6ETS

Crystal structure of KDM4D with tetrazolhydrazide compound 1

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS238
A	HIS244
A	CYS310
A	CYS312

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NI A 402

Chain	Residue
A	HIS192
A	GLU194
A	HIS280
A	I1L416
A	HOH738

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NA A 403

Chain	Residue
A	ASN17
A	ASN262
A	HOH630
A	HOH649
A	HOH829
A	HOH829

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 404

Chain	Residue
A	ARG123
A	LYS124
A	LYS127
A	ASN128
A	HOH726

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 405

Chain	Residue
A	LYS150
A	GLN151
A	TRP152
A	ASN153
A	HIS156
A	HOH657
A	HOH680

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 406

Chain	Residue
A	THR252
A	LYS255
A	ARG263
A	EDO409

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 407

Chain	Residue
A	PHE118
A	GLU122
A	ARG263
A	THR265
A	HOH629

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 408

Chain	Residue
A	LYS109
A	GLN111
A	PRO113
A	ASN132
A	TRP185
A	LYS186
A	HOH514

---

site_id	AC9
Number of Residues	7
Details	binding site for residue EDO A 409

Chain	Residue
A	GLU122
A	ARG123
A	TRP126
A	EDO406
A	HOH572
A	HOH603
A	HOH623

---

site_id	AD1
Number of Residues	9
Details	binding site for residue EDO A 410

Chain	Residue
A	TYR179
A	TYR181
A	GLU194
A	SER200
A	ALA292
A	ASN294
A	I1L416
A	HOH738
A	HOH808

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO A 411

Chain	Residue
A	PHE31
A	ASP32
A	GLY158
A	PHE295
A	ALA296
A	HOH507

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 412

Chain	Residue
A	GLU27
A	TYR37
A	HOH521
A	HOH864

---

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 A 413

Chain	Residue
A	ARG60
A	THR62
A	ASP64
A	ASN65
A	HOH578
A	HOH597
A	HOH801

---

site_id	AD5
Number of Residues	12
Details	binding site for residue SO4 A 414

Chain	Residue
A	MET19
A	ILE20
A	LYS255
A	HOH541
A	HOH665
A	HOH770
A	HOH799
A	HOH812
A	HOH856
A	HOH894
A	HOH919
A	HOH935

---

site_id	AD6
Number of Residues	6
Details	binding site for residue SO4 A 415

Chain	Residue
A	ARG102
A	HIS103
A	ASN106
A	HOH504
A	HOH513
A	HOH565

---

site_id	AD7
Number of Residues	15
Details	binding site for residue I1L A 416

Chain	Residue
A	ASN202
A	LYS210
A	TRP212
A	HIS280
A	NI402
A	EDO410
A	HOH538
A	HOH642
A	HOH738
A	HOH817
A	TYR136
A	PHE189
A	HIS192
A	GLU194
A	SER200

---

site_id	AD8
Number of Residues	2
Details	binding site for residue CL A 417

Chain	Residue
A	ASN128
A	LYS186

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---