5F5C
Crystal Structure of human JMJD2D complexed with KDOPP7
Summary for 5F5C
Entry DOI | 10.2210/pdb5f5c/pdb |
Descriptor | Lysine-specific demethylase 4D, ZINC ION, NICKEL (II) ION, ... (7 entities in total) |
Functional Keywords | double-stranded beta helix, demethylase, oxygenase, oxidoreductase, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q6B0I6 |
Total number of polymer chains | 1 |
Total formula weight | 41006.28 |
Authors | Krojer, T.,Vollmar, M.,Crawley, L.,Bradley, A.R.,Szykowska, A.,Ruda, G.F.,Yang, H.,Burgess-Brown, N.,Brennan, P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Oppermann, U.,von Delft, F.,Structural Genomics Consortium (SGC) (deposition date: 2015-12-04, release date: 2015-12-30, Last modification date: 2024-01-10) |
Primary citation | Bavetsias, V.,Lanigan, R.M.,Ruda, G.F.,Atrash, B.,McLaughlin, M.G.,Tumber, A.,Mok, N.Y.,Le Bihan, Y.V.,Dempster, S.,Boxall, K.J.,Jeganathan, F.,Hatch, S.B.,Savitsky, P.,Velupillai, S.,Krojer, T.,England, K.S.,Sejberg, J.,Thai, C.,Donovan, A.,Pal, A.,Scozzafava, G.,Bennett, J.M.,Kawamura, A.,Johansson, C.,Szykowska, A.,Gileadi, C.,Burgess-Brown, N.A.,von Delft, F.,Oppermann, U.,Walters, Z.,Shipley, J.,Raynaud, F.I.,Westaway, S.M.,Prinjha, R.K.,Fedorov, O.,Burke, R.,Schofield, C.J.,Westwood, I.M.,Bountra, C.,Muller, S.,van Montfort, R.L.,Brennan, P.E.,Blagg, J. 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59:1388-1409, 2016 Cited by PubMed: 26741168DOI: 10.1021/acs.jmedchem.5b01635 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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