211-SER230

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SEP718
B	SEP718
C	SEP718
D	SEP718
R	ARG56
R	ARG127
S	ARG56
S	ARG127

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	SER719
B	SER719
C	SER719
D	SER719

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
P	LYS3
P	LYS68
Q	LYS3
Q	LYS68
R	LYS3
R	LYS68
S	LYS3
S	LYS68

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKB/AKT1 => ECO:0000269\|PubMed:11956222, ECO:0000269\|PubMed:12865427, ECO:0000269\|PubMed:15883165, ECO:0000269\|PubMed:16376338

Chain	Residue	Details
P	SER58
Q	SER58
R	SER58
S	SER58

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269\|PubMed:15071501, ECO:0000269\|PubMed:15696159

Chain	Residue	Details
P	SER184
Q	SER184
R	SER184
S	SER184

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
P	SER207
Q	SER207
R	SER207
S	SER207

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P63102

Chain	Residue	Details
P	SER210
Q	SER210
R	SER210
S	SER210

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)