6ERH

Complex of XLF and heterodimer Ku bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0005634	cellular_component	nucleus
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0042162	molecular_function	telomeric DNA binding
A	0043564	cellular_component	Ku70:Ku80 complex
B	0000723	biological_process	telomere maintenance
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0005634	cellular_component	nucleus
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0042162	molecular_function	telomeric DNA binding
B	0043564	cellular_component	Ku70:Ku80 complex
C	0000723	biological_process	telomere maintenance
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003684	molecular_function	damaged DNA binding
C	0005634	cellular_component	nucleus
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0042162	molecular_function	telomeric DNA binding
C	0043564	cellular_component	Ku70:Ku80 complex
D	0000723	biological_process	telomere maintenance
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0003684	molecular_function	damaged DNA binding
D	0005634	cellular_component	nucleus
D	0006303	biological_process	double-strand break repair via nonhomologous end joining
D	0006310	biological_process	DNA recombination
D	0042162	molecular_function	telomeric DNA binding
D	0043564	cellular_component	Ku70:Ku80 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 601

Chain	Residue
A	HIS359
A	HIS360
B	LYS363
B	HIS411
B	TYR416

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 C 601

Chain	Residue
D	LYS413
D	TYR416
C	HIS359
C	HIS360
D	LYS363
D	HIS411

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	414
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	218
Details	Region: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	398
Details	Domain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	54
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---