6EZA
Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008033 | biological_process | tRNA processing |
| A | 0017150 | molecular_function | tRNA dihydrouridine synthase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0008033 | biological_process | tRNA processing |
| B | 0017150 | molecular_function | tRNA dihydrouridine synthase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue FMN A 401 |
| Chain | Residue |
| A | ALA17 |
| A | ASN214 |
| A | GLY215 |
| A | GLY216 |
| A | SER217 |
| A | ALA242 |
| A | ARG243 |
| A | HOH541 |
| A | HOH558 |
| A | HOH590 |
| A | PRO18 |
| A | MET19 |
| A | VAL20 |
| A | GLU43 |
| A | GLN87 |
| A | ASN113 |
| A | LYS155 |
| A | HIS183 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG21 |
| A | HIS277 |
| A | THR279 |
| A | ASN280 |
| A | HOH583 |
| A | HOH609 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | ASN82 |
| A | ARG83 |
| A | HOH513 |
| A | HOH546 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | ARG149 |
| A | ARG150 |
| A | HOH524 |
| A | HOH549 |
| B | ARG149 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 405 |
| Chain | Residue |
| A | GLY115 |
| A | LYS155 |
| A | ARG157 |
| A | HIS183 |
| A | HOH573 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | SER91 |
| A | ARG95 |
| A | HOH614 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 407 |
| Chain | Residue |
| A | ARG308 |
| A | HOH533 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| A | VAL55 |
| A | VAL56 |
| B | ARG54 |
| B | VAL55 |
| B | VAL56 |
| B | HOH575 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | SER91 |
| B | ARG95 |
| B | HOH579 |
| B | HOH615 |
| site_id | AD1 |
| Number of Residues | 19 |
| Details | binding site for residue FMN B 403 |
| Chain | Residue |
| B | ALA17 |
| B | PRO18 |
| B | MET19 |
| B | VAL20 |
| B | GLU43 |
| B | GLN87 |
| B | ASN113 |
| B | LYS155 |
| B | HIS183 |
| B | ASN214 |
| B | GLY215 |
| B | GLY216 |
| B | SER217 |
| B | ALA242 |
| B | ARG243 |
| B | GOL407 |
| B | HOH508 |
| B | HOH548 |
| B | HOH574 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | ARG21 |
| B | THR279 |
| B | ASN280 |
| B | HOH552 |
| B | HOH594 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | ASN82 |
| B | ARG83 |
| B | HOH513 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| A | ARG149 |
| B | ARG149 |
| B | ARG150 |
| B | HOH553 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 407 |
| Chain | Residue |
| B | ARG157 |
| B | FMN403 |
| B | HOH508 |
| B | HOH539 |
Functional Information from PROSITE/UniProt
| site_id | PS01136 |
| Number of Residues | 19 |
| Details | UPF0034 Uncharacterized protein family UPF0034 signature. IDVNmGCPkqy.Stkggm.GA |
| Chain | Residue | Details |
| A | ILE110-ALA128 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"38680565","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26143927","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26429968","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XP7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26429968","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WFS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
