6EDW

Crystal structure of Mycobacterium tuberculosis ICL2 in the apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004451	molecular_function	isocitrate lyase activity
A	0006097	biological_process	glyoxylate cycle
A	0006099	biological_process	tricarboxylic acid cycle
A	0016829	molecular_function	lyase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004451	molecular_function	isocitrate lyase activity
B	0006097	biological_process	glyoxylate cycle
B	0006099	biological_process	tricarboxylic acid cycle
B	0016829	molecular_function	lyase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004451	molecular_function	isocitrate lyase activity
C	0006097	biological_process	glyoxylate cycle
C	0006099	biological_process	tricarboxylic acid cycle
C	0016829	molecular_function	lyase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004451	molecular_function	isocitrate lyase activity
D	0006097	biological_process	glyoxylate cycle
D	0006099	biological_process	tricarboxylic acid cycle
D	0016829	molecular_function	lyase activity
D	0019752	biological_process	carboxylic acid metabolic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 801

Chain	Residue
A	ASP17
A	PHE18
A	THR52
A	HOH1026
A	HOH1041
A	HOH1199
B	HIS151

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 802

Chain	Residue
B	GLY51
B	THR52
B	HOH1067
B	HOH1098
B	HOH1140
A	HIS151
B	PHE18

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 803

Chain	Residue
A	ALA450
A	ALA453
A	GLN482
A	HOH1452
A	HOH1477

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 804

Chain	Residue
A	ASP123
A	ASP177
A	ASP179
A	LYS213
A	HOH945
A	HOH984

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG B 801

Chain	Residue
B	ALA450
B	ALA453
B	GLN482
B	HOH1560
B	HOH1595

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL C 801

Chain	Residue
C	ARG78
C	ALA472
C	HIS476
C	LYS513
C	MET514
C	HOH1107

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL C 802

Chain	Residue
C	HIS151
C	HOH983
C	HOH1028
C	HOH1092
C	HOH1144
D	PHE18
D	THR52
D	HOH937

---

site_id	AC8
Number of Residues	5
Details	binding site for residue MG C 803

Chain	Residue
C	ALA450
C	ALA453
C	GLN482
C	HOH1454
C	HOH1460

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MG C 804

Chain	Residue
C	ASP177
C	ASP179
C	LYS213
C	HOH920
C	HOH1217

---

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL D 801

Chain	Residue
C	ASP17
C	PHE18
C	THR52
C	HOH955
D	HIS151
D	HOH1081
D	HOH1090
D	HOH1151

---

site_id	AD2
Number of Residues	5
Details	binding site for residue MG D 802

Chain	Residue
D	ALA450
D	ALA453
D	GLN482
D	HOH1510
D	HOH1524

---

site_id	AD3
Number of Residues	6
Details	binding site for residue MG D 803

Chain	Residue
D	ASP123
D	ASP177
D	ASP179
D	LYS213
D	HOH922
D	HOH934

---

Functional Information from PROSITE/UniProt

site_id	PS00161
Number of Residues	6
Details	ISOCITRATE_LYASE Isocitrate lyase signature. KKCGHQ

Chain	Residue	Details
A	LYS213-GLN218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P9WKK7

Chain	Residue	Details
A	CSX215
B	CSX215
C	CSX215
D	CSX215

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P9WKK7

Chain	Residue	Details
A	GLY106
B	ARG252
B	ASN487
B	THR522
C	GLY106
C	ASP177
C	GLY216
C	ARG252
C	ASN487
C	THR522
D	GLY106
A	ASP177
D	ASP177
D	GLY216
D	ARG252
D	ASN487
D	THR522
A	GLY216
A	ARG252
A	ASN487
A	THR522
B	GLY106
B	ASP177
B	GLY216

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