6EHO
Dimer of the Sortilin Vps10p domain at low pH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001503 | biological_process | ossification |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005769 | cellular_component | early endosome |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005905 | cellular_component | clathrin-coated pit |
| A | 0006895 | biological_process | Golgi to endosome transport |
| A | 0006897 | biological_process | endocytosis |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007218 | biological_process | neuropeptide signaling pathway |
| A | 0008333 | biological_process | endosome to lysosome transport |
| A | 0008625 | biological_process | extrinsic apoptotic signaling pathway via death domain receptors |
| A | 0009986 | cellular_component | cell surface |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010465 | molecular_function | nerve growth factor receptor activity |
| A | 0010468 | biological_process | regulation of gene expression |
| A | 0014902 | biological_process | myotube differentiation |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016050 | biological_process | vesicle organization |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030136 | cellular_component | clathrin-coated vesicle |
| A | 0030140 | cellular_component | trans-Golgi network transport vesicle |
| A | 0030154 | biological_process | cell differentiation |
| A | 0030379 | molecular_function | neurotensin receptor activity, non-G protein-coupled |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032509 | biological_process | endosome transport via multivesicular body sorting pathway |
| A | 0032580 | cellular_component | Golgi cisterna membrane |
| A | 0032868 | biological_process | response to insulin |
| A | 0038180 | biological_process | nerve growth factor signaling pathway |
| A | 0048011 | biological_process | neurotrophin TRK receptor signaling pathway |
| A | 0048227 | biological_process | plasma membrane to endosome transport |
| A | 0048406 | molecular_function | nerve growth factor binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0090160 | biological_process | Golgi to lysosome transport |
| A | 0098708 | biological_process | D-glucose import across plasma membrane |
| A | 0099558 | biological_process | maintenance of synapse structure |
| A | 0150053 | cellular_component | cerebellar climbing fiber to Purkinje cell synapse |
| A | 1905394 | molecular_function | retromer complex binding |
Functional Information from PROSITE/UniProt
| site_id | PS00210 |
| Number of Residues | 9 |
| Details | HEMOCYANIN_2 Arthropod hemocyanins / insect LSPs signature 2. TftRDPiYF |
| Chain | Residue | Details |
| A | THR528-PHE536 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 11 |
| Details | Repeat: {"description":"BNR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 54 |
| Details | Region: {"description":"10CCa cysteine-knot","evidences":[{"source":"PROSITE-ProRule","id":"PRU01417","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19122660","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
