6E7M

Crystal structure of the holo retinal-bound domain-swapped dimer Q108K:T51D:A28C mutant of human Cellular Retinol Binding Protein II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0005501	molecular_function	retinoid binding
A	0005504	molecular_function	fatty acid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006776	biological_process	vitamin A metabolic process
A	0008289	molecular_function	lipid binding
A	0008544	biological_process	epidermis development
A	0015908	biological_process	fatty acid transport
A	0016918	molecular_function	retinal binding
A	0019432	biological_process	triglyceride biosynthetic process
A	0019841	molecular_function	retinol binding
A	0140104	molecular_function	molecular carrier activity
B	0001523	biological_process	retinoid metabolic process
B	0005501	molecular_function	retinoid binding
B	0005504	molecular_function	fatty acid binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006776	biological_process	vitamin A metabolic process
B	0008289	molecular_function	lipid binding
B	0008544	biological_process	epidermis development
B	0015908	biological_process	fatty acid transport
B	0016918	molecular_function	retinal binding
B	0019432	biological_process	triglyceride biosynthetic process
B	0019841	molecular_function	retinol binding
B	0140104	molecular_function	molecular carrier activity
C	0001523	biological_process	retinoid metabolic process
C	0005501	molecular_function	retinoid binding
C	0005504	molecular_function	fatty acid binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006776	biological_process	vitamin A metabolic process
C	0008289	molecular_function	lipid binding
C	0008544	biological_process	epidermis development
C	0015908	biological_process	fatty acid transport
C	0016918	molecular_function	retinal binding
C	0019432	biological_process	triglyceride biosynthetic process
C	0019841	molecular_function	retinol binding
C	0140104	molecular_function	molecular carrier activity
D	0001523	biological_process	retinoid metabolic process
D	0005501	molecular_function	retinoid binding
D	0005504	molecular_function	fatty acid binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006776	biological_process	vitamin A metabolic process
D	0008289	molecular_function	lipid binding
D	0008544	biological_process	epidermis development
D	0015908	biological_process	fatty acid transport
D	0016918	molecular_function	retinal binding
D	0019432	biological_process	triglyceride biosynthetic process
D	0019841	molecular_function	retinol binding
D	0140104	molecular_function	molecular carrier activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ACT A 201

Chain	Residue
A	HIS81
A	GLU100
D	TRP109
D	TYR116
D	LEU117
D	GLU118

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 202

Chain	Residue
D	ARG80
A	ARG35
A	THR37
D	ASN79

---

site_id	AC3
Number of Residues	6
Details	binding site for residue ACT A 203

Chain	Residue
A	LYS40
A	ASP51
C	TRP106
C	LYS108
C	LEU117
C	LEU119

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 204

Chain	Residue
A	GLY6
A	THR7
A	LYS21
A	ILE25
A	ARG30
A	VAL41
A	ASP43
A	HOH301

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 205

Chain	Residue
A	GLN38
A	THR53
A	HOH305
C	TYR60
C	GLN128

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL A 206

Chain	Residue
A	ASN48
A	PHE49
A	LYS50
B	ARG127
C	ASP63
C	PHE64
C	THR65

---

site_id	AC7
Number of Residues	1
Details	binding site for residue ACT B 201

Chain	Residue
B	VAL92

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL B 202

Chain	Residue
A	VAL125
A	ARG127
B	HIS81
B	GLU100
C	GLU14

---

site_id	AC9
Number of Residues	3
Details	binding site for residue ACT C 201

Chain	Residue
A	LYS114
A	TYR116
C	GLU11

---

site_id	AD1
Number of Residues	3
Details	binding site for residue ACT C 202

Chain	Residue
A	ASP47
C	ARG30
C	TRP88

---

site_id	AD2
Number of Residues	5
Details	binding site for residue ACT C 203

Chain	Residue
A	LEU23
A	ASP24
C	ASP78
C	ARG80
C	LYS133

---

site_id	AD3
Number of Residues	1
Details	binding site for residue ACT C 204

Chain	Residue
C	PHE16

---

site_id	AD4
Number of Residues	5
Details	binding site for residue ACT C 205

Chain	Residue
A	TYR19
C	TYR60
C	GLN97
C	ARG104
C	LEU119

---

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL C 206

Chain	Residue
C	ASN5
C	GLY6
C	VAL41
C	ILE42
C	ASN103
C	GLY122

---

site_id	AD6
Number of Residues	6
Details	binding site for residue ACT D 201

Chain	Residue
D	TYR60
D	VAL62
D	GLU72
D	CYS95
D	GLN97
D	TRP106

---

site_id	AD7
Number of Residues	8
Details	binding site for residue GOL D 202

Chain	Residue
D	VAL94
D	CYS95
D	VAL96
D	ASN103
D	GLY105
D	TRP106
D	LYS107
D	THR120

---

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWeMesNeNFEgYMKAL

Chain	Residue	Details
A	GLY6-LEU23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18076076","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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