Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6EF1

Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0080129	biological_process	proteasome core complex assembly
D	0000502	cellular_component	proteasome complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034515	cellular_component	proteasome storage granule
D	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0005524	molecular_function	ATP binding
H	0016887	molecular_function	ATP hydrolysis activity
I	0005524	molecular_function	ATP binding
I	0016887	molecular_function	ATP hydrolysis activity
J	0005524	molecular_function	ATP binding
J	0016887	molecular_function	ATP hydrolysis activity
K	0005524	molecular_function	ATP binding
K	0016887	molecular_function	ATP hydrolysis activity
L	0005524	molecular_function	ATP binding
L	0016887	molecular_function	ATP hydrolysis activity
M	0005524	molecular_function	ATP binding
M	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ATP H 501

Chain	Residue
H	VAL211
H	GLY416
H	ALA417
H	ARG420
I	LEU310
I	ASP314
I	ARG340
H	GLY213
H	PRO252
H	GLY253
H	THR254
H	GLY255
H	LYS256
H	THR257
H	ILE388

site_id	AC2
Number of Residues	12
Details	binding site for residue ATP I 501

Chain	Residue
I	ILE184
I	THR227
I	GLY228
I	LYS229
I	THR230
I	LEU231
I	ILE361
I	ALA390
I	GLN393
J	LEU273
J	ASN277
J	ARG309

site_id	AC3
Number of Residues	12
Details	binding site for residue ATP J 501

Chain	Residue
J	MET149
J	VAL150
J	GLY151
J	PRO191
J	GLY192
J	THR193
J	GLY194
J	LYS195
J	THR196
J	GLY355
J	ALA356
K	ARG330

site_id	AC4
Number of Residues	13
Details	binding site for residue ATP K 501

Chain	Residue
K	ASP173
K	VAL174
K	PRO214
K	PRO215
K	GLY216
K	THR217
K	GLY218
K	LYS219
K	THR220
K	MET221
K	ILE352
K	GLY380
K	ALA381

site_id	AC5
Number of Residues	12
Details	binding site for residue ADP L 501

Chain	Residue
L	ILE183
L	GLY225
L	THR226
L	GLY227
L	LYS228
L	THR229
L	LEU230
L	ILE360
L	HIS364
L	GLY388
L	ALA389
L	ARG392

site_id	AC6
Number of Residues	6
Details	binding site for residue ADP M 501

Chain	Residue
M	PRO224
M	GLY225
M	THR226
M	GLY227
M	LYS228
M	ILE360

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdgdtVtFSPtGRlfQVEYAleA

Chain	Residue	Details
F	TYR6-ALA28
B	TYR5-ALA27
G	TYR8-ALA30

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVLaATNrvdvLDpALl.R

Chain	Residue	Details
M	VAL321-ARG339
H	ILE349-ARG367
I	VAL322-ARG340
J	ILE288-ARG306
L	THR321-ARG339
K	VAL312-ARG330

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. IGImAsdGIVLAAErkvtstlleqdtste.KlyklndkiavavaGltAD

Chain	Residue	Details
C	ILE36-ASP83
D	VAL34-ASP81

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
M	GLY222
C	LYS199
C	LYS231

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
M	TYR180
I	LYS255
I	LYS290

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)