6ETW
Crystal structure of KDM4D with tetrazolhydrazide compound 3
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ASN128 |
| A | LYS186 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ASN128 |
| A | HOH692 |
| A | HOH783 |
| A | ARG123 |
| A | LYS124 |
| A | LYS127 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LYS150 |
| A | GLN151 |
| A | TRP152 |
| A | ASN153 |
| A | HIS156 |
| A | HOH603 |
| A | HOH644 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | PRO251 |
| A | THR252 |
| A | LYS255 |
| A | ARG263 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLU27 |
| A | TYR37 |
| A | HOH598 |
| A | HOH802 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | ARG60 |
| A | GLU61 |
| A | THR62 |
| A | ASN65 |
| A | HOH524 |
| A | HOH537 |
| A | HOH538 |
| A | HOH782 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue SO4 A 408 |
| Chain | Residue |
| A | MET19 |
| A | ILE20 |
| A | LYS255 |
| A | HOH562 |
| A | HOH713 |
| A | HOH737 |
| A | HOH771 |
| A | HOH850 |
| A | HOH850 |
| A | HOH857 |
| A | HOH905 |
| A | HOH914 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 409 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | BX5410 |
| A | HOH631 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue BX5 A 410 |
| Chain | Residue |
| A | TYR181 |
| A | PHE189 |
| A | HIS192 |
| A | GLU194 |
| A | SER200 |
| A | ASN202 |
| A | LYS210 |
| A | HIS280 |
| A | NI409 |
| A | HOH631 |
| A | HOH784 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 411 |
| Chain | Residue |
| A | ARG102 |
| A | HIS103 |
| A | ASN106 |
| A | HOH609 |
| A | HOH667 |
| A | HOH817 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
