5F5C
Crystal Structure of human JMJD2D complexed with KDOPP7
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 402 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | 5V3411 |
| A | HOH522 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ALA83 |
| A | GLY84 |
| A | TRP126 |
| A | SER250 |
| A | VAL253 |
| A | HOH541 |
| A | HOH645 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LYS150 |
| A | GLN151 |
| A | TRP152 |
| A | ASN153 |
| A | HIS156 |
| A | HOH557 |
| A | HOH692 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | PRO251 |
| A | THR252 |
| A | LYS255 |
| A | ARG263 |
| A | HOH740 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | PHE118 |
| A | GLU122 |
| A | ARG263 |
| A | ILE264 |
| A | THR265 |
| A | HOH509 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | ARG60 |
| A | GLU61 |
| A | THR62 |
| A | ASN65 |
| A | HOH582 |
| A | HOH594 |
| A | HOH669 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 408 |
| Chain | Residue |
| A | ARG123 |
| A | LYS124 |
| A | LYS127 |
| A | ASN128 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 409 |
| Chain | Residue |
| A | PRO113 |
| A | LYS124 |
| A | ASN128 |
| A | TRP185 |
| A | LYS186 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | ALA105 |
| A | ASN106 |
| A | GLN111 |
| A | THR112 |
| A | GLY286 |
| A | PHE287 |
| A | HOH513 |
| A | HOH577 |
| A | HOH837 |
| site_id | AD2 |
| Number of Residues | 13 |
| Details | binding site for residue 5V3 A 411 |
| Chain | Residue |
| A | TYR136 |
| A | TYR179 |
| A | TYR181 |
| A | PHE189 |
| A | HIS192 |
| A | GLU194 |
| A | SER200 |
| A | LYS210 |
| A | TRP212 |
| A | HIS280 |
| A | ASN294 |
| A | NI402 |
| A | HOH522 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
