6F00
Crystal Structure of human tRNA dihydrouridine synthase (20) dsRBD E423A mutant
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| A | ARG362 |
| B | ALA384 |
| B | GLN385 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | GLU389 |
| B | THR390 |
| B | LYS419 |
| B | HOH616 |
| C | ALA356 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | GLN367 |
| C | ARG379 |
| B | ALA366 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| B | ARG432 |
| B | HOH611 |
| B | HOH620 |
| B | HOH624 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | GLU389 |
| A | THR390 |
| A | LYS419 |
| A | HOH602 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | ALA384 |
| A | GLN385 |
| C | ARG362 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | ARG361 |
| A | ALA366 |
| A | GLN367 |
| B | ARG379 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | LYS354 |
| A | SER400 |
| A | GLN411 |
| A | SER412 |
| A | THR413 |
| A | LEU414 |
| A | TRP415 |
| A | HOH606 |
| B | HOH630 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | GLU438 |
| A | ARG440 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | THR369 |
| A | LYS371 |
| A | MET372 |
| A | GLN424 |
| C | GLN367 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 501 |
| Chain | Residue |
| C | THR390 |
| C | LYS419 |
| C | HOH606 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 502 |
| Chain | Residue |
| B | ARG362 |
| C | ALA384 |
| C | GLN385 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 503 |
| Chain | Residue |
| A | LEU375 |
| A | ARG379 |
| C | ALA366 |
| C | GLN367 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | LYS354 |
| C | SER400 |
| C | SER412 |
| C | THR413 |
| C | LEU414 |
| C | TRP415 |
| C | HOH605 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 505 |
| Chain | Residue |
| C | GLU438 |
| C | ARG440 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 201 |
| Details | Domain: {"description":"DRBM","evidences":[{"source":"PubMed","id":"26429968","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Region: {"description":"Interaction with tRNA","evidences":[{"source":"PubMed","id":"30605527","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38680565","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
