6EZC
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K Q305K double mutant
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue FMN A 401 |
| Chain | Residue |
| A | ALA17 |
| A | ASN214 |
| A | GLY215 |
| A | GLY216 |
| A | SER217 |
| A | ALA242 |
| A | ARG243 |
| A | GOL406 |
| A | HOH519 |
| A | HOH574 |
| A | HOH591 |
| A | PRO18 |
| A | MET19 |
| A | VAL20 |
| A | GLU43 |
| A | GLN87 |
| A | ASN113 |
| A | LYS155 |
| A | HIS183 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | SER91 |
| A | ARG95 |
| A | GLY315 |
| A | LEU316 |
| A | GLY317 |
| A | ALA318 |
| A | HOH564 |
| A | HOH581 |
| A | HOH676 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | ARG21 |
| A | HIS277 |
| A | THR279 |
| A | ASN280 |
| A | PGE408 |
| A | HOH636 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | ASN82 |
| A | ARG83 |
| A | HOH571 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 405 |
| Chain | Residue |
| A | GLY115 |
| A | LYS155 |
| A | ARG157 |
| A | HIS183 |
| A | HOH582 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | GLU43 |
| A | ASN113 |
| A | FMN401 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 407 |
| Chain | Residue |
| A | ARG149 |
| A | ARG150 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue PGE A 408 |
| Chain | Residue |
| A | THR24 |
| A | GLU42 |
| A | VAL72 |
| A | ARG75 |
| A | ASN276 |
| A | HIS277 |
| A | ASN280 |
| A | SO4403 |
| A | HOH520 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 409 |
| Chain | Residue |
| A | SER306 |
| A | ARG308 |
| A | HOH547 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 410 |
| Chain | Residue |
| A | ARG299 |
| A | HOH641 |
Functional Information from PROSITE/UniProt
| site_id | PS01136 |
| Number of Residues | 19 |
| Details | UPF0034 Uncharacterized protein family UPF0034 signature. IDVNmGCPkqy.Stkggm.GA |
| Chain | Residue | Details |
| A | ILE110-ALA128 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26143927","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26429968","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XP7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26429968","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WFS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
