6E8E
Crystal structure of the Escherichia coli sliding clamp-MutL complex.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0006298 | biological_process | mismatch repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| A | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044787 | biological_process | bacterial-type DNA replication |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006260 | biological_process | DNA replication |
| B | 0006261 | biological_process | DNA-templated DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0006298 | biological_process | mismatch repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| B | 0032297 | biological_process | negative regulation of DNA-templated DNA replication initiation |
| B | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044787 | biological_process | bacterial-type DNA replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 601 |
| Chain | Residue |
| A | ARG206 |
| A | SER219 |
| A | TYR282 |
| A | GLN393 |
| A | SER394 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | GLN187 |
| A | ASN194 |
| A | ARG235 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| B | TRP160 |
| B | GLN161 |
| B | SER258 |
| B | ASN259 |
| B | ASN260 |
| A | TYR191 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | ARG190 |
| A | GLY212 |
| A | ILE434 |
| A | HOH711 |
| A | HOH773 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | GLN224 |
| A | SER225 |
| A | HOH727 |
| B | GLY140 |
| B | ARG141 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | HIS213 |
| A | ASN358 |
| A | TYR361 |
| A | MET402 |
| A | LEU476 |
| A | ARG479 |
| A | GLN480 |
| A | HOH708 |
| A | HOH732 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 607 |
| Chain | Residue |
| A | PRO287 |
| A | LYS288 |
| A | SER384 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 601 |
| Chain | Residue |
| B | GLN187 |
| B | ASN194 |
| B | ARG235 |
| B | HOH749 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | ARG190 |
| B | GLY212 |
| B | ILE434 |
| B | LEU436 |
| B | HOH754 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | ASN358 |
| B | TYR361 |
| B | LEU476 |
| B | ARG479 |
| B | GLN480 |
| B | HOH706 |
| B | HOH759 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | PRO477 |
| B | HOH719 |
| B | HOH762 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 228 |
| Details | Region: {"description":"2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | Region: {"description":"3","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18191219","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
