6E8E

Crystal structure of the Escherichia coli sliding clamp-MutL complex.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0006298	biological_process	mismatch repair
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009360	cellular_component	DNA polymerase III complex
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030894	cellular_component	replisome
A	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
A	0042276	biological_process	error-prone translesion synthesis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044787	biological_process	bacterial-type DNA replication
A	1990078	cellular_component	replication inhibiting complex
A	1990085	cellular_component	Hda-beta clamp complex
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006298	biological_process	mismatch repair
B	0006974	biological_process	DNA damage response
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009360	cellular_component	DNA polymerase III complex
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0030894	cellular_component	replisome
B	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
B	0042276	biological_process	error-prone translesion synthesis
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044787	biological_process	bacterial-type DNA replication
B	1990078	cellular_component	replication inhibiting complex
B	1990085	cellular_component	Hda-beta clamp complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 601

Chain	Residue
A	ARG206
A	SER219
A	TYR282
A	GLN393
A	SER394

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 602

Chain	Residue
A	GLN187
A	ASN194
A	ARG235

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 603

Chain	Residue
B	TRP160
B	GLN161
B	SER258
B	ASN259
B	ASN260
A	TYR191

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL A 604

Chain	Residue
A	ARG190
A	GLY212
A	ILE434
A	HOH711
A	HOH773

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 605

Chain	Residue
A	GLN224
A	SER225
A	HOH727
B	GLY140
B	ARG141

---

site_id	AC6
Number of Residues	9
Details	binding site for residue SO4 A 606

Chain	Residue
A	HIS213
A	ASN358
A	TYR361
A	MET402
A	LEU476
A	ARG479
A	GLN480
A	HOH708
A	HOH732

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 607

Chain	Residue
A	PRO287
A	LYS288
A	SER384

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL B 601

Chain	Residue
B	GLN187
B	ASN194
B	ARG235
B	HOH749

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL B 602

Chain	Residue
B	ARG190
B	GLY212
B	ILE434
B	LEU436
B	HOH754

---

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 B 603

Chain	Residue
B	ASN358
B	TYR361
B	LEU476
B	ARG479
B	GLN480
B	HOH706
B	HOH759

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 604

Chain	Residue
B	PRO477
B	HOH719
B	HOH762

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:18191219

Chain	Residue	Details
B	ARG62
B	GLN187
B	TYR191

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18191219

Chain	Residue	Details
B	ARG111

---