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6EF1

Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000502cellular_componentproteasome complex
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0010499biological_processproteasomal ubiquitin-independent protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
B0000502cellular_componentproteasome complex
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0010499biological_processproteasomal ubiquitin-independent protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0034515cellular_componentproteasome storage granule
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051603biological_processproteolysis involved in protein catabolic process
C0000502cellular_componentproteasome complex
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0010499biological_processproteasomal ubiquitin-independent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0034515cellular_componentproteasome storage granule
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
C0080129biological_processproteasome core complex assembly
D0000502cellular_componentproteasome complex
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0010499biological_processproteasomal ubiquitin-independent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0034515cellular_componentproteasome storage granule
D0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0010499biological_processproteasomal ubiquitin-independent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0034515cellular_componentproteasome storage granule
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0003674molecular_functionmolecular_function
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0010499biological_processproteasomal ubiquitin-independent protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0034515cellular_componentproteasome storage granule
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0051603biological_processproteolysis involved in protein catabolic process
G0005839cellular_componentproteasome core complex
G0006511biological_processubiquitin-dependent protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0051603biological_processproteolysis involved in protein catabolic process
H0005524molecular_functionATP binding
H0016887molecular_functionATP hydrolysis activity
I0005524molecular_functionATP binding
I0016887molecular_functionATP hydrolysis activity
J0005524molecular_functionATP binding
J0016887molecular_functionATP hydrolysis activity
K0005524molecular_functionATP binding
K0016887molecular_functionATP hydrolysis activity
L0005524molecular_functionATP binding
L0016887molecular_functionATP hydrolysis activity
M0005524molecular_functionATP binding
M0016887molecular_functionATP hydrolysis activity
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue ATP H 501
ChainResidue
HVAL211
HGLY416
HALA417
HARG420
ILEU310
IASP314
IARG340
HGLY213
HPRO252
HGLY253
HTHR254
HGLY255
HLYS256
HTHR257
HILE388

site_idAC2
Number of Residues12
Detailsbinding site for residue ATP I 501
ChainResidue
IILE184
ITHR227
IGLY228
ILYS229
ITHR230
ILEU231
IILE361
IALA390
IGLN393
JLEU273
JASN277
JARG309

site_idAC3
Number of Residues12
Detailsbinding site for residue ATP J 501
ChainResidue
JMET149
JVAL150
JGLY151
JPRO191
JGLY192
JTHR193
JGLY194
JLYS195
JTHR196
JGLY355
JALA356
KARG330

site_idAC4
Number of Residues13
Detailsbinding site for residue ATP K 501
ChainResidue
KASP173
KVAL174
KPRO214
KPRO215
KGLY216
KTHR217
KGLY218
KLYS219
KTHR220
KMET221
KILE352
KGLY380
KALA381

site_idAC5
Number of Residues12
Detailsbinding site for residue ADP L 501
ChainResidue
LILE183
LGLY225
LTHR226
LGLY227
LLYS228
LTHR229
LLEU230
LILE360
LHIS364
LGLY388
LALA389
LARG392

site_idAC6
Number of Residues6
Detailsbinding site for residue ADP M 501
ChainResidue
MPRO224
MGLY225
MTHR226
MGLY227
MLYS228
MILE360

Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdgdtVtFSPtGRlfQVEYAleA
ChainResidueDetails
FTYR6-ALA28
BTYR5-ALA27
GTYR8-ALA30

site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. VkVLaATNrvdvLDpALl.R
ChainResidueDetails
MVAL321-ARG339
HILE349-ARG367
IVAL322-ARG340
JILE288-ARG306
LTHR321-ARG339
KVAL312-ARG330

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. IGImAsdGIVLAAErkvtstlleqdtste.KlyklndkiavavaGltAD
ChainResidueDetails
CILE36-ASP83
DVAL34-ASP81

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
MGLY222
CLYS199
CLYS231

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19779198
ChainResidueDetails
MTYR180
ILYS255
ILYS290

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PDB entries from 2024-09-18

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